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Q9ZPY1

- PPOX2_ARATH

UniProt

Q9ZPY1 - PPOX2_ARATH

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Protein

Pyridoxine/pyridoxamine 5'-phosphate oxidase 2

Gene

PPOX2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Has an in vitro catalytic efficiency for PNP approximately 300-fold lower than that of PPOX1.1 Publication

Catalytic activityi

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.1 Publication
Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.1 Publication

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421FMNBy similarity
Binding sitei66 – 661FMNBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 602FMNBy similarity
Nucleotide bindingi121 – 1222FMNBy similarity

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. pyridoxamine-phosphate oxidase activity Source: UniProtKB

GO - Biological processi

  1. pyridoxal 5'-phosphate salvage Source: UniProtKB
  2. pyridoxine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00190; UER00304.
UPA00190; UER00305.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine/pyridoxamine 5'-phosphate oxidase 2 (EC:1.4.3.5)
Short name:
AtPPOX1
Gene namesi
Name:PPOX2
Ordered Locus Names:At2g46580
ORF Names:F13A10.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G46580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Pyridoxine/pyridoxamine 5'-phosphate oxidase 2PRO_0000420550Add
BLAST

Proteomic databases

PaxDbiQ9ZPY1.
PRIDEiQ9ZPY1.

Expressioni

Gene expression databases

GenevestigatoriQ9ZPY1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT2G46580.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPY1.
SMRiQ9ZPY1. Positions 2-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 1614Poly-Leu

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5135.
HOGENOMiHOG000233130.
OMAiNYVEECA.
PhylomeDBiQ9ZPY1.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR000659. Pyridox_Oxase.
IPR024624. Pyridox_Oxase_Alr4036_FMN-bd.
IPR024015. Pyridox_Oxase_FMN-dep_Alr4036.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERiPTHR10851. PTHR10851. 1 hit.
PfamiPF12766. Pyridox_oxase_2. 1 hit.
[Graphical view]
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR04026. PPOX_FMN_cyano. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZPY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTHVAPWKQ LLFGAIEANS HLSHSSYVQL ATIGLNGRPS NRTVVFRGFE
60 70 80 90 100
ENSDRIQINT DLRSRKIEEL KHCPFSEMCW YFSDTWEQFR INGRIEVIDA
110 120 130 140 150
SNPDQTKLQQ REKAWFANSL RSRLIYVCPT PGSPCNSEQS SQQVKLDPSS
160 170 180 190
GPVPEYCLLL LEPEKVDYLN LKTNQRLFFS SMATGTGEKC WTSEKVNP
Length:198
Mass (Da):22,620
Last modified:June 1, 2002 - v2
Checksum:iEFDE8DA20D6A4376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006418 Genomic DNA. Translation: AAD20168.2.
CP002685 Genomic DNA. Translation: AEC10724.1.
AY086412 mRNA. Translation: AAM63414.1.
BT024917 mRNA. Translation: ABD94073.1.
PIRiF84904.
RefSeqiNP_566081.1. NM_130223.2.
UniGeneiAt.21431.

Genome annotation databases

EnsemblPlantsiAT2G46580.1; AT2G46580.1; AT2G46580.
GeneIDi819270.
KEGGiath:AT2G46580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006418 Genomic DNA. Translation: AAD20168.2 .
CP002685 Genomic DNA. Translation: AEC10724.1 .
AY086412 mRNA. Translation: AAM63414.1 .
BT024917 mRNA. Translation: ABD94073.1 .
PIRi F84904.
RefSeqi NP_566081.1. NM_130223.2.
UniGenei At.21431.

3D structure databases

ProteinModelPortali Q9ZPY1.
SMRi Q9ZPY1. Positions 2-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G46580.1-P.

Proteomic databases

PaxDbi Q9ZPY1.
PRIDEi Q9ZPY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G46580.1 ; AT2G46580.1 ; AT2G46580 .
GeneIDi 819270.
KEGGi ath:AT2G46580.

Organism-specific databases

TAIRi AT2G46580.

Phylogenomic databases

eggNOGi COG5135.
HOGENOMi HOG000233130.
OMAi NYVEECA.
PhylomeDBi Q9ZPY1.

Enzyme and pathway databases

UniPathwayi UPA00190 ; UER00304 .
UPA00190 ; UER00305 .

Miscellaneous databases

PROi Q9ZPY1.

Gene expression databases

Genevestigatori Q9ZPY1.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
InterProi IPR000659. Pyridox_Oxase.
IPR024624. Pyridox_Oxase_Alr4036_FMN-bd.
IPR024015. Pyridox_Oxase_FMN-dep_Alr4036.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
PANTHERi PTHR10851. PTHR10851. 1 hit.
Pfami PF12766. Pyridox_oxase_2. 1 hit.
[Graphical view ]
SUPFAMi SSF50475. SSF50475. 1 hit.
TIGRFAMsi TIGR04026. PPOX_FMN_cyano. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Kim C.J., Ecker J.R.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Identification of a second pyridoxine (pyridoxamine) 50-phosphate oxidase in Arabidopsis thaliana."
    Sang Y., Goertzen L.R., Tzou Y.-M., Locy R.D., Singh N.K.
    Acta Physiol. Plant. 33:559-566(2011)
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiPPOX2_ARATH
AccessioniPrimary (citable) accession number: Q9ZPY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3