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Q9ZRA2 (HGD_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:HGO
Ordered Locus Names:At5g54080
ORF Names:MJP23.6
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactor

Iron.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Homogentisate 1,2-dioxygenase
PRO_0000220244

Sites

Metal binding3411Iron By similarity
Metal binding3471Iron By similarity
Metal binding3771Iron By similarity

Experimental info

Sequence conflict71E → K in AAM65958. Ref.6
Sequence conflict691V → I in AAM65958. Ref.6
Sequence conflict1161I → T in AAM65958. Ref.6
Sequence conflict1461T → K in AAM65958. Ref.6
Sequence conflict1811T → S in AAM65958. Ref.6
Sequence conflict2311S → P in AAM65958. Ref.6
Sequence conflict4281D → E in AAD00360. Ref.1
Sequence conflict4521S → P in AAM65958. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9ZRA2 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: CD90DD9638014D31

FASTA46151,455
        10         20         30         40         50         60 
MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS GTSFTSPRKL 

        70         80         90        100        110        120 
NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN PTQLRWRPED IPDSEIDFVD 

       130        140        150        160        170        180 
GLFTICGAGS SFLRHGFAIH MYVANTGMKD SAFCNADGDF LLVPQTGRLW IETECGRLLV 

       190        200        210        220        230        240 
TPGEIAVIPQ GFRFSIDLPD GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW 

       250        260        270        280        290        300 
FEDGLRPEYT IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD 

       310        320        330        340        350        360 
PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG LIYGAYEAKA 

       370        380        390        400        410        420 
DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT GTMAFMFESA LIPRVCHWAL 

       430        440        450        460 
ESPFLDHDYY QCWIGLKSHF SRISLDKTNV ESTEKEPGAS E 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
Schmidt S.R., Werner E., Mueller C.R., Kress W.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Columbia.
[2]Schmidt S.R.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[4]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U80668 mRNA. Translation: AAD00360.1.
AF130845 Genomic DNA. Translation: AAF36499.1.
AB018115 Genomic DNA. Translation: BAA97130.1.
CP002688 Genomic DNA. Translation: AED96447.1.
CP002688 Genomic DNA. Translation: AED96448.1.
AY140075 mRNA. Translation: AAM98216.1.
BT010329 mRNA. Translation: AAQ55280.1.
AY088421 mRNA. Translation: AAM65958.1.
RefSeqNP_200219.1. NM_124787.3.
NP_851187.1. NM_180856.3.
UniGeneAt.23160.
At.72265.

3D structure databases

ProteinModelPortalQ9ZRA2.
SMRQ9ZRA2. Positions 10-441.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9ZRA2.
PRIDEQ9ZRA2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G54080.1; AT5G54080.1; AT5G54080.
AT5G54080.2; AT5G54080.2; AT5G54080.
GeneID835494.
KEGGath:AT5G54080.

Organism-specific databases

TAIRAT5G54080.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
InParanoidQ9ZRA2.
KOK00451.
OMACWEPLKS.
PhylomeDBQ9ZRA2.
ProtClustDBPLN02658.

Enzyme and pathway databases

BioCycARA:AT5G54080-MONOMER.
ARA:GQT-2804-MONOMER.
BRENDA1.13.11.5. 399.
UniPathwayUPA00139; UER00339.

Gene expression databases

GenevestigatorQ9ZRA2.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Other

PROQ9ZRA2.

Entry information

Entry nameHGD_ARATH
AccessionPrimary (citable) accession number: Q9ZRA2
Secondary accession number(s): Q8L9I0, Q9LDB8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: February 19, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names