Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ZPS4

- DCE3_ARATH

UniProt

Q9ZPS4 - DCE3_ARATH

Protein

Glutamate decarboxylase 3

Gene

GAD3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis By similarity.By similarity

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Calmodulin-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciARA:AT2G02000-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylase 3 (EC:4.1.1.15)
    Short name:
    GAD 3
    Gene namesi
    Name:GAD3
    Ordered Locus Names:At2g02000
    ORF Names:F14H20.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G02000.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Glutamate decarboxylase 3PRO_0000416954Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81PhosphoserineBy similarity
    Modified residuei277 – 2771N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9ZPS4.
    PRIDEiQ9ZPS4.

    Expressioni

    Tissue specificityi

    Expressed at low levels in siliques.1 Publication

    Gene expression databases

    GenevestigatoriQ9ZPS4.

    Interactioni

    Subunit structurei

    Homohexamer. Interacts with clamodulin By similarity.By similarity

    Protein-protein interaction databases

    STRINGi3702.AT2G02000.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZPS4.
    SMRiQ9ZPS4. Positions 13-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    InParanoidiQ9ZPS4.
    KOiK01580.
    OMAiVHAKMAS.
    PhylomeDBiQ9ZPS4.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ZPS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSKTASKS DDSIHSTFAS RYVRNSISRF EIPKNSIPKE AAYQIINDEL    50
    KFDGNPRLNL ASFVTTWMEP ECDKLMMESI NKNNVEMDQY PVTTDLQNRC 100
    VNMIARLFNA PLGDGEAAIG VGTVGSSEAV MLAGLAFKRQ WQNKRKALGL 150
    PYDRPNIVTG ANIQVCLEKF ARYFEVELKE VKLREGYYVM DPDKAVEMVD 200
    ENTICVVAIL GSTLTGEFED VKLLNDLLVE KNKKTGWDTP IHVDAASGGF 250
    IAPFLYPDLE WDFRLPLVKS INVSGHKYGL VYAGIGWVVW RTKTDLPDEL 300
    IFHINYLGAD QPTFTLNFSK GSSQVIAQYY QLIRLGFEGY RNVMDNCREN 350
    MMVLRQGLEK TGRFNIVSKE NGVPLVAFSL KDSSRHNEFE VAEMLRRFGW 400
    IVPAYTMPAD AQHVTVLRVV IREDFSRTLA ERLVADFEKV LHELDTLPAR 450
    VHAKMASGKV NGVKKTPEET QREVTAYWKK FVDTKTDKNG VPLVASITNQ 500
    Length:500
    Mass (Da):56,507
    Last modified:May 1, 1999 - v1
    Checksum:i1A47C0D14C6CD3B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006532 Genomic DNA. Translation: AAD20093.1.
    CP002685 Genomic DNA. Translation: AEC05531.1.
    AK118125 mRNA. Translation: BAC42751.1.
    PIRiG84431.
    RefSeqiNP_178309.1. NM_126261.2.
    UniGeneiAt.41525.

    Genome annotation databases

    EnsemblPlantsiAT2G02000.1; AT2G02000.1; AT2G02000.
    GeneIDi814731.
    KEGGiath:AT2G02000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006532 Genomic DNA. Translation: AAD20093.1 .
    CP002685 Genomic DNA. Translation: AEC05531.1 .
    AK118125 mRNA. Translation: BAC42751.1 .
    PIRi G84431.
    RefSeqi NP_178309.1. NM_126261.2.
    UniGenei At.41525.

    3D structure databases

    ProteinModelPortali Q9ZPS4.
    SMRi Q9ZPS4. Positions 13-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G02000.1-P.

    Proteomic databases

    PaxDbi Q9ZPS4.
    PRIDEi Q9ZPS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G02000.1 ; AT2G02000.1 ; AT2G02000 .
    GeneIDi 814731.
    KEGGi ath:AT2G02000.

    Organism-specific databases

    TAIRi AT2G02000.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    InParanoidi Q9ZPS4.
    KOi K01580.
    OMAi VHAKMAS.
    PhylomeDBi Q9ZPS4.

    Enzyme and pathway databases

    BioCyci ARA:AT2G02000-MONOMER.

    Gene expression databases

    Genevestigatori Q9ZPS4.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Metabolism and functions of gamma-aminobutyric acid."
      Shelp B.J., Bown A.W., McLean M.D.
      Trends Plant Sci. 4:446-452(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana."
      Miyashita Y., Good A.G.
      Plant Cell Physiol. 49:92-102(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDCE3_ARATH
    AccessioniPrimary (citable) accession number: Q9ZPS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3