Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial precursor

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Q9ZPX5 (DHSA2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial
EC=1.3.5.1

Alternative name(s):
Flavoprotein subunit 2 of complex II
Short name=FP

Gene names

Name:	SDH1-2
Ordered Locus Names:	At2g18450
ORF Names:	T30D6.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	FAD By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Subunit structure	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity. Ref.5
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Tissue specificity	Expressed at a low level. Ref.5
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, succinate to ubiquinone Traceable author statement Ref.5. Source: TAIR tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	mitochondrial respiratory chain complex II Inferred from sequence or structural similarity Ref.5. Source: TAIR
Molecular_function	disulfide oxidoreductase activity Inferred from electronic annotation. Source: EnsemblPlants/Gramene flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro succinate dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC succinate dehydrogenase activity Traceable author statement Ref.5. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 29

Mitochondrion Potential

Chain

30 – 632

603

Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial

PRO_0000247592

Regions

Nucleotide binding

54 – 59

FAD By similarity

Nucleotide binding

77 – 92

FAD By similarity

Nucleotide binding

444 – 445

FAD By similarity

Sites

Active site

327

Proton acceptor By similarity

Binding site

262

FAD By similarity

Binding site

283

Substrate By similarity

Binding site

295

Substrate By similarity

Binding site

394

Substrate By similarity

Binding site

428

FAD By similarity

Binding site

439

Substrate By similarity

Amino acid modifications

Modified residue

Tele-8alpha-FAD histidine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9ZPX5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: DEC34651679CEF88
Show »

FASTA

632

69,363

        10         20         30         40         50         60 
MWRCLRVASS SRRSESNGAF ITSQLSRFFS APPSAGDKSS YTIVDHTYDA VVVGAGGAGL 

        70         80         90        100        110        120 
RAAIGLSEHG FNTACITKLF PTRSHTVAAQ GGINAALGNM SVDDWRWHMY DTVKGSDWLG 

       130        140        150        160        170        180 
DQDAIQYMCR EAPKAVIELE NYGLPFSRTE DGKIYQRAFG GQSLEFGIGG QAYRCACAAD 

       190        200        210        220        230        240 
RTGHALLHTL YGQAMKHNTQ FFVEYFALDL IMNSDGTCQG VIALNMEDGT LHRFHAGSTI 

       250        260        270        280        290        300 
LATGGYGRAY FSATSAHTCT GDGNAMVARA GLPLQDLEFV QFHPTGIYGA GCLITEGARG 

       310        320        330        340        350        360 
EGGILRNSEG EKFMDRYAPT ARDLASRDVV SRSMTMEIRQ GRGAGPMKDY LYLYLNHLPP 

       370        380        390        400        410        420 
EVLKERLPGI SETAAIFAGV DVTREPIPVL PTVHYNMGGI PTNYHGEVIT LRGDDPDAVV 

       430        440        450        460        470        480 
PGLMAAGEAA CASVHGANRL GANSLLDIVV FGRACANRVA EIQKPGEKLK PLEKDAGEKS 

       490        500        510        520        530        540 
IEWLDRIRNS NGSLPTSKIR LNMQRVMQNN AAVFRTQETL EEGCDLIDKT WDSFGDVKVT 

       550        560        570        580        590        600 
DRSMIWNSDL IETMELENLL VNACITMHSA EARKESRGAH AREDFTKRDD ANWMKHTLGY 

       610        620        630 
WEEGNVKLEY RPVHMKTLDD EVDTFPPKPR VY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana." Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X. Plant Mol. Biol. 50:725-734(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, TISSUE SPECIFICITY.
[6]	"Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins." Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H. Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Strain: cv. Landsberg erecta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC006439 Genomic DNA. Translation: AAD15493.1. CP002685 Genomic DNA. Translation: AEC06769.1. AK119142 mRNA. Translation: BAC43712.1. BT005938 mRNA. Translation: AAO64873.1.
IPI	IPI00527700.
PIR	D84564.
RefSeq	NP_179435.1. NM_127401.2.
UniGene	At.39995.
3D structure databases
ProteinModelPortal	Q9ZPX5.
SMR	Q9ZPX5. Positions 39-632.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT2G18450.1-P.
Proteomic databases
PRIDE	Q9ZPX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G18450.1; AT2G18450.1; AT2G18450.
GeneID	816359.
KEGG	ath:AT2G18450.
Organism-specific databases
GeneFarm	2186. 174.
TAIR	At2g18450.
Phylogenomic databases
eggNOG	COG1053.
HOGENOM	HOG000160475.
InParanoid	Q9ZPX5.
KO	K00234.
OMA	YNTTSND.
PhylomeDB	Q9ZPX5.
ProtClustDB	PLN00128.
Enzyme and pathway databases
UniPathway	UPA00223; UER01006.
Gene expression databases
Genevestigator	Q9ZPX5.
GermOnline	AT2G18450. Arabidopsis thaliana.
Family and domain databases
Gene3D	1.20.58.100. 1 hit. 3.90.700.10. 1 hit.
InterPro	IPR003953. FAD_bind_dom. IPR003952. FRD_SDH_FAD_BS. IPR015939. Fum_Rdtase/Succ_DH_flav-like_C. IPR027477. Succ_DH/fumarate_Rdtase_cat. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_FrdA_Gneg. [Graphical view]
PANTHER	PTHR11632:SF5. PTHR11632:SF5. 1 hit.
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
SUPFAM	SSF56425. SSF56425. 1 hit. SSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMs	TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSA2_ARATH

Accession

Primary (citable) accession number: Q9ZPX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents