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Protein

Glutamate decarboxylase 4

Gene

GAD4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).By similarity

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Decarboxylase, Lyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 4 (EC:4.1.1.15)
Short name:
GAD 4
Gene namesi
Name:GAD4
Ordered Locus Names:At2g02010
ORF Names:F14H20.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G02010
TAIRilocus:2041130 AT2G02010

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169551 – 493Glutamate decarboxylase 4Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei277N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZPS3
PRIDEiQ9ZPS3

PTM databases

iPTMnetiQ9ZPS3

Expressioni

Tissue specificityi

Expressed in flowers and shoots. Detected at low levels in siliques, stems, leaves and roots.1 Publication

Inductioni

Up-regulated by salt treatment and hypoxia.2 Publications

Gene expression databases

ExpressionAtlasiQ9ZPS3 baseline and differential
GenevisibleiQ9ZPS3 AT

Interactioni

Subunit structurei

Homohexamer. Interacts with clamodulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT2G02010.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZPS3
SMRiQ9ZPS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1383 Eukaryota
COG0076 LUCA
HOGENOMiHOG000070228
InParanoidiQ9ZPS3
KOiK01580
OMAiNLREDYY
OrthoDBiEOG093607ZR
PhylomeDBiQ9ZPS3

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR010107 Glutamate_decarboxylase
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43321 PTHR43321, 1 hit
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01788 Glu-decarb-GAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZPS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSKTVSES DVSIHSTFAS RYVRNSLPRF EMPENSIPKE AAYQIINDEL
60 70 80 90 100
MLDGNPRLNL ASFVTTWMEP ECDKLMMESI NKNYVDMDEY PVTTELQNRC
110 120 130 140 150
VNMIARLFNA PLGDGEAAVG VGTVGSSEAI MLAGLAFKRQ WQNKRKAQGL
160 170 180 190 200
PYDKPNIVTG ANVQVCWEKF ARYFEVELKE VNLREDYYVM DPVKAVEMVD
210 220 230 240 250
ENTICVAAIL GSTLTGEFED VKLLNDLLVE KNKQTGWDTP IHVDAASGGF
260 270 280 290 300
IAPFLYPELE WDFRLPLVKS INVSGHKYGL VYAGIGWVVW RTKTDLPDEL
310 320 330 340 350
IFHINYLGAD QPTFTLNFSK GSSQVIAQYY QLIRLGFEGY RNVMDNCREN
360 370 380 390 400
MMVLRQGLEK TGRFKIVSKE NGVPLVAFSL KDSSRHNEFE VAHTLRRFGW
410 420 430 440 450
IVPAYTMPAD AQHVTVLRVV IREDFSRTLA ERLVADFEKV LHELDTLPAR
460 470 480 490
VHAKMANGKV NGVKKTPEET QREVTAYWKK LLETKKTNKN TIC
Length:493
Mass (Da):56,005
Last modified:May 1, 1999 - v1
Checksum:i36B3FC93F2978168
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006532 Genomic DNA Translation: AAD20099.1
CP002685 Genomic DNA Translation: AEC05532.1
AF361836 mRNA Translation: AAK32848.1
AY124860 mRNA Translation: AAM70569.1
PIRiH84431
RefSeqiNP_178310.1, NM_126262.2
UniGeneiAt.28718

Genome annotation databases

EnsemblPlantsiAT2G02010.1; AT2G02010.1; AT2G02010
GeneIDi814732
GrameneiAT2G02010.1; AT2G02010.1; AT2G02010
KEGGiath:AT2G02010

Similar proteinsi

Entry informationi

Entry nameiDCE4_ARATH
AccessioniPrimary (citable) accession number: Q9ZPS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health