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Q9ZPY1

- PPOX2_ARATH

UniProt

Q9ZPY1 - PPOX2_ARATH

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Protein
Pyridoxine/pyridoxamine 5'-phosphate oxidase 2
Gene
PPOX2, At2g46580, F13A10.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Has an in vitro catalytic efficiency for PNP approximately 300-fold lower than that of PPOX1.1 Publication

Catalytic activityi

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.1 Publication
Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.1 Publication

Cofactori

Binds 1 FMN per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421FMN By similarity
Binding sitei66 – 661FMN By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 602FMN By similarity
Nucleotide bindingi121 – 1222FMN By similarity

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. pyridoxamine-phosphate oxidase activity Source: UniProtKB

GO - Biological processi

  1. pyridoxal 5'-phosphate salvage Source: UniProtKB
  2. pyridoxine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00190; UER00304.
UPA00190; UER00305.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine/pyridoxamine 5'-phosphate oxidase 2 (EC:1.4.3.5)
Short name:
AtPPOX1
Gene namesi
Name:PPOX2
Ordered Locus Names:At2g46580
ORF Names:F13A10.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G46580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Pyridoxine/pyridoxamine 5'-phosphate oxidase 2
PRO_0000420550Add
BLAST

Proteomic databases

PaxDbiQ9ZPY1.
PRIDEiQ9ZPY1.

Expressioni

Gene expression databases

GenevestigatoriQ9ZPY1.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi3702.AT2G46580.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPY1.
SMRiQ9ZPY1. Positions 2-198.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 1614Poly-Leu

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5135.
HOGENOMiHOG000233130.
InParanoidiQ9ZPY1.
OMAiNYVEECA.
PhylomeDBiQ9ZPY1.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR000659. Pyridox_Oxase.
IPR024624. Pyridox_Oxase_Alr4036_FMN-bd.
IPR024015. Pyridox_Oxase_FMN-dep_Alr4036.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERiPTHR10851. PTHR10851. 1 hit.
PfamiPF12766. Pyridox_oxase_2. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR04026. PPOX_FMN_cyano. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZPY1-1 [UniParc]FASTAAdd to Basket

« Hide

MGTHVAPWKQ LLFGAIEANS HLSHSSYVQL ATIGLNGRPS NRTVVFRGFE    50
ENSDRIQINT DLRSRKIEEL KHCPFSEMCW YFSDTWEQFR INGRIEVIDA 100
SNPDQTKLQQ REKAWFANSL RSRLIYVCPT PGSPCNSEQS SQQVKLDPSS 150
GPVPEYCLLL LEPEKVDYLN LKTNQRLFFS SMATGTGEKC WTSEKVNP 198
Length:198
Mass (Da):22,620
Last modified:June 1, 2002 - v2
Checksum:iEFDE8DA20D6A4376
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006418 Genomic DNA. Translation: AAD20168.2.
CP002685 Genomic DNA. Translation: AEC10724.1.
AY086412 mRNA. Translation: AAM63414.1.
BT024917 mRNA. Translation: ABD94073.1.
PIRiF84904.
RefSeqiNP_566081.1. NM_130223.2.
UniGeneiAt.21431.

Genome annotation databases

EnsemblPlantsiAT2G46580.1; AT2G46580.1; AT2G46580.
GeneIDi819270.
KEGGiath:AT2G46580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006418 Genomic DNA. Translation: AAD20168.2 .
CP002685 Genomic DNA. Translation: AEC10724.1 .
AY086412 mRNA. Translation: AAM63414.1 .
BT024917 mRNA. Translation: ABD94073.1 .
PIRi F84904.
RefSeqi NP_566081.1. NM_130223.2.
UniGenei At.21431.

3D structure databases

ProteinModelPortali Q9ZPY1.
SMRi Q9ZPY1. Positions 2-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G46580.1-P.

Proteomic databases

PaxDbi Q9ZPY1.
PRIDEi Q9ZPY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G46580.1 ; AT2G46580.1 ; AT2G46580 .
GeneIDi 819270.
KEGGi ath:AT2G46580.

Organism-specific databases

TAIRi AT2G46580.

Phylogenomic databases

eggNOGi COG5135.
HOGENOMi HOG000233130.
InParanoidi Q9ZPY1.
OMAi NYVEECA.
PhylomeDBi Q9ZPY1.

Enzyme and pathway databases

UniPathwayi UPA00190 ; UER00304 .
UPA00190 ; UER00305 .

Miscellaneous databases

PROi Q9ZPY1.

Gene expression databases

Genevestigatori Q9ZPY1.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
InterProi IPR000659. Pyridox_Oxase.
IPR024624. Pyridox_Oxase_Alr4036_FMN-bd.
IPR024015. Pyridox_Oxase_FMN-dep_Alr4036.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
PANTHERi PTHR10851. PTHR10851. 1 hit.
Pfami PF12766. Pyridox_oxase_2. 1 hit.
[Graphical view ]
SUPFAMi SSF50475. SSF50475. 1 hit.
TIGRFAMsi TIGR04026. PPOX_FMN_cyano. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Kim C.J., Ecker J.R.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification of a second pyridoxine (pyridoxamine) 50-phosphate oxidase in Arabidopsis thaliana."
    Sang Y., Goertzen L.R., Tzou Y.-M., Locy R.D., Singh N.K.
    Acta Physiol. Plant. 33:559-566(2011)
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiPPOX2_ARATH
AccessioniPrimary (citable) accession number: Q9ZPY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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