Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial

Gene

SDH1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial (SDH1-1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AXX17_At5g38380), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (AXX17_At3g29870), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial (SDH2-3), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2-2), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial (SDH2-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AXX17_At2g13790), Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (SDH1-2), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial (SDH2-2), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (AXX17_At5g66760)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei262FADBy similarity1
Binding sitei283SubstrateBy similarity1
Binding sitei295SubstrateBy similarity1
Active sitei327Proton acceptorBy similarity1
Binding sitei394SubstrateBy similarity1
Binding sitei428FADBy similarity1
Binding sitei439SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 59FADBy similarity6
Nucleotide bindingi77 – 92FADBy similarityAdd BLAST16
Nucleotide bindingi444 – 445FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit 2 of complex II
Short name:
FP
Gene namesi
Name:SDH1-2
Ordered Locus Names:At2g18450
ORF Names:T30D6.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18450
TAIRilocus:2062146 AT2G18450

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000024759230 – 632Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrialAdd BLAST603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PaxDbiQ9ZPX5
PRIDEiQ9ZPX5

Expressioni

Tissue specificityi

Expressed at a low level.1 Publication

Gene expression databases

ExpressionAtlasiQ9ZPX5 baseline and differential
GenevisibleiQ9ZPX5 AT

Interactioni

Subunit structurei

Component of complex II composed of eight subunits in plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.), as well as four subunits unknown in mitochondria from bacteria and heterotrophic eukaryotes.1 Publication

Protein-protein interaction databases

STRINGi3702.AT2G18450.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZPX5
SMRiQ9ZPX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
HOGENOMiHOG000160475
InParanoidiQ9ZPX5
KOiK00234
OMAiSRSMNME
OrthoDBiEOG093604YT
PhylomeDBiQ9ZPX5

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZPX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRCLRVASS SRRSESNGAF ITSQLSRFFS APPSAGDKSS YTIVDHTYDA
60 70 80 90 100
VVVGAGGAGL RAAIGLSEHG FNTACITKLF PTRSHTVAAQ GGINAALGNM
110 120 130 140 150
SVDDWRWHMY DTVKGSDWLG DQDAIQYMCR EAPKAVIELE NYGLPFSRTE
160 170 180 190 200
DGKIYQRAFG GQSLEFGIGG QAYRCACAAD RTGHALLHTL YGQAMKHNTQ
210 220 230 240 250
FFVEYFALDL IMNSDGTCQG VIALNMEDGT LHRFHAGSTI LATGGYGRAY
260 270 280 290 300
FSATSAHTCT GDGNAMVARA GLPLQDLEFV QFHPTGIYGA GCLITEGARG
310 320 330 340 350
EGGILRNSEG EKFMDRYAPT ARDLASRDVV SRSMTMEIRQ GRGAGPMKDY
360 370 380 390 400
LYLYLNHLPP EVLKERLPGI SETAAIFAGV DVTREPIPVL PTVHYNMGGI
410 420 430 440 450
PTNYHGEVIT LRGDDPDAVV PGLMAAGEAA CASVHGANRL GANSLLDIVV
460 470 480 490 500
FGRACANRVA EIQKPGEKLK PLEKDAGEKS IEWLDRIRNS NGSLPTSKIR
510 520 530 540 550
LNMQRVMQNN AAVFRTQETL EEGCDLIDKT WDSFGDVKVT DRSMIWNSDL
560 570 580 590 600
IETMELENLL VNACITMHSA EARKESRGAH AREDFTKRDD ANWMKHTLGY
610 620 630
WEEGNVKLEY RPVHMKTLDD EVDTFPPKPR VY
Length:632
Mass (Da):69,363
Last modified:May 1, 1999 - v1
Checksum:iDEC34651679CEF88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006439 Genomic DNA Translation: AAD15493.1
CP002685 Genomic DNA Translation: AEC06769.1
AK119142 mRNA Translation: BAC43712.1
BT005938 mRNA Translation: AAO64873.1
PIRiD84564
RefSeqiNP_179435.1, NM_127401.3
UniGeneiAt.39995

Genome annotation databases

EnsemblPlantsiAT2G18450.1; AT2G18450.1; AT2G18450
GeneIDi816359
GrameneiAT2G18450.1; AT2G18450.1; AT2G18450
KEGGiath:AT2G18450

Similar proteinsi

Entry informationi

Entry nameiSDHA2_ARATH
AccessioniPrimary (citable) accession number: Q9ZPX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health