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Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Tyrosine aminotransferase (TAT)
  3. 4-hydroxyphenylpyruvate dioxygenase (HPD)
  4. Homogentisate 1,2-dioxygenase (HGO)
  5. no protein annotated in this organism
  6. Fumarylacetoacetase (FAH)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi341IronBy similarity1
Metal bindingi347IronBy similarity1
Metal bindingi377IronBy similarity1

GO - Molecular functioni

  • homogentisate 1,2-dioxygenase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • homogentisate catabolic process Source: TAIR
  • L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  • tyrosine catabolic process Source: TAIR

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G54080-MONOMER
BRENDAi1.13.11.5 399
ReactomeiR-ATH-71182 Phenylalanine and tyrosine catabolism
UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:HGO
Ordered Locus Names:At5g54080
ORF Names:MJP23.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G54080
TAIRilocus:2166567 AT5G54080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002202441 – 461Homogentisate 1,2-dioxygenaseAdd BLAST461

Proteomic databases

PaxDbiQ9ZRA2

PTM databases

iPTMnetiQ9ZRA2

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZRA2 baseline and differential
GenevisibleiQ9ZRA2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G54080.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZRA2
SMRiQ9ZRA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1417 Eukaryota
COG3508 LUCA
HOGENOMiHOG000139824
InParanoidiQ9ZRA2
KOiK00451
OMAiHGNYTPY
OrthoDBiEOG0936072X
PhylomeDBiQ9ZRA2

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZRA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS
60 70 80 90 100
GTSFTSPRKL NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN
110 120 130 140 150
PTQLRWRPED IPDSEIDFVD GLFTICGAGS SFLRHGFAIH MYVANTGMKD
160 170 180 190 200
SAFCNADGDF LLVPQTGRLW IETECGRLLV TPGEIAVIPQ GFRFSIDLPD
210 220 230 240 250
GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW FEDGLRPEYT
260 270 280 290 300
IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD
310 320 330 340 350
PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG
360 370 380 390 400
LIYGAYEAKA DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT
410 420 430 440 450
GTMAFMFESA LIPRVCHWAL ESPFLDHDYY QCWIGLKSHF SRISLDKTNV
460
ESTEKEPGAS E
Length:461
Mass (Da):51,455
Last modified:April 27, 2001 - v2
Checksum:iCD90DD9638014D31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7E → K in AAM65958 (Ref. 6) Curated1
Sequence conflicti69V → I in AAM65958 (Ref. 6) Curated1
Sequence conflicti116I → T in AAM65958 (Ref. 6) Curated1
Sequence conflicti146T → K in AAM65958 (Ref. 6) Curated1
Sequence conflicti181T → S in AAM65958 (Ref. 6) Curated1
Sequence conflicti231S → P in AAM65958 (Ref. 6) Curated1
Sequence conflicti428D → E in AAD00360 (Ref. 1) Curated1
Sequence conflicti452S → P in AAM65958 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80668 mRNA Translation: AAD00360.1
AF130845 Genomic DNA Translation: AAF36499.1
AB018115 Genomic DNA Translation: BAA97130.1
CP002688 Genomic DNA Translation: AED96447.1
CP002688 Genomic DNA Translation: AED96448.1
AY140075 mRNA Translation: AAM98216.1
BT010329 mRNA Translation: AAQ55280.1
AY088421 mRNA Translation: AAM65958.1
RefSeqiNP_200219.1, NM_124787.4
NP_851187.1, NM_180856.4
UniGeneiAt.23160
At.72265

Genome annotation databases

EnsemblPlantsiAT5G54080.1; AT5G54080.1; AT5G54080
AT5G54080.2; AT5G54080.2; AT5G54080
GeneIDi835494
GrameneiAT5G54080.1; AT5G54080.1; AT5G54080
AT5G54080.2; AT5G54080.2; AT5G54080
KEGGiath:AT5G54080

Similar proteinsi

Entry informationi

Entry nameiHGD_ARATH
AccessioniPrimary (citable) accession number: Q9ZRA2
Secondary accession number(s): Q8L9I0, Q9LDB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: April 25, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health