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Q9ZPS4

- DCE3_ARATH

UniProt

Q9ZPS4 - DCE3_ARATH

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Protein

Glutamate decarboxylase 3

Gene
GAD3, At2g02000, F14H20.7
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis By similarity.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate By similarity.

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Calmodulin-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G02000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 3 (EC:4.1.1.15)
Short name:
GAD 3
Gene namesi
Name:GAD3
Ordered Locus Names:At2g02000
ORF Names:F14H20.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G02000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Glutamate decarboxylase 3PRO_0000416954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine By similarity
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZPS4.
PRIDEiQ9ZPS4.

Expressioni

Tissue specificityi

Expressed at low levels in siliques.1 Publication

Gene expression databases

GenevestigatoriQ9ZPS4.

Interactioni

Subunit structurei

Homohexamer. Interacts with clamodulin By similarity.

Protein-protein interaction databases

STRINGi3702.AT2G02000.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPS4.
SMRiQ9ZPS4. Positions 13-474.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiQ9ZPS4.
KOiK01580.
OMAiVHAKMAS.
PhylomeDBiQ9ZPS4.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZPS4-1 [UniParc]FASTAAdd to Basket

« Hide

MVLSKTASKS DDSIHSTFAS RYVRNSISRF EIPKNSIPKE AAYQIINDEL    50
KFDGNPRLNL ASFVTTWMEP ECDKLMMESI NKNNVEMDQY PVTTDLQNRC 100
VNMIARLFNA PLGDGEAAIG VGTVGSSEAV MLAGLAFKRQ WQNKRKALGL 150
PYDRPNIVTG ANIQVCLEKF ARYFEVELKE VKLREGYYVM DPDKAVEMVD 200
ENTICVVAIL GSTLTGEFED VKLLNDLLVE KNKKTGWDTP IHVDAASGGF 250
IAPFLYPDLE WDFRLPLVKS INVSGHKYGL VYAGIGWVVW RTKTDLPDEL 300
IFHINYLGAD QPTFTLNFSK GSSQVIAQYY QLIRLGFEGY RNVMDNCREN 350
MMVLRQGLEK TGRFNIVSKE NGVPLVAFSL KDSSRHNEFE VAEMLRRFGW 400
IVPAYTMPAD AQHVTVLRVV IREDFSRTLA ERLVADFEKV LHELDTLPAR 450
VHAKMASGKV NGVKKTPEET QREVTAYWKK FVDTKTDKNG VPLVASITNQ 500
Length:500
Mass (Da):56,507
Last modified:May 1, 1999 - v1
Checksum:i1A47C0D14C6CD3B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006532 Genomic DNA. Translation: AAD20093.1.
CP002685 Genomic DNA. Translation: AEC05531.1.
AK118125 mRNA. Translation: BAC42751.1.
PIRiG84431.
RefSeqiNP_178309.1. NM_126261.2.
UniGeneiAt.41525.

Genome annotation databases

EnsemblPlantsiAT2G02000.1; AT2G02000.1; AT2G02000.
GeneIDi814731.
KEGGiath:AT2G02000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006532 Genomic DNA. Translation: AAD20093.1 .
CP002685 Genomic DNA. Translation: AEC05531.1 .
AK118125 mRNA. Translation: BAC42751.1 .
PIRi G84431.
RefSeqi NP_178309.1. NM_126261.2.
UniGenei At.41525.

3D structure databases

ProteinModelPortali Q9ZPS4.
SMRi Q9ZPS4. Positions 13-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G02000.1-P.

Proteomic databases

PaxDbi Q9ZPS4.
PRIDEi Q9ZPS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G02000.1 ; AT2G02000.1 ; AT2G02000 .
GeneIDi 814731.
KEGGi ath:AT2G02000.

Organism-specific databases

TAIRi AT2G02000.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
InParanoidi Q9ZPS4.
KOi K01580.
OMAi VHAKMAS.
PhylomeDBi Q9ZPS4.

Enzyme and pathway databases

BioCyci ARA:AT2G02000-MONOMER.

Gene expression databases

Genevestigatori Q9ZPS4.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Metabolism and functions of gamma-aminobutyric acid."
    Shelp B.J., Bown A.W., McLean M.D.
    Trends Plant Sci. 4:446-452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana."
    Miyashita Y., Good A.G.
    Plant Cell Physiol. 49:92-102(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDCE3_ARATH
AccessioniPrimary (citable) accession number: Q9ZPS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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