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Protein

Glutamate decarboxylase 3

Gene

GAD3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).By similarity

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Decarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G02000-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 3 (EC:4.1.1.15)
Short name:
GAD 3
Gene namesi
Name:GAD3
Ordered Locus Names:At2g02000
ORF Names:F14H20.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G02000
TAIRilocus:2041120 AT2G02000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169541 – 500Glutamate decarboxylase 3Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei277N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZPS4
PRIDEiQ9ZPS4

PTM databases

iPTMnetiQ9ZPS4

Expressioni

Tissue specificityi

Expressed at low levels in siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ9ZPS4 differential
GenevisibleiQ9ZPS4 AT

Interactioni

Subunit structurei

Homohexamer. Interacts with clamodulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT2G02000.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZPS4
SMRiQ9ZPS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1383 Eukaryota
COG0076 LUCA
HOGENOMiHOG000070228
InParanoidiQ9ZPS4
KOiK01580
OrthoDBiEOG093607ZR
PhylomeDBiQ9ZPS4

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR010107 Glutamate_decarboxylase
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43321 PTHR43321, 1 hit
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01788 Glu-decarb-GAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZPS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSKTASKS DDSIHSTFAS RYVRNSISRF EIPKNSIPKE AAYQIINDEL
60 70 80 90 100
KFDGNPRLNL ASFVTTWMEP ECDKLMMESI NKNNVEMDQY PVTTDLQNRC
110 120 130 140 150
VNMIARLFNA PLGDGEAAIG VGTVGSSEAV MLAGLAFKRQ WQNKRKALGL
160 170 180 190 200
PYDRPNIVTG ANIQVCLEKF ARYFEVELKE VKLREGYYVM DPDKAVEMVD
210 220 230 240 250
ENTICVVAIL GSTLTGEFED VKLLNDLLVE KNKKTGWDTP IHVDAASGGF
260 270 280 290 300
IAPFLYPDLE WDFRLPLVKS INVSGHKYGL VYAGIGWVVW RTKTDLPDEL
310 320 330 340 350
IFHINYLGAD QPTFTLNFSK GSSQVIAQYY QLIRLGFEGY RNVMDNCREN
360 370 380 390 400
MMVLRQGLEK TGRFNIVSKE NGVPLVAFSL KDSSRHNEFE VAEMLRRFGW
410 420 430 440 450
IVPAYTMPAD AQHVTVLRVV IREDFSRTLA ERLVADFEKV LHELDTLPAR
460 470 480 490 500
VHAKMASGKV NGVKKTPEET QREVTAYWKK FVDTKTDKNG VPLVASITNQ
Length:500
Mass (Da):56,507
Last modified:May 1, 1999 - v1
Checksum:i1A47C0D14C6CD3B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006532 Genomic DNA Translation: AAD20093.1
CP002685 Genomic DNA Translation: AEC05531.1
AK118125 mRNA Translation: BAC42751.1
PIRiG84431
RefSeqiNP_178309.1, NM_126261.2
UniGeneiAt.41525

Genome annotation databases

EnsemblPlantsiAT2G02000.1; AT2G02000.1; AT2G02000
GeneIDi814731
GrameneiAT2G02000.1; AT2G02000.1; AT2G02000
KEGGiath:AT2G02000

Similar proteinsi

Entry informationi

Entry nameiDCE3_ARATH
AccessioniPrimary (citable) accession number: Q9ZPS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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