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Q9ZPS4 (DCE3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate decarboxylase 3

Short name=GAD 3
EC=4.1.1.15
Gene names
Name:GAD3
Ordered Locus Names:At2g02000
ORF Names:F14H20.7
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis By similarity.

Catalytic activity

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Subunit structure

Homohexamer. Interacts with clamodulin By similarity.

Tissue specificity

Expressed at low levels in siliques. Ref.5

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Glutamate decarboxylase 3
PRO_0000416954

Amino acid modifications

Modified residue81Phosphoserine By similarity
Modified residue2771N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZPS4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1A47C0D14C6CD3B8

FASTA50056,507
        10         20         30         40         50         60 
MVLSKTASKS DDSIHSTFAS RYVRNSISRF EIPKNSIPKE AAYQIINDEL KFDGNPRLNL 

        70         80         90        100        110        120 
ASFVTTWMEP ECDKLMMESI NKNNVEMDQY PVTTDLQNRC VNMIARLFNA PLGDGEAAIG 

       130        140        150        160        170        180 
VGTVGSSEAV MLAGLAFKRQ WQNKRKALGL PYDRPNIVTG ANIQVCLEKF ARYFEVELKE 

       190        200        210        220        230        240 
VKLREGYYVM DPDKAVEMVD ENTICVVAIL GSTLTGEFED VKLLNDLLVE KNKKTGWDTP 

       250        260        270        280        290        300 
IHVDAASGGF IAPFLYPDLE WDFRLPLVKS INVSGHKYGL VYAGIGWVVW RTKTDLPDEL 

       310        320        330        340        350        360 
IFHINYLGAD QPTFTLNFSK GSSQVIAQYY QLIRLGFEGY RNVMDNCREN MMVLRQGLEK 

       370        380        390        400        410        420 
TGRFNIVSKE NGVPLVAFSL KDSSRHNEFE VAEMLRRFGW IVPAYTMPAD AQHVTVLRVV 

       430        440        450        460        470        480 
IREDFSRTLA ERLVADFEKV LHELDTLPAR VHAKMASGKV NGVKKTPEET QREVTAYWKK 

       490        500 
FVDTKTDKNG VPLVASITNQ 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Metabolism and functions of gamma-aminobutyric acid."
Shelp B.J., Bown A.W., McLean M.D.
Trends Plant Sci. 4:446-452(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana."
Miyashita Y., Good A.G.
Plant Cell Physiol. 49:92-102(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006532 Genomic DNA. Translation: AAD20093.1.
CP002685 Genomic DNA. Translation: AEC05531.1.
AK118125 mRNA. Translation: BAC42751.1.
PIRG84431.
RefSeqNP_178309.1. NM_126261.2.
UniGeneAt.41525.

3D structure databases

ProteinModelPortalQ9ZPS4.
SMRQ9ZPS4. Positions 13-474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT2G02000.1-P.

Proteomic databases

PaxDbQ9ZPS4.
PRIDEQ9ZPS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G02000.1; AT2G02000.1; AT2G02000.
GeneID814731.
KEGGath:AT2G02000.

Organism-specific databases

TAIRAT2G02000.

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000070228.
InParanoidQ9ZPS4.
KOK01580.
OMAVHAKMAS.
PhylomeDBQ9ZPS4.

Enzyme and pathway databases

BioCycARA:AT2G02000-MONOMER.

Gene expression databases

GenevestigatorQ9ZPS4.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCE3_ARATH
AccessionPrimary (citable) accession number: Q9ZPS4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names