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Q9ZPS3

- DCE4_ARATH

UniProt

Q9ZPS3 - DCE4_ARATH

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Protein

Glutamate decarboxylase 4

Gene

GAD4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).By similarity

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Calmodulin-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT2G02010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 4 (EC:4.1.1.15)
Short name:
GAD 4
Gene namesi
Name:GAD4
Ordered Locus Names:At2g02010
ORF Names:F14H20.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G02010.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Glutamate decarboxylase 4PRO_0000416955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine1 Publication
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ZPS3.
PRIDEiQ9ZPS3.

Expressioni

Tissue specificityi

Expressed in flowers and shoots. Detected at low levels in siliques, stems, leaves and roots.1 Publication

Inductioni

Up-regulated by salt treatment and hypoxia.2 Publications

Gene expression databases

GenevestigatoriQ9ZPS3.

Interactioni

Subunit structurei

Homohexamer. Interacts with clamodulin (By similarity).By similarity

Protein-protein interaction databases

STRINGi3702.AT2G02010.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9ZPS3.
SMRiQ9ZPS3. Positions 12-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
InParanoidiQ9ZPS3.
KOiK01580.
OMAiNAPKEMS.
PhylomeDBiQ9ZPS3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZPS3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSKTVSES DVSIHSTFAS RYVRNSLPRF EMPENSIPKE AAYQIINDEL
60 70 80 90 100
MLDGNPRLNL ASFVTTWMEP ECDKLMMESI NKNYVDMDEY PVTTELQNRC
110 120 130 140 150
VNMIARLFNA PLGDGEAAVG VGTVGSSEAI MLAGLAFKRQ WQNKRKAQGL
160 170 180 190 200
PYDKPNIVTG ANVQVCWEKF ARYFEVELKE VNLREDYYVM DPVKAVEMVD
210 220 230 240 250
ENTICVAAIL GSTLTGEFED VKLLNDLLVE KNKQTGWDTP IHVDAASGGF
260 270 280 290 300
IAPFLYPELE WDFRLPLVKS INVSGHKYGL VYAGIGWVVW RTKTDLPDEL
310 320 330 340 350
IFHINYLGAD QPTFTLNFSK GSSQVIAQYY QLIRLGFEGY RNVMDNCREN
360 370 380 390 400
MMVLRQGLEK TGRFKIVSKE NGVPLVAFSL KDSSRHNEFE VAHTLRRFGW
410 420 430 440 450
IVPAYTMPAD AQHVTVLRVV IREDFSRTLA ERLVADFEKV LHELDTLPAR
460 470 480 490
VHAKMANGKV NGVKKTPEET QREVTAYWKK LLETKKTNKN TIC
Length:493
Mass (Da):56,005
Last modified:May 1, 1999 - v1
Checksum:i36B3FC93F2978168
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006532 Genomic DNA. Translation: AAD20099.1.
CP002685 Genomic DNA. Translation: AEC05532.1.
AF361836 mRNA. Translation: AAK32848.1.
AY124860 mRNA. Translation: AAM70569.1.
PIRiH84431.
RefSeqiNP_178310.1. NM_126262.1.
UniGeneiAt.28718.

Genome annotation databases

EnsemblPlantsiAT2G02010.1; AT2G02010.1; AT2G02010.
GeneIDi814732.
KEGGiath:AT2G02010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006532 Genomic DNA. Translation: AAD20099.1 .
CP002685 Genomic DNA. Translation: AEC05532.1 .
AF361836 mRNA. Translation: AAK32848.1 .
AY124860 mRNA. Translation: AAM70569.1 .
PIRi H84431.
RefSeqi NP_178310.1. NM_126262.1.
UniGenei At.28718.

3D structure databases

ProteinModelPortali Q9ZPS3.
SMRi Q9ZPS3. Positions 12-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G02010.1-P.

Proteomic databases

PaxDbi Q9ZPS3.
PRIDEi Q9ZPS3.

Protocols and materials databases

DNASUi 814732.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G02010.1 ; AT2G02010.1 ; AT2G02010 .
GeneIDi 814732.
KEGGi ath:AT2G02010.

Organism-specific databases

TAIRi AT2G02010.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
InParanoidi Q9ZPS3.
KOi K01580.
OMAi NAPKEMS.
PhylomeDBi Q9ZPS3.

Enzyme and pathway databases

BioCyci ARA:AT2G02010-MONOMER.

Gene expression databases

Genevestigatori Q9ZPS3.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Metabolism and functions of gamma-aminobutyric acid."
    Shelp B.J., Bown A.W., McLean M.D.
    Trends Plant Sci. 4:446-452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Root.
  6. "Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana."
    Miyashita Y., Good A.G.
    Plant Cell Physiol. 49:92-102(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY HYPOXIA.
  7. "The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance."
    Renault H., Roussel V., El Amrani A., Arzel M., Renault D., Bouchereau A., Deleu C.
    BMC Plant Biol. 10:20-20(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY SALT.

Entry informationi

Entry nameiDCE4_ARATH
AccessioniPrimary (citable) accession number: Q9ZPS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3