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Q9ZRI8

- FDH_HORVU

UniProt

Q9ZRI8 - FDH_HORVU

Protein

Formate dehydrogenase, mitochondrial

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei254 – 2541NAD; via carbonyl oxygenBy similarity
    Active sitei283 – 2831By similarity
    Binding sitei307 – 3071NADBy similarity
    Active sitei331 – 3311Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi200 – 2012NADBy similarity
    Nucleotide bindingi281 – 2833NADBy similarity
    Nucleotide bindingi331 – 3344NADBy similarity

    GO - Molecular functioni

    1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. response to cadmium ion Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase, mitochondrial (EC:1.2.1.2)
    Alternative name(s):
    NAD-dependent formate dehydrogenase
    Short name:
    FDH
    OrganismiHordeum vulgare (Barley)
    Taxonomic identifieri4513 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

    Organism-specific databases

    GrameneiQ9ZRI8.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. chloroplast Source: EnsemblPlants/Gramene
    2. mitochondrion Source: UniProtKB-SubCell
    3. thylakoid Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionBy similarityAdd
    BLAST
    Chaini22 – 377356Formate dehydrogenase, mitochondrialPRO_0000007194Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZRI8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZRI8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9ZRI8. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZRI8.
    SMRiQ9ZRI8. Positions 43-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZRI8-1 [UniParc]FASTAAdd to Basket

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    MAAMWRAAAR QLVDRAVGSR AAHTSAGSKK IVGVFYQAGE YADKNPNFVG    50
    CVEGALGIRD WLESKGHHYI VTDDKEGFNS ELEKHIEDMH VLITTPFHPA 100
    YVTAEKIKKA KTPELLLTAG IGSDHIDLPA AAAAGLTVAR VTGSNTVSVA 150
    EDELMRILIL LRNFLPGYQQ VVKGEWNVAG IAHRAYDLEG KTVGTVGAGR 200
    YGRLLLQRLK PFNCNLLYHD RLQINPELEK EIGAKFEEDL DAMLPKCDVV 250
    VINTPLTEKT RGMFNKEKIA KMKKGVIIVN NARGAIMDTQ AVADACSSGH 300
    IAGYGGDVWF PQPAPKDHPW RYMPNHAMTP HISGTTIDAQ LRYAAGVKDM 350
    LDRYFKGEEF PVENYIVKEG ELASQYK 377
    Length:377
    Mass (Da):41,546
    Last modified:May 1, 1999 - v1
    Checksum:iE28C1FE24E9225C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88272 mRNA. Translation: BAA36181.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88272 mRNA. Translation: BAA36181.1 .

    3D structure databases

    ProteinModelPortali Q9ZRI8.
    SMRi Q9ZRI8. Positions 43-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ZRI8. 1 interaction.

    Proteomic databases

    PRIDEi Q9ZRI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q9ZRI8.

    Gene expression databases

    Genevestigatori Q9ZRI8.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Formate dehydrogenase, an enzyme of anaerobic metabolism, is induced by iron deficiency in barley roots."
      Suzuki K., Itai R., Suzuki K., Nakanishi H., Nishizawa N.K., Yoshimura E., Mori S.
      Plant Physiol. 116:725-732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Ehimehadaka No.1.
      Tissue: Root.

    Entry informationi

    Entry nameiFDH_HORVU
    AccessioniPrimary (citable) accession number: Q9ZRI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3