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Q9ZRA2

- HGD_ARATH

UniProt

Q9ZRA2 - HGD_ARATH

Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.

    Cofactori

    Iron.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi341 – 3411IronBy similarity
    Metal bindingi347 – 3471IronBy similarity
    Metal bindingi377 – 3771IronBy similarity

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: TAIR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. homogentisate catabolic process Source: TAIR
    2. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    3. tyrosine catabolic process Source: TAIR

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G54080-MONOMER.
    ARA:GQT-2804-MONOMER.
    BRENDAi1.13.11.5. 399.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
    Alternative name(s):
    Homogentisate oxygenase
    Homogentisic acid oxidase
    Homogentisicase
    Gene namesi
    Name:HGO
    Ordered Locus Names:At5g54080
    ORF Names:MJP23.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G54080.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Homogentisate 1,2-dioxygenasePRO_0000220244Add
    BLAST

    Proteomic databases

    PaxDbiQ9ZRA2.
    PRIDEiQ9ZRA2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ZRA2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZRA2.
    SMRiQ9ZRA2. Positions 10-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    InParanoidiQ9ZRA2.
    KOiK00451.
    OMAiRCFYNSD.
    PhylomeDBiQ9ZRA2.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZRA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS    50
    GTSFTSPRKL NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN 100
    PTQLRWRPED IPDSEIDFVD GLFTICGAGS SFLRHGFAIH MYVANTGMKD 150
    SAFCNADGDF LLVPQTGRLW IETECGRLLV TPGEIAVIPQ GFRFSIDLPD 200
    GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW FEDGLRPEYT 250
    IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD 300
    PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG 350
    LIYGAYEAKA DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT 400
    GTMAFMFESA LIPRVCHWAL ESPFLDHDYY QCWIGLKSHF SRISLDKTNV 450
    ESTEKEPGAS E 461
    Length:461
    Mass (Da):51,455
    Last modified:April 27, 2001 - v2
    Checksum:iCD90DD9638014D31
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71E → K in AAM65958. 1 PublicationCurated
    Sequence conflicti69 – 691V → I in AAM65958. 1 PublicationCurated
    Sequence conflicti116 – 1161I → T in AAM65958. 1 PublicationCurated
    Sequence conflicti146 – 1461T → K in AAM65958. 1 PublicationCurated
    Sequence conflicti181 – 1811T → S in AAM65958. 1 PublicationCurated
    Sequence conflicti231 – 2311S → P in AAM65958. 1 PublicationCurated
    Sequence conflicti428 – 4281D → E in AAD00360. 1 PublicationCurated
    Sequence conflicti452 – 4521S → P in AAM65958. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U80668 mRNA. Translation: AAD00360.1.
    AF130845 Genomic DNA. Translation: AAF36499.1.
    AB018115 Genomic DNA. Translation: BAA97130.1.
    CP002688 Genomic DNA. Translation: AED96447.1.
    CP002688 Genomic DNA. Translation: AED96448.1.
    AY140075 mRNA. Translation: AAM98216.1.
    BT010329 mRNA. Translation: AAQ55280.1.
    AY088421 mRNA. Translation: AAM65958.1.
    RefSeqiNP_200219.1. NM_124787.3.
    NP_851187.1. NM_180856.3.
    UniGeneiAt.23160.
    At.72265.

    Genome annotation databases

    EnsemblPlantsiAT5G54080.1; AT5G54080.1; AT5G54080.
    AT5G54080.2; AT5G54080.2; AT5G54080.
    GeneIDi835494.
    KEGGiath:AT5G54080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U80668 mRNA. Translation: AAD00360.1 .
    AF130845 Genomic DNA. Translation: AAF36499.1 .
    AB018115 Genomic DNA. Translation: BAA97130.1 .
    CP002688 Genomic DNA. Translation: AED96447.1 .
    CP002688 Genomic DNA. Translation: AED96448.1 .
    AY140075 mRNA. Translation: AAM98216.1 .
    BT010329 mRNA. Translation: AAQ55280.1 .
    AY088421 mRNA. Translation: AAM65958.1 .
    RefSeqi NP_200219.1. NM_124787.3.
    NP_851187.1. NM_180856.3.
    UniGenei At.23160.
    At.72265.

    3D structure databases

    ProteinModelPortali Q9ZRA2.
    SMRi Q9ZRA2. Positions 10-441.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9ZRA2.
    PRIDEi Q9ZRA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G54080.1 ; AT5G54080.1 ; AT5G54080 .
    AT5G54080.2 ; AT5G54080.2 ; AT5G54080 .
    GeneIDi 835494.
    KEGGi ath:AT5G54080.

    Organism-specific databases

    TAIRi AT5G54080.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    InParanoidi Q9ZRA2.
    KOi K00451.
    OMAi RCFYNSD.
    PhylomeDBi Q9ZRA2.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci ARA:AT5G54080-MONOMER.
    ARA:GQT-2804-MONOMER.
    BRENDAi 1.13.11.5. 399.

    Miscellaneous databases

    PROi Q9ZRA2.

    Gene expression databases

    Genevestigatori Q9ZRA2.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
      Schmidt S.R., Werner E., Mueller C.R., Kress W.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. Schmidt S.R.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHGD_ARATH
    AccessioniPrimary (citable) accession number: Q9ZRA2
    Secondary accession number(s): Q8L9I0, Q9LDB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3