Reviewed, UniProtKB/Swiss-Prot Q9ZQP2 (ACO12_ARATH)

Names and origin

Protein names

Recommended name:
    Putative peroxisomal acyl-coenzyme A oxidase 1.2
    EC=1.3.3.6

Gene names

Name:	ACX1.2
Ordered Locus Names:	At2g35690
ORF Names:	T20F21.12

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	664 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs By similarity.
Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Subcellular location	Peroxisome Probable.
Induction	Not induced by wounding. Ref.3
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	defense response to insect Inferred from genetic interaction. Source: TAIR fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro jasmonic acid biosynthetic process Inferred from genetic interaction. Source: TAIR oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pollen development Inferred from genetic interaction. Source: TAIR
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 664	664	Putative peroxisomal acyl-coenzyme A oxidase 1.2		PRO_0000204690
Regions
	Nucleotide binding	399 – 404	6	FAD By similarity
	Motif	662 – 664	3	Microbody targeting signal Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZQP2-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: E523BC625944A7AA	FASTA	664	74,298
	10 20 30 40 50 60 MERVDHLADE RNKAEFNVDD MKIVWAGSRH AFDVSNRMSR LVANDPVFEK SKRAVMSRKE 70 80 90 100 110 120 LFKNTLRKSV HAWKLINELR LSDEEGLKLR SFMDQPGFLD LHWGMFVPAI KGQGTEQQQQ 130 140 150 160 170 180 KWLSLATKMQ IIGCYAQTEL GHGSNVQGLE TTATFDPKTD QFIIHSPTQT SSKWWPGGLG 190 200 210 220 230 240 KVSTHAVIYA RLITNGKDHG VHGFIVQLRS LDDHSPLPGI TVGDIGMKFG NGAYNSMDNG 250 260 270 280 290 300 FLMFDHFRIP RDQMLMRLSK VTREGKYVAS DVPRQLVYGT MVYVRQSIVS NASTALARAV 310 320 330 340 350 360 CIATRYSAVR RQFGSHDGGI ETQVINYKTQ QNRLFPLLAS AYAFRFVGEW LKWLYTDVTK 370 380 390 400 410 420 RLEASDFATL PEAHACTAGL KSMTTSATSD GIEECRKLCG GHGYLWCSGL PELFAVYVPA 430 440 450 460 470 480 CTYEGDNVVL QLQVARFLMK TVSQLGSGKA PSGTTAYMGR AKHLLQCSSG VRNARDWLNP 490 500 510 520 530 540 GMVLEAFEAR ALRMAVTCAN NLSKFENQEQ GFSELLADLV EAATAHCQLI VVSKFIAKVE 550 560 570 580 590 600 GDIEGKGVKK QLKNLCYIYA LYLLHKHLGD FLSTNSVTPE QASLANQQLR SLYSQVRPNA 610 620 630 640 650 660 VALVDAFDYT DQYLGSVLGR YDGNVYPKLF EEALKDPLND SVVPDGYREY IRPLIKQRFR SAKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Gene-specific involvement of beta-oxidation in wound-activated responses in Arabidopsis." Cruz-Castillo M., Martinez C., Buchala A., Metraux J.-P., Leon J. Plant Physiol. 135:85-94(2004) [PubMed: 15141068] [Abstract] Cited for: IDENTIFICATION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC006068 Genomic DNA. Translation: AAD15446.1. AY074357 mRNA. Translation: AAL67053.1. AY096691 mRNA. Translation: AAM20325.1.
IPI	IPI00520398.
PIR	G84771.
RefSeq	NP_181112.1.
UniGene	At.37640
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
SMR	Q9ZQP2. Positions 2-659.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZQP2.
Proteomic databases
PRIDE	Q9ZQP2.
Genome annotation databases
GeneID	818138.
GenomeReviews	Gene locus AT2G35690 in contig CT485783_GR.
KEGG	ath:AT2G35690.
NMPDR	fig|3702.1.peg.10667.
Organism-specific databases
TAIR	At2g35690.
Phylogenomic databases
OMA	MVQIRLL.
Enzyme and pathway databases
BRENDA	1.3.3.6. 302.
Gene expression databases
ArrayExpress	Q9ZQP2.
Genevestigator	Q9ZQP2.
GermOnline	AT2G35690. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACO12_ARATH

Accession

Primary (citable) accession number: Q9ZQP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)