Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9ZRI8

- FDH_HORVU

UniProt

Q9ZRI8 - FDH_HORVU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate dehydrogenase, mitochondrial

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541NAD; via carbonyl oxygenBy similarity
Active sitei283 – 2831By similarity
Binding sitei307 – 3071NADBy similarity
Active sitei331 – 3311Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2012NADBy similarity
Nucleotide bindingi281 – 2833NADBy similarity
Nucleotide bindingi331 – 3344NADBy similarity

GO - Molecular functioni

  1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  2. NAD binding Source: EnsemblPlants/Gramene
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase, mitochondrial (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name:
FDH
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiQ9ZRI8.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. chloroplast Source: EnsemblPlants/Gramene
  2. mitochondrion Source: UniProtKB-KW
  3. thylakoid Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionBy similarityAdd
BLAST
Chaini22 – 377356Formate dehydrogenase, mitochondrialPRO_0000007194Add
BLAST

Proteomic databases

PRIDEiQ9ZRI8.

Expressioni

Gene expression databases

GenevestigatoriQ9ZRI8.

Interactioni

Protein-protein interaction databases

IntActiQ9ZRI8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRI8.
SMRiQ9ZRI8. Positions 43-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZRI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAMWRAAAR QLVDRAVGSR AAHTSAGSKK IVGVFYQAGE YADKNPNFVG
60 70 80 90 100
CVEGALGIRD WLESKGHHYI VTDDKEGFNS ELEKHIEDMH VLITTPFHPA
110 120 130 140 150
YVTAEKIKKA KTPELLLTAG IGSDHIDLPA AAAAGLTVAR VTGSNTVSVA
160 170 180 190 200
EDELMRILIL LRNFLPGYQQ VVKGEWNVAG IAHRAYDLEG KTVGTVGAGR
210 220 230 240 250
YGRLLLQRLK PFNCNLLYHD RLQINPELEK EIGAKFEEDL DAMLPKCDVV
260 270 280 290 300
VINTPLTEKT RGMFNKEKIA KMKKGVIIVN NARGAIMDTQ AVADACSSGH
310 320 330 340 350
IAGYGGDVWF PQPAPKDHPW RYMPNHAMTP HISGTTIDAQ LRYAAGVKDM
360 370
LDRYFKGEEF PVENYIVKEG ELASQYK
Length:377
Mass (Da):41,546
Last modified:May 1, 1999 - v1
Checksum:iE28C1FE24E9225C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88272 mRNA. Translation: BAA36181.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88272 mRNA. Translation: BAA36181.1 .

3D structure databases

ProteinModelPortali Q9ZRI8.
SMRi Q9ZRI8. Positions 43-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ZRI8. 1 interaction.

Proteomic databases

PRIDEi Q9ZRI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q9ZRI8.

Gene expression databases

Genevestigatori Q9ZRI8.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Formate dehydrogenase, an enzyme of anaerobic metabolism, is induced by iron deficiency in barley roots."
    Suzuki K., Itai R., Suzuki K., Nakanishi H., Nishizawa N.K., Yoshimura E., Mori S.
    Plant Physiol. 116:725-732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Ehimehadaka No.1.
    Tissue: Root.

Entry informationi

Entry nameiFDH_HORVU
AccessioniPrimary (citable) accession number: Q9ZRI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3