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Protein

Exportin-2

Gene

CAS

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-2
Short name:
Exp2
Alternative name(s):
Cellular apoptosis susceptibility protein homolog
Importin-alpha re-exporter
Gene namesi
Name:CAS
Ordered Locus Names:At2g46520
ORF Names:F11C10, F13A10.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G46520.
TAIRilocus:2039109. AT2G46520.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001172911 – 972Exportin-2Add BLAST972

Proteomic databases

PaxDbiQ9ZPY7.
PRIDEiQ9ZPY7.

PTM databases

SwissPalmiQ9ZPY7.

Expressioni

Gene expression databases

GenevisibleiQ9ZPY7. AT.

Interactioni

Subunit structurei

Binds with high affinity to importin-alpha only in the presence of RanGTP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4598. 1 interactor.
STRINGi3702.AT2G46520.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPY7.
SMRiQ9ZPY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 104Importin N-terminalPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated

Phylogenomic databases

eggNOGiKOG1992. Eukaryota.
COG5657. LUCA.
HOGENOMiHOG000201317.
InParanoidiQ9ZPY7.
KOiK18423.
OMAiFMPYVFQ.
OrthoDBiEOG0936016J.
PhylomeDBiQ9ZPY7.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR005043. CAS_CSE1_C.
IPR013713. Cse1.
IPR001494. Importin-beta_N.
PfamiView protein in Pfam
PF03378. CAS_CSE1. 1 hit.
PF08506. Cse1. 1 hit.
PF03810. IBN_N. 1 hit.
SMARTiView protein in SMART
SM00913. IBN_N. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50166. IMPORTIN_B_NT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZPY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWNRETLVF LSQCFLNTLS PIPEPRRTAE RALSDAADQA NYGLAVLRLV
60 70 80 90 100
AEPAIDEQTR HAAAVNFKNH LRSRWHPAGD SGISPIVDSE KEQIKTLIVS
110 120 130 140 150
LMLSASPRIQ SQLSEALTVI GKHDFPKAWP ALLPELIANL QNAALAGDYV
160 170 180 190 200
SVNGILGTAS SIFKKFSYEY RTDALFVDLK YCLDNFAAPL TEIFLKTSSL
210 220 230 240 250
IDSAASSGGS PPILKPLFES QRLCCTIFYS LNFQDLPEFF EDHMKEWMGE
260 270 280 290 300
FKKYLSSNYP ALESTEEGLT LVDDLRAAIC ENINHYIEKN EEEFQGFLNE
310 320 330 340 350
FASVVWTLLR DVSKSPSRDQ LATTAIKFLT SVSTSVHHAL FAGDNVIKEI
360 370 380 390 400
CQSIVIPNVS LRVEDEEIFE MNYIEFIRRD MEGSDVDTRR RIACELLKGL
410 420 430 440 450
ATNYKTQVTE VVSLEIQRLL SSFSANPSAN WKDKDCAIYL VVSLSTKKAG
460 470 480 490 500
GASVSTDLID VQNFFANIIL PELQSRDVNS FPMLKAGSLK FLTMFRSHIP
510 520 530 540 550
KPFAMQLFPE LVRFLKAESN VVHSYAASCI EKLLLVKEEG ARGNRYAAGD
560 570 580 590 600
LSPFLLQLMT NLFDALKFPE SEENQYLMKC IMRVLGVADI SAEVAGPCIG
610 620 630 640 650
GLTSILSEVC KNPKNPIFNH YLFESVAVLV RRACERDISL ISAFETSLFP
660 670 680 690 700
SLQMILANDI TEFLPYGFQL LAQLVELNRP TLSPNYMQIF LLLLSPESWK
710 720 730 740 750
RSGNVPALVR LLQAFLQKAP HEVTQENRLS QVLGIFEKLV ASPSTDEQGF
760 770 780 790 800
YILNTIIENL DYSVIAPYMK GVWSALFTRV QNKKTVKFQK SLVIFMSLFL
810 820 830 840 850
VKHGQAYLVE TMNTVQPNII TAIVEHFWIP NLKLIMGSME VKLTAVAATR
860 870 880 890 900
LICETPALLD PSAAKLWGKM LDSIVTLVSR PEQERVLDEP EMPEISENVG
910 920 930 940 950
YTAAFVKLHN AGKKEEDPLK DIKDPKQFLV ASVSRLSSAS PGRYPQIIGE
960 970
NLEQANQTAL IQLCNAYNCG IA
Length:972
Mass (Da):108,657
Last modified:May 1, 1999 - v1
Checksum:iA0D9C38E4E1EFBCE
GO

Sequence cautioni

The sequence BAD95016 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti787K → R in BAD95016 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297282 mRNA. Translation: CAC83300.1.
AC006418 Genomic DNA. Translation: AAD20163.1.
AC006526 Genomic DNA. Translation: AAM15266.1.
CP002685 Genomic DNA. Translation: AEC10713.1.
AK222100 mRNA. Translation: BAD95016.1. Different initiation.
PIRiH84903.
RefSeqiNP_182175.1. NM_130217.4.
UniGeneiAt.36499.
At.67632.

Genome annotation databases

EnsemblPlantsiAT2G46520.1; AT2G46520.1; AT2G46520.
GeneIDi819263.
GrameneiAT2G46520.1; AT2G46520.1; AT2G46520.
KEGGiath:AT2G46520.

Similar proteinsi

Entry informationi

Entry nameiXPO2_ARATH
AccessioniPrimary (citable) accession number: Q9ZPY7
Secondary accession number(s): Q56WE2, Q7GA14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families