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Protein

Putative dual specificity protein phosphatase DSP8

Gene

DSP8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May possess phosphatase activity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: GO_Central
  2. protein tyrosine/serine/threonine phosphatase activity Source: GO_Central
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inositol phosphate dephosphorylation Source: GO_Central
  2. protein dephosphorylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciARA:AT2G35680-MONOMER.
ReactomeiREACT_348459. Synthesis of PG.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dual specificity protein phosphatase DSP8 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:DSP8
Ordered Locus Names:At2g35680
ORF Names:T20F21.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G35680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Putative dual specificity protein phosphatase DSP8PRO_0000417332Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ9ZQP1.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G35680.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZQP1.
SMRiQ9ZQP1. Positions 73-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 219147Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni164 – 1707Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000238257.
InParanoidiQ9ZQP1.
OMAiHTDQKIP.
PhylomeDBiQ9ZQP1.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZQP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIKELTETD EEKRERSVED NVDDGDKAVL VSRGNVIVLT TKRALVGVGA
60 70 80 90 100
RALFYPTLVY NVVRNKLESE FRWWDRVAEF ILLGAVPFPS DVPQLKELGV
110 120 130 140 150
CGVITLNEPY ETLVPSSLYK SYCIDHLVIA TRDYCFAPSM EAICQAVEFI
160 170 180 190 200
HRNASLGKTT YVHCKAGRGR STTIVICYLV QHKNMTPEAA YSYVRSIRPR
210 220 230 240 250
VLLAAAQWKA VVEYYHVKVL NTQSCLTDAT SALIPRNVKQ VCSGNVVVFD
260 270 280 290 300
DGSMVVVTHS DLEGYNDDDS RSRRSVKVNG NELWAAAADL SMVYRVKVVG
310 320 330
QAAMARISCL WLGLREDQKL SGKNLSMGGI SVDISVY
Length:337
Mass (Da):37,548
Last modified:June 1, 2002 - v2
Checksum:i8A11D39F2772D2A2
GO

Sequence cautioni

The sequence AAK96749.1 differs from that shown. Reason: Frameshift at position 239. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ574761 mRNA. Translation: CAE00415.1.
AC006068 Genomic DNA. Translation: AAD15447.2.
CP002685 Genomic DNA. Translation: AEC09144.1.
AY054558 mRNA. Translation: AAK96749.1. Frameshift.
AY065219 mRNA. Translation: AAL38695.1.
BT008574 mRNA. Translation: AAP40401.1.
PIRiF84771.
RefSeqiNP_565816.1. NM_129123.2.
UniGeneiAt.23626.
At.71304.

Genome annotation databases

EnsemblPlantsiAT2G35680.1; AT2G35680.1; AT2G35680.
GeneIDi818137.
KEGGiath:AT2G35680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ574761 mRNA. Translation: CAE00415.1.
AC006068 Genomic DNA. Translation: AAD15447.2.
CP002685 Genomic DNA. Translation: AEC09144.1.
AY054558 mRNA. Translation: AAK96749.1. Frameshift.
AY065219 mRNA. Translation: AAL38695.1.
BT008574 mRNA. Translation: AAP40401.1.
PIRiF84771.
RefSeqiNP_565816.1. NM_129123.2.
UniGeneiAt.23626.
At.71304.

3D structure databases

ProteinModelPortaliQ9ZQP1.
SMRiQ9ZQP1. Positions 73-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G35680.1-P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G35680.1; AT2G35680.1; AT2G35680.
GeneIDi818137.
KEGGiath:AT2G35680.

Organism-specific databases

TAIRiAT2G35680.

Phylogenomic databases

HOGENOMiHOG000238257.
InParanoidiQ9ZQP1.
OMAiHTDQKIP.
PhylomeDBiQ9ZQP1.

Enzyme and pathway databases

BioCyciARA:AT2G35680-MONOMER.
ReactomeiREACT_348459. Synthesis of PG.

Miscellaneous databases

PROiQ9ZQP1.

Gene expression databases

GenevestigatoriQ9ZQP1.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A stress inducible dual-specific phosphatase that plays a role in ABA and sugar signaling."
    Gupta R., Sokolov L.N., Luan S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiDSP8_ARATH
AccessioniPrimary (citable) accession number: Q9ZQP1
Secondary accession number(s): Q8VZ64, Q940J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.