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Q9ZRA2

- HGD_ARATH

UniProt

Q9ZRA2 - HGD_ARATH

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Protein

Homogentisate 1,2-dioxygenase

Gene
HGO, At5g54080, MJP23.6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Iron.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi341 – 3411Iron By similarity
Metal bindingi347 – 3471Iron By similarity
Metal bindingi377 – 3771Iron By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. homogentisate catabolic process Source: TAIR
  2. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  3. tyrosine catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G54080-MONOMER.
ARA:GQT-2804-MONOMER.
BRENDAi1.13.11.5. 399.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:HGO
Ordered Locus Names:At5g54080
ORF Names:MJP23.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G54080.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Homogentisate 1,2-dioxygenasePRO_0000220244Add
BLAST

Proteomic databases

PaxDbiQ9ZRA2.
PRIDEiQ9ZRA2.

Expressioni

Gene expression databases

GenevestigatoriQ9ZRA2.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRA2.
SMRiQ9ZRA2. Positions 10-441.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ9ZRA2.
KOiK00451.
OMAiRCFYNSD.
PhylomeDBiQ9ZRA2.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZRA2-1 [UniParc]FASTAAdd to Basket

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MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS    50
GTSFTSPRKL NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN 100
PTQLRWRPED IPDSEIDFVD GLFTICGAGS SFLRHGFAIH MYVANTGMKD 150
SAFCNADGDF LLVPQTGRLW IETECGRLLV TPGEIAVIPQ GFRFSIDLPD 200
GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW FEDGLRPEYT 250
IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD 300
PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG 350
LIYGAYEAKA DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT 400
GTMAFMFESA LIPRVCHWAL ESPFLDHDYY QCWIGLKSHF SRISLDKTNV 450
ESTEKEPGAS E 461
Length:461
Mass (Da):51,455
Last modified:April 27, 2001 - v2
Checksum:iCD90DD9638014D31
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71E → K in AAM65958. 1 Publication
Sequence conflicti69 – 691V → I in AAM65958. 1 Publication
Sequence conflicti116 – 1161I → T in AAM65958. 1 Publication
Sequence conflicti146 – 1461T → K in AAM65958. 1 Publication
Sequence conflicti181 – 1811T → S in AAM65958. 1 Publication
Sequence conflicti231 – 2311S → P in AAM65958. 1 Publication
Sequence conflicti428 – 4281D → E in AAD00360. 1 Publication
Sequence conflicti452 – 4521S → P in AAM65958. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80668 mRNA. Translation: AAD00360.1.
AF130845 Genomic DNA. Translation: AAF36499.1.
AB018115 Genomic DNA. Translation: BAA97130.1.
CP002688 Genomic DNA. Translation: AED96447.1.
CP002688 Genomic DNA. Translation: AED96448.1.
AY140075 mRNA. Translation: AAM98216.1.
BT010329 mRNA. Translation: AAQ55280.1.
AY088421 mRNA. Translation: AAM65958.1.
RefSeqiNP_200219.1. NM_124787.3.
NP_851187.1. NM_180856.3.
UniGeneiAt.23160.
At.72265.

Genome annotation databases

EnsemblPlantsiAT5G54080.1; AT5G54080.1; AT5G54080.
AT5G54080.2; AT5G54080.2; AT5G54080.
GeneIDi835494.
KEGGiath:AT5G54080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U80668 mRNA. Translation: AAD00360.1 .
AF130845 Genomic DNA. Translation: AAF36499.1 .
AB018115 Genomic DNA. Translation: BAA97130.1 .
CP002688 Genomic DNA. Translation: AED96447.1 .
CP002688 Genomic DNA. Translation: AED96448.1 .
AY140075 mRNA. Translation: AAM98216.1 .
BT010329 mRNA. Translation: AAQ55280.1 .
AY088421 mRNA. Translation: AAM65958.1 .
RefSeqi NP_200219.1. NM_124787.3.
NP_851187.1. NM_180856.3.
UniGenei At.23160.
At.72265.

3D structure databases

ProteinModelPortali Q9ZRA2.
SMRi Q9ZRA2. Positions 10-441.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9ZRA2.
PRIDEi Q9ZRA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G54080.1 ; AT5G54080.1 ; AT5G54080 .
AT5G54080.2 ; AT5G54080.2 ; AT5G54080 .
GeneIDi 835494.
KEGGi ath:AT5G54080.

Organism-specific databases

TAIRi AT5G54080.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
InParanoidi Q9ZRA2.
KOi K00451.
OMAi RCFYNSD.
PhylomeDBi Q9ZRA2.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci ARA:AT5G54080-MONOMER.
ARA:GQT-2804-MONOMER.
BRENDAi 1.13.11.5. 399.

Miscellaneous databases

PROi Q9ZRA2.

Gene expression databases

Genevestigatori Q9ZRA2.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
    Schmidt S.R., Werner E., Mueller C.R., Kress W.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Schmidt S.R.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHGD_ARATH
AccessioniPrimary (citable) accession number: Q9ZRA2
Secondary accession number(s): Q8L9I0, Q9LDB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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