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Q9ZPX5

- SDHA2_ARATH

UniProt

Q9ZPX5 - SDHA2_ARATH

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial

Gene

SDH1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei262 – 2621FADBy similarity
    Binding sitei283 – 2831SubstrateBy similarity
    Binding sitei295 – 2951SubstrateBy similarity
    Active sitei327 – 3271Proton acceptorBy similarity
    Binding sitei394 – 3941SubstrateBy similarity
    Binding sitei428 – 4281FADBy similarity
    Binding sitei439 – 4391SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 596FADBy similarity
    Nucleotide bindingi77 – 9216FADBy similarityAdd
    BLAST
    Nucleotide bindingi444 – 4452FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    3. succinate dehydrogenase activity Source: TAIR

    GO - Biological processi

    1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit 2 of complex II
    Short name:
    FP
    Gene namesi
    Name:SDH1-2
    Ordered Locus Names:At2g18450
    ORF Names:T30D6.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G18450.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex II Source: TAIR
    2. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
    BLAST
    Chaini30 – 632603Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrialPRO_0000247592Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei85 – 851Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PRIDEiQ9ZPX5.

    Expressioni

    Tissue specificityi

    Expressed at a low level.1 Publication

    Gene expression databases

    GenevestigatoriQ9ZPX5.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Protein-protein interaction databases

    STRINGi3702.AT2G18450.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZPX5.
    SMRiQ9ZPX5. Positions 39-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1053.
    HOGENOMiHOG000160475.
    InParanoidiQ9ZPX5.
    KOiK00234.
    OMAiETIRWAE.
    PhylomeDBiQ9ZPX5.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZPX5-1 [UniParc]FASTAAdd to Basket

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    MWRCLRVASS SRRSESNGAF ITSQLSRFFS APPSAGDKSS YTIVDHTYDA    50
    VVVGAGGAGL RAAIGLSEHG FNTACITKLF PTRSHTVAAQ GGINAALGNM 100
    SVDDWRWHMY DTVKGSDWLG DQDAIQYMCR EAPKAVIELE NYGLPFSRTE 150
    DGKIYQRAFG GQSLEFGIGG QAYRCACAAD RTGHALLHTL YGQAMKHNTQ 200
    FFVEYFALDL IMNSDGTCQG VIALNMEDGT LHRFHAGSTI LATGGYGRAY 250
    FSATSAHTCT GDGNAMVARA GLPLQDLEFV QFHPTGIYGA GCLITEGARG 300
    EGGILRNSEG EKFMDRYAPT ARDLASRDVV SRSMTMEIRQ GRGAGPMKDY 350
    LYLYLNHLPP EVLKERLPGI SETAAIFAGV DVTREPIPVL PTVHYNMGGI 400
    PTNYHGEVIT LRGDDPDAVV PGLMAAGEAA CASVHGANRL GANSLLDIVV 450
    FGRACANRVA EIQKPGEKLK PLEKDAGEKS IEWLDRIRNS NGSLPTSKIR 500
    LNMQRVMQNN AAVFRTQETL EEGCDLIDKT WDSFGDVKVT DRSMIWNSDL 550
    IETMELENLL VNACITMHSA EARKESRGAH AREDFTKRDD ANWMKHTLGY 600
    WEEGNVKLEY RPVHMKTLDD EVDTFPPKPR VY 632
    Length:632
    Mass (Da):69,363
    Last modified:May 1, 1999 - v1
    Checksum:iDEC34651679CEF88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006439 Genomic DNA. Translation: AAD15493.1.
    CP002685 Genomic DNA. Translation: AEC06769.1.
    AK119142 mRNA. Translation: BAC43712.1.
    BT005938 mRNA. Translation: AAO64873.1.
    PIRiD84564.
    RefSeqiNP_179435.1. NM_127401.2.
    UniGeneiAt.39995.

    Genome annotation databases

    EnsemblPlantsiAT2G18450.1; AT2G18450.1; AT2G18450.
    GeneIDi816359.
    KEGGiath:AT2G18450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006439 Genomic DNA. Translation: AAD15493.1 .
    CP002685 Genomic DNA. Translation: AEC06769.1 .
    AK119142 mRNA. Translation: BAC43712.1 .
    BT005938 mRNA. Translation: AAO64873.1 .
    PIRi D84564.
    RefSeqi NP_179435.1. NM_127401.2.
    UniGenei At.39995.

    3D structure databases

    ProteinModelPortali Q9ZPX5.
    SMRi Q9ZPX5. Positions 39-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G18450.1-P.

    Proteomic databases

    PRIDEi Q9ZPX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G18450.1 ; AT2G18450.1 ; AT2G18450 .
    GeneIDi 816359.
    KEGGi ath:AT2G18450.

    Organism-specific databases

    GeneFarmi 2186. 174.
    TAIRi AT2G18450.

    Phylogenomic databases

    eggNOGi COG1053.
    HOGENOMi HOG000160475.
    InParanoidi Q9ZPX5.
    KOi K00234.
    OMAi ETIRWAE.
    PhylomeDBi Q9ZPX5.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Gene expression databases

    Genevestigatori Q9ZPX5.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana."
      Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X.
      Plant Mol. Biol. 50:725-734(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY.
    6. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiSDHA2_ARATH
    AccessioniPrimary (citable) accession number: Q9ZPX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3