Reviewed,
UniProtKB/Swiss-Prot Q9ZPX5 (DHSA2_ARATH)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial EC=1.3.5.1 Alternative name(s): Flavoprotein subunit 2 of complex II Short name=FP | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 632 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. |
| Catalytic activity | Succinate + ubiquinone = fumarate + ubiquinol. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subunit structure | Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity. |
| Subcellular location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Ref.5 |
| Tissue specificity | Expressed at a low level. Ref.4 |
| Sequence similarities | Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 29 | 29 | Mitochondrion Potential | ||||||
| Chain | 30 – 632 | 603 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial | PRO_0000247592 | |||||
Regions | |||||||||
| Nucleotide binding | 77 – 92 | 16 | FAD By similarity | ||||||
Sites | |||||||||
| Active site | 327 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 283 | 1 | Substrate By similarity | ||||||
| Binding site | 295 | 1 | Substrate By similarity | ||||||
| Binding site | 394 | 1 | Substrate By similarity | ||||||
| Binding site | 439 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 85 | 1 | Tele-8alpha-FAD histidine By similarity | ||||||
Sequences
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References
| [1] | "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. Venter J.C.Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [3] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [4] | "The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana." Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X. Plant Mol. Biol. 50:725-734(2002) [PubMed: 12374303] [Abstract] Cited for: SUBUNIT, TISSUE SPECIFICITY. |
| [5] | "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins." Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H. Plant Cell 16:241-256(2004) [PubMed: 14671022] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| AC006439 Genomic DNA. Translation: AAD15493.1. AK119142 mRNA. Translation: BAC43712.1. BT005938 mRNA. Translation: AAO64873.1. | |
| IPI | IPI00527700. |
| PIR | D84564. |
| RefSeq | NP_179435.1. |
| UniGene | At.39995 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NEK based on UniProtKB P10444. |
| SMR | Q9ZPX5. Positions 39-632. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 816359. |
| GenomeReviews | Gene locus AT2G18450 in contig CT485783_GR. |
| KEGG | ath:AT2G18450. |
| NMPDR | fig|3702.1.peg.8841. |
Organism-specific databases | |
| GeneFarm | 2186. 174. |
| TAIR | At2g18450. |
Phylogenomic databases | |
| OMA | Q9ZPX5. ETMELEN. |
Enzyme and pathway databases | |
| BRENDA | 1.3.5.1. 302. |
Gene expression databases | |
| ArrayExpress | Q9ZPX5. |
| GermOnline | AT2G18450. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR003953. FAD_bind2_N. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR011281. Succ_DH_flav_su_fwd. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view] |
| Pfam | PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01816. sdhA_forward. 1 hit. TIGR01812. sdhA_frdA_Gneg. 1 hit. |
| PROSITE | PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHSA2_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9ZPX5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


