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Q9ZRI8

- FDH_HORVU

UniProt

Q9ZRI8 - FDH_HORVU

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Protein
Formate dehydrogenase, mitochondrial
Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541NAD; via carbonyl oxygen By similarity
Active sitei283 – 2831 By similarity
Binding sitei307 – 3071NAD By similarity
Active sitei331 – 3311Proton donor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2012NAD By similarity
Nucleotide bindingi281 – 2833NAD By similarity
Nucleotide bindingi331 – 3344NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. response to cadmium ion Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase, mitochondrial (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name:
FDH
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiQ9ZRI8.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. chloroplast Source: EnsemblPlants/Gramene
  2. mitochondrion Source: UniProtKB-SubCell
  3. thylakoid Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion By similarity
Add
BLAST
Chaini22 – 377356Formate dehydrogenase, mitochondrial
PRO_0000007194Add
BLAST

Proteomic databases

PRIDEiQ9ZRI8.

Expressioni

Gene expression databases

GenevestigatoriQ9ZRI8.

Interactioni

Protein-protein interaction databases

IntActiQ9ZRI8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRI8.
SMRiQ9ZRI8. Positions 43-373.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZRI8-1 [UniParc]FASTAAdd to Basket

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MAAMWRAAAR QLVDRAVGSR AAHTSAGSKK IVGVFYQAGE YADKNPNFVG    50
CVEGALGIRD WLESKGHHYI VTDDKEGFNS ELEKHIEDMH VLITTPFHPA 100
YVTAEKIKKA KTPELLLTAG IGSDHIDLPA AAAAGLTVAR VTGSNTVSVA 150
EDELMRILIL LRNFLPGYQQ VVKGEWNVAG IAHRAYDLEG KTVGTVGAGR 200
YGRLLLQRLK PFNCNLLYHD RLQINPELEK EIGAKFEEDL DAMLPKCDVV 250
VINTPLTEKT RGMFNKEKIA KMKKGVIIVN NARGAIMDTQ AVADACSSGH 300
IAGYGGDVWF PQPAPKDHPW RYMPNHAMTP HISGTTIDAQ LRYAAGVKDM 350
LDRYFKGEEF PVENYIVKEG ELASQYK 377
Length:377
Mass (Da):41,546
Last modified:May 1, 1999 - v1
Checksum:iE28C1FE24E9225C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88272 mRNA. Translation: BAA36181.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88272 mRNA. Translation: BAA36181.1 .

3D structure databases

ProteinModelPortali Q9ZRI8.
SMRi Q9ZRI8. Positions 43-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ZRI8. 1 interaction.

Proteomic databases

PRIDEi Q9ZRI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q9ZRI8.

Gene expression databases

Genevestigatori Q9ZRI8.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Formate dehydrogenase, an enzyme of anaerobic metabolism, is induced by iron deficiency in barley roots."
    Suzuki K., Itai R., Suzuki K., Nakanishi H., Nishizawa N.K., Yoshimura E., Mori S.
    Plant Physiol. 116:725-732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Ehimehadaka No.1.
    Tissue: Root.

Entry informationi

Entry nameiFDH_HORVU
AccessioniPrimary (citable) accession number: Q9ZRI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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