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Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi341 – 3411IronBy similarity
Metal bindingi347 – 3471IronBy similarity
Metal bindingi377 – 3771IronBy similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: TAIR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. homogentisate catabolic process Source: TAIR
  2. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  3. tyrosine catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G54080-MONOMER.
ARA:GQT-2804-MONOMER.
BRENDAi1.13.11.5. 399.
ReactomeiREACT_258218. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:HGO
Ordered Locus Names:At5g54080
ORF Names:MJP23.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G54080.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Homogentisate 1,2-dioxygenasePRO_0000220244Add
BLAST

Proteomic databases

PaxDbiQ9ZRA2.
PRIDEiQ9ZRA2.

Expressioni

Gene expression databases

GenevestigatoriQ9ZRA2.

Structurei

3D structure databases

ProteinModelPortaliQ9ZRA2.
SMRiQ9ZRA2. Positions 10-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ9ZRA2.
KOiK00451.
OMAiRGYLCEN.
PhylomeDBiQ9ZRA2.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZRA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS
60 70 80 90 100
GTSFTSPRKL NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN
110 120 130 140 150
PTQLRWRPED IPDSEIDFVD GLFTICGAGS SFLRHGFAIH MYVANTGMKD
160 170 180 190 200
SAFCNADGDF LLVPQTGRLW IETECGRLLV TPGEIAVIPQ GFRFSIDLPD
210 220 230 240 250
GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW FEDGLRPEYT
260 270 280 290 300
IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD
310 320 330 340 350
PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG
360 370 380 390 400
LIYGAYEAKA DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT
410 420 430 440 450
GTMAFMFESA LIPRVCHWAL ESPFLDHDYY QCWIGLKSHF SRISLDKTNV
460
ESTEKEPGAS E
Length:461
Mass (Da):51,455
Last modified:April 27, 2001 - v2
Checksum:iCD90DD9638014D31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71E → K in AAM65958 (Ref. 6) Curated
Sequence conflicti69 – 691V → I in AAM65958 (Ref. 6) Curated
Sequence conflicti116 – 1161I → T in AAM65958 (Ref. 6) Curated
Sequence conflicti146 – 1461T → K in AAM65958 (Ref. 6) Curated
Sequence conflicti181 – 1811T → S in AAM65958 (Ref. 6) Curated
Sequence conflicti231 – 2311S → P in AAM65958 (Ref. 6) Curated
Sequence conflicti428 – 4281D → E in AAD00360 (Ref. 1) Curated
Sequence conflicti452 – 4521S → P in AAM65958 (Ref. 6) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80668 mRNA. Translation: AAD00360.1.
AF130845 Genomic DNA. Translation: AAF36499.1.
AB018115 Genomic DNA. Translation: BAA97130.1.
CP002688 Genomic DNA. Translation: AED96447.1.
CP002688 Genomic DNA. Translation: AED96448.1.
AY140075 mRNA. Translation: AAM98216.1.
BT010329 mRNA. Translation: AAQ55280.1.
AY088421 mRNA. Translation: AAM65958.1.
RefSeqiNP_200219.1. NM_124787.3.
NP_851187.1. NM_180856.3.
UniGeneiAt.23160.
At.72265.

Genome annotation databases

EnsemblPlantsiAT5G54080.1; AT5G54080.1; AT5G54080.
AT5G54080.2; AT5G54080.2; AT5G54080.
GeneIDi835494.
KEGGiath:AT5G54080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80668 mRNA. Translation: AAD00360.1.
AF130845 Genomic DNA. Translation: AAF36499.1.
AB018115 Genomic DNA. Translation: BAA97130.1.
CP002688 Genomic DNA. Translation: AED96447.1.
CP002688 Genomic DNA. Translation: AED96448.1.
AY140075 mRNA. Translation: AAM98216.1.
BT010329 mRNA. Translation: AAQ55280.1.
AY088421 mRNA. Translation: AAM65958.1.
RefSeqiNP_200219.1. NM_124787.3.
NP_851187.1. NM_180856.3.
UniGeneiAt.23160.
At.72265.

3D structure databases

ProteinModelPortaliQ9ZRA2.
SMRiQ9ZRA2. Positions 10-441.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9ZRA2.
PRIDEiQ9ZRA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G54080.1; AT5G54080.1; AT5G54080.
AT5G54080.2; AT5G54080.2; AT5G54080.
GeneIDi835494.
KEGGiath:AT5G54080.

Organism-specific databases

TAIRiAT5G54080.

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ9ZRA2.
KOiK00451.
OMAiRGYLCEN.
PhylomeDBiQ9ZRA2.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.
BioCyciARA:AT5G54080-MONOMER.
ARA:GQT-2804-MONOMER.
BRENDAi1.13.11.5. 399.
ReactomeiREACT_258218. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

PROiQ9ZRA2.

Gene expression databases

GenevestigatoriQ9ZRA2.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
    Schmidt S.R., Werner E., Mueller C.R., Kress W.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Schmidt S.R.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHGD_ARATH
AccessioniPrimary (citable) accession number: Q9ZRA2
Secondary accession number(s): Q8L9I0, Q9LDB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: January 7, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.