Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaphase-promoting complex subunit 10

Gene

APC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating the ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several other aspects of development. Involved in the control of endoreduplication.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: InterPro
  • cell division Source: UniProtKB-KW
  • cell proliferation Source: TAIR
  • mitotic nuclear division Source: UniProtKB-KW
  • negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation Source: GO_Central
  • negative regulation of DNA endoreduplication Source: TAIR
  • phloem or xylem histogenesis Source: TAIR
  • protein K11-linked ubiquitination Source: GO_Central
  • regulation of DNA endoreduplication Source: TAIR
  • regulation of mitotic metaphase/anaphase transition Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-179409. APC-Cdc20 mediated degradation of Nek2A.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 10
Short name:
APC10
Alternative name(s):
Cyclosome subunit 10
Gene namesi
Name:APC10
Ordered Locus Names:At2g18290
ORF Names:T30D6.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G18290.

Subcellular locationi

GO - Cellular componenti

  • anaphase-promoting complex Source: GO_Central
  • nuclear body Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Anaphase-promoting complex subunit 10PRO_0000174014Add
BLAST

Proteomic databases

PaxDbiQ9ZPW2.
PRIDEiQ9ZPW2.

PTM databases

iPTMnetiQ9ZPW2.

Expressioni

Gene expression databases

GenevisibleiQ9ZPW2. AT.

Interactioni

Subunit structurei

Component of the anaphase promoting complex/cyclosome (APC/C), which is composed of at least 10 subunits. Interacts with CDC20-1, CDC20-2, CDC27A and CDC27B.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC27AQ06AN93EBI-1749354,EBI-1749373
CDC27BQ8LGU63EBI-1749354,EBI-1668733

Protein-protein interaction databases

BioGridi1702. 22 interactions.
IntActiQ9ZPW2. 20 interactions.
STRINGi3702.AT2G18290.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPW2.
SMRiQ9ZPW2. Positions 27-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 192187DOCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the APC10 family.Curated
Contains 1 DOC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
HOGENOMiHOG000241616.
InParanoidiQ9ZPW2.
KOiK03357.
OMAiIRQIKVY.
OrthoDBiEOG09360OLG.
PhylomeDBiQ9ZPW2.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR016901. APC10.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
[Graphical view]
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiSM01337. APC10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZPW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATESSESEE EGKISGGNYK LIIDDDLREM GKNAAWSVSS CKPGNGVTTL
60 70 80 90 100
RDDNLETYWQ SDGLQPHLIN IQFQKKVKLQ LVVLYVDFKL DESYTPSKIS
110 120 130 140 150
IRAGDGFHNL KEIKSVELVK PTGWVCLSLS GTDPRETFVN TFMLQIAILS
160 170 180 190
NHLNGRDTHI RQIKVYGPRP NPIPHQPFQF TSMEFLTYST LR
Length:192
Mass (Da):21,750
Last modified:June 1, 2002 - v2
Checksum:i5ADBE0E8F7D12FFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121E → D in AAM64688 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006439 Genomic DNA. Translation: AAD15507.2.
CP002685 Genomic DNA. Translation: AEC06751.1.
AY087130 mRNA. Translation: AAM64688.1.
BT024912 mRNA. Translation: ABD94068.1.
AK229538 mRNA. Translation: BAF01391.1.
PIRiF84562.
RefSeqiNP_565433.1. NM_127387.3.
UniGeneiAt.21504.
At.63472.

Genome annotation databases

EnsemblPlantsiAT2G18290.1; AT2G18290.1; AT2G18290.
GeneIDi816345.
GrameneiAT2G18290.1; AT2G18290.1; AT2G18290.
KEGGiath:AT2G18290.

Cross-referencesi

Web resourcesi

Arabidopsis APC/C subunits

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006439 Genomic DNA. Translation: AAD15507.2.
CP002685 Genomic DNA. Translation: AEC06751.1.
AY087130 mRNA. Translation: AAM64688.1.
BT024912 mRNA. Translation: ABD94068.1.
AK229538 mRNA. Translation: BAF01391.1.
PIRiF84562.
RefSeqiNP_565433.1. NM_127387.3.
UniGeneiAt.21504.
At.63472.

3D structure databases

ProteinModelPortaliQ9ZPW2.
SMRiQ9ZPW2. Positions 27-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1702. 22 interactions.
IntActiQ9ZPW2. 20 interactions.
STRINGi3702.AT2G18290.1.

PTM databases

iPTMnetiQ9ZPW2.

Proteomic databases

PaxDbiQ9ZPW2.
PRIDEiQ9ZPW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18290.1; AT2G18290.1; AT2G18290.
GeneIDi816345.
GrameneiAT2G18290.1; AT2G18290.1; AT2G18290.
KEGGiath:AT2G18290.

Organism-specific databases

TAIRiAT2G18290.

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
HOGENOMiHOG000241616.
InParanoidiQ9ZPW2.
KOiK03357.
OMAiIRQIKVY.
OrthoDBiEOG09360OLG.
PhylomeDBiQ9ZPW2.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-ATH-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-ATH-179409. APC-Cdc20 mediated degradation of Nek2A.

Miscellaneous databases

PROiQ9ZPW2.

Gene expression databases

GenevisibleiQ9ZPW2. AT.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR016901. APC10.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
[Graphical view]
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiSM01337. APC10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPC10_ARATH
AccessioniPrimary (citable) accession number: Q9ZPW2
Secondary accession number(s): Q1WWJ4, Q8LBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.