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Protein

L-lactate dehydrogenase

Gene

Os02g0105400

Organism
Oryza sativa subsp. japonica (Rice)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Os06g0104900), L-lactate dehydrogenase (OsJ_19824), L-lactate dehydrogenase (Os02g0105400), L-lactate dehydrogenase (Os02g0105400)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Active sitei212Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-OSA-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Os02g0105400Imported
Synonyms:OJA1212_C06.25Imported
ORF Names:OJ1212_C06.24Imported, OJ1359_D06.5Imported, OsJ_05023Imported, OSNPB_020105400Imported
OrganismiOryza sativa subsp. japonica (Rice)Imported
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 179Ldh_1_NInterPro annotationAdd BLAST140
Domaini182 – 348Ldh_1_CInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZRJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKASSLSEL GFDAEGASSG FFRPVADGGS TPTSHRRRLT KISVIGAGNV
60 70 80 90 100
GMAIAQTILT RDMADEIALV DAVPDKLRGE MLDLQHAAAF LPRVRLVSDT
110 120 130 140 150
DLAVTRGSDL AIVTAGARQI PGESRLNLLQ RNVALFRKIV PALAEHSPEA
160 170 180 190 200
LLLIVSNPVD VLTYVAWKLS GFPASRVIGS GTNLDSSRFR FLLAEHLQVN
210 220 230 240 250
AQDVQAYMVG EHGDSSVAIW SSMSVAGMPV LKSLRESHQS FDEEALEGIR
260 270 280 290 300
RAVVDSAYEV ISLKGYTSWA IGYSVASLAA SLLRDQHRIH PVSVLASGFH
310 320 330 340 350
GIPQDHEVFL SLPARLGRAG VLGVAEMELT EEEARRLRRS AKTLWENCQL

LDL
Length:353
Mass (Da):38,171
Last modified:May 1, 1999 - v1
Checksum:iFD670CDA2AF28D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13817 mRNA. Translation: BAA02971.1.
AP006720 Genomic DNA. Translation: BAD06283.1.
AP004049 Genomic DNA. Translation: BAD07543.1.
AP004851 Genomic DNA. Translation: BAD28080.1.
AP014958 Genomic DNA. Translation: BAS76559.1.
CM000139 Genomic DNA. Translation: EAZ21418.1.
PIRiT03785.
UniGeneiOs.10215.
Os.88367.

Genome annotation databases

EnsemblPlantsiOS02T0105400-02; OS02T0105400-02; OS02G0105400.
GrameneiOS02T0105400-02; OS02T0105400-02; OS02G0105400.

Similar proteinsi

Entry informationi

Entry nameiQ9ZRJ5_ORYSJ
AccessioniPrimary (citable) accession number: Q9ZRJ5
Secondary accession number(s): Q43000
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported