Reviewed,
UniProtKB/Swiss-Prot Q9ZRA2 (HGD_ARATH)
Last modified
November 4, 2008.
Version 59.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisic acid oxidase Homogentisate oxygenase Homogentisicase | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 461 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Homogentisate + O(2) = 4-maleylacetoacetate. |
| Cofactor | Iron. |
| Pathway | |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 461 | 461 | Homogentisate 1,2-dioxygenase | PRO_0000220244 | |||||
Sites | |||||||||
| Metal binding | 341 | 1 | Iron By similarity | ||||||
| Metal binding | 347 | 1 | Iron By similarity | ||||||
| Metal binding | 377 | 1 | Iron By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 7 | 1 | E → K in AAM65958. Ref.5 | ||||||
| Sequence conflict | 69 | 1 | V → I in AAM65958. Ref.5 | ||||||
| Sequence conflict | 116 | 1 | I → T in AAM65958. Ref.5 | ||||||
| Sequence conflict | 146 | 1 | T → K in AAM65958. Ref.5 | ||||||
| Sequence conflict | 181 | 1 | T → S in AAM65958. Ref.5 | ||||||
| Sequence conflict | 231 | 1 | S → P in AAM65958. Ref.5 | ||||||
| Sequence conflict | 428 | 1 | D → E in AAD00360. Ref.1 | ||||||
| Sequence conflict | 452 | 1 | S → P in AAM65958. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans." Schmidt S.R., Werner E., Mueller C.R., Kress W. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. |
| [2] | Schmidt S.R. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S. DNA Res. 7:31-63(2000) [PubMed: 10718197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| U80668 mRNA. Translation: AAD00360.1. AF130845 Genomic DNA. Translation: AAF36499.1. AB018115 Genomic DNA. Translation: BAA97130.1. AY140075 mRNA. Translation: AAM98216.1. BT010329 mRNA. Translation: AAQ55280.1. AY088421 mRNA. Translation: AAM65958.1. | |
| RefSeq | NP_200219.1. NP_851187.1. |
| UniGene | At.23160 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EYB based on UniProtKB Q93099. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 835494. |
| GenomeReviews | Gene locus AT5G54080 in contig BA000015_GR. |
| KEGG | ath:AT5G54080. |
| NMPDR | fig|3702.1.peg.27312. |
Organism-specific databases | |
| TAIR | At5g54080. |
Gene expression databases | |
| ArrayExpress | Q9ZRA2. |
| GermOnline | AT5G54080. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR005708. Homogentis_dOase. [Graphical view] |
| PANTHER | PTHR11056. Homogentis_dOase. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| BLOCKS | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | HGD_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9ZRA2 Secondary accession number(s): Q8L9I0, Q9LDB8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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