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Q9ZPX5

- SDHA2_ARATH

UniProt

Q9ZPX5 - SDHA2_ARATH

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Protein
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial
Gene
SDH1-2, At2g18450, T30D6.4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei262 – 2621FAD By similarity
Binding sitei283 – 2831Substrate By similarity
Binding sitei295 – 2951Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Binding sitei394 – 3941Substrate By similarity
Binding sitei428 – 4281FAD By similarity
Binding sitei439 – 4391Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 596FAD By similarity
Nucleotide bindingi77 – 9216FAD By similarity
Add
BLAST
Nucleotide bindingi444 – 4452FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. succinate dehydrogenase activity Source: TAIR

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit 2 of complex II
Short name:
FP
Gene namesi
Name:SDH1-2
Ordered Locus Names:At2g18450
ORF Names:T30D6.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G18450.

Subcellular locationi

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial respiratory chain complex II Source: TAIR
  2. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929Mitochondrion Reviewed prediction
Add
BLAST
Chaini30 – 632603Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial
PRO_0000247592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei85 – 851Tele-8alpha-FAD histidine By similarity

Proteomic databases

PRIDEiQ9ZPX5.

Expressioni

Tissue specificityi

Expressed at a low level.1 Publication

Gene expression databases

GenevestigatoriQ9ZPX5.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.1 Publication

Protein-protein interaction databases

STRINGi3702.AT2G18450.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPX5.
SMRiQ9ZPX5. Positions 39-632.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
HOGENOMiHOG000160475.
InParanoidiQ9ZPX5.
KOiK00234.
OMAiETIRWAE.
PhylomeDBiQ9ZPX5.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZPX5-1 [UniParc]FASTAAdd to Basket

« Hide

MWRCLRVASS SRRSESNGAF ITSQLSRFFS APPSAGDKSS YTIVDHTYDA    50
VVVGAGGAGL RAAIGLSEHG FNTACITKLF PTRSHTVAAQ GGINAALGNM 100
SVDDWRWHMY DTVKGSDWLG DQDAIQYMCR EAPKAVIELE NYGLPFSRTE 150
DGKIYQRAFG GQSLEFGIGG QAYRCACAAD RTGHALLHTL YGQAMKHNTQ 200
FFVEYFALDL IMNSDGTCQG VIALNMEDGT LHRFHAGSTI LATGGYGRAY 250
FSATSAHTCT GDGNAMVARA GLPLQDLEFV QFHPTGIYGA GCLITEGARG 300
EGGILRNSEG EKFMDRYAPT ARDLASRDVV SRSMTMEIRQ GRGAGPMKDY 350
LYLYLNHLPP EVLKERLPGI SETAAIFAGV DVTREPIPVL PTVHYNMGGI 400
PTNYHGEVIT LRGDDPDAVV PGLMAAGEAA CASVHGANRL GANSLLDIVV 450
FGRACANRVA EIQKPGEKLK PLEKDAGEKS IEWLDRIRNS NGSLPTSKIR 500
LNMQRVMQNN AAVFRTQETL EEGCDLIDKT WDSFGDVKVT DRSMIWNSDL 550
IETMELENLL VNACITMHSA EARKESRGAH AREDFTKRDD ANWMKHTLGY 600
WEEGNVKLEY RPVHMKTLDD EVDTFPPKPR VY 632
Length:632
Mass (Da):69,363
Last modified:May 1, 1999 - v1
Checksum:iDEC34651679CEF88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006439 Genomic DNA. Translation: AAD15493.1.
CP002685 Genomic DNA. Translation: AEC06769.1.
AK119142 mRNA. Translation: BAC43712.1.
BT005938 mRNA. Translation: AAO64873.1.
PIRiD84564.
RefSeqiNP_179435.1. NM_127401.2.
UniGeneiAt.39995.

Genome annotation databases

EnsemblPlantsiAT2G18450.1; AT2G18450.1; AT2G18450.
GeneIDi816359.
KEGGiath:AT2G18450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006439 Genomic DNA. Translation: AAD15493.1 .
CP002685 Genomic DNA. Translation: AEC06769.1 .
AK119142 mRNA. Translation: BAC43712.1 .
BT005938 mRNA. Translation: AAO64873.1 .
PIRi D84564.
RefSeqi NP_179435.1. NM_127401.2.
UniGenei At.39995.

3D structure databases

ProteinModelPortali Q9ZPX5.
SMRi Q9ZPX5. Positions 39-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G18450.1-P.

Proteomic databases

PRIDEi Q9ZPX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G18450.1 ; AT2G18450.1 ; AT2G18450 .
GeneIDi 816359.
KEGGi ath:AT2G18450.

Organism-specific databases

GeneFarmi 2186. 174.
TAIRi AT2G18450.

Phylogenomic databases

eggNOGi COG1053.
HOGENOMi HOG000160475.
InParanoidi Q9ZPX5.
KOi K00234.
OMAi ETIRWAE.
PhylomeDBi Q9ZPX5.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Gene expression databases

Genevestigatori Q9ZPX5.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana."
    Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X.
    Plant Mol. Biol. 50:725-734(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
  6. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiSDHA2_ARATH
AccessioniPrimary (citable) accession number: Q9ZPX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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