Q9ZRR8 (CHS1_CASGL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chalcone synthase
EC=2.3.1.74

Alternative name(s):
Naringenin-chalcone synthase

Gene names

Name:

CHS1

Organism

Casuarina glauca (Swamp oak)

Taxonomic identifier

3522 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fagales › Casuarinaceae › Casuarina

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
Catalytic activity	3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.
Pathway	Secondary metabolite biosynthesis; flavonoid biosynthesis.
Sequence similarities	Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
Biological process	Flavonoid biosynthesis
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological_process	flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	naringenin-chalcone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Chalcone synthase		PRO_0000215964
Sites
	Active site	164	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZRR8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 185BE6F345EFA7DD	FASTA	389	42,603
	10 20 30 40 50 60 MVTVEEVRKA QRAEGPATVL AIGTATPPNC LDQSTYPDYY FRITNSEHKT ELKEKFQRMC 70 80 90 100 110 120 DKSMIKKRYM YLTEEILKEH PNMCAYMAPS LDARQDMVVV EIPKLGKEAA VKAIKEWGQP 130 140 150 160 170 180 KSKITHLVFC TTSGVDMPGA DYQLTKLLGL RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN 190 200 210 220 230 240 NRGARVLVVC SEITAVTFRG PSDTHLDSLV GQALFGDGAA AIIVGADPLP EVEKPLFEVV 250 260 270 280 290 300 STAQTILPDS DGAIDGHLRE VGVTFHLLKD VPGLISKNIE KSLVEAFQPL GISDWNSLFW 310 320 330 340 350 360 IAHPGGPAIL DQVEEKLALK PEKLGATRHV LSEYGNMSSA CVLFILDEMR RKSAEKGLKT 370 380 TGEGLDWGVL FGFGPGLTVE TVVLHSLTT

References

[1]

"Flavan-containing cells delimit Frankia infected compartments in Casuarina glauca nodules." Laplaze L., Gherbi H., Frutz T., Pawlowski K., Franche C., Macheix J.J., Auguy F., Bogusz D., Duhoux E. Plant Physiol. 121:113-122(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Root nodule.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ132323 mRNA. Translation: CAA10641.1.
3D structure databases
ProteinModelPortal	Q9ZRR8.
SMR	Q9ZRR8. Positions 3-387.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00154.
Family and domain databases
Gene3D	3.40.47.10. 2 hits.
InterPro	IPR012328. Chalcone/stilbene_synth_C. IPR018088. Chalcone/stilbene_synthase_AS. IPR001099. Chalcone/stilbene_synthase_N. IPR011141. Polyketide_synthase_type-III. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF02797. Chal_sti_synt_C. 1 hit. PF00195. Chal_sti_synt_N. 1 hit. [Graphical view]
PIRSF	PIRSF000451. PKS_III. 1 hit.
SUPFAM	SSF53901. Thiolase-like. 2 hits.
PROSITE	PS00441. CHALCONE_SYNTH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHS1_CASGL

Accession

Primary (citable) accession number: Q9ZRR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program