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Protein

Formate dehydrogenase, mitochondrial

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.UniRule annotation

Catalytic activityi

Formate + NAD+ = CO2 + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Substrate; via amide nitrogenUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Binding sitei146NADUniRule annotation1
Binding sitei220NADUniRule annotation1
Binding sitei281NAD; via carbonyl oxygenUniRule annotation1
Sitei283Important for catalytic activityUniRule annotation1
Binding sitei307NADUniRule annotation1
Sitei331Important for catalytic activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi255 – 259NADUniRule annotation5
Nucleotide bindingi331 – 334NADUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase, mitochondrial1 PublicationUniRule annotation (EC:1.17.1.9UniRule annotation)
Short name:
FDHUniRule annotation
Alternative name(s):
NAD-dependent formate dehydrogenaseUniRule annotation
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionUniRule annotationAdd BLAST29
ChainiPRO_000000719430 – 377Formate dehydrogenase, mitochondrialAdd BLAST348

Proteomic databases

PRIDEiQ9ZRI8

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZRI8 baseline and differential

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ9ZRI8, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9ZRI8
SMRiQ9ZRI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 145CatalyticUniRule annotationAdd BLAST116
Regioni146 – 332Coenzyme-bindingUniRule annotationAdd BLAST187
Regioni333 – 376CatalyticUniRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0069 Eukaryota
COG1052 LUCA

Family and domain databases

CDDicd05302 FDH, 1 hit
HAMAPiMF_03210 Formate_dehydrogenase, 1 hit
InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR033689 FDH_NAD-dep
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZRI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMWRAAAR QLVDRAVGSR AAHTSAGSKK IVGVFYQAGE YADKNPNFVG
60 70 80 90 100
CVEGALGIRD WLESKGHHYI VTDDKEGFNS ELEKHIEDMH VLITTPFHPA
110 120 130 140 150
YVTAEKIKKA KTPELLLTAG IGSDHIDLPA AAAAGLTVAR VTGSNTVSVA
160 170 180 190 200
EDELMRILIL LRNFLPGYQQ VVKGEWNVAG IAHRAYDLEG KTVGTVGAGR
210 220 230 240 250
YGRLLLQRLK PFNCNLLYHD RLQINPELEK EIGAKFEEDL DAMLPKCDVV
260 270 280 290 300
VINTPLTEKT RGMFNKEKIA KMKKGVIIVN NARGAIMDTQ AVADACSSGH
310 320 330 340 350
IAGYGGDVWF PQPAPKDHPW RYMPNHAMTP HISGTTIDAQ LRYAAGVKDM
360 370
LDRYFKGEEF PVENYIVKEG ELASQYK
Length:377
Mass (Da):41,546
Last modified:May 1, 1999 - v1
Checksum:iE28C1FE24E9225C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88272 mRNA Translation: BAA36181.1

Similar proteinsi

Entry informationi

Entry nameiFDH_HORVU
AccessioniPrimary (citable) accession number: Q9ZRI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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