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Q9ZPL5 (Q9ZPL5_TOBAC) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:metB EMBL AAD16143.1
OrganismNicotiana tabacum (Common tobacco) EMBL AAD16143.1
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Pyridoxal phosphate By similarity.

Sequence similarities

Belongs to the trans-sulfuration enzymes family. RuleBase RU004079

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site1631Important for catalytic activity
Site2361Important for catalytic activity
Site2611Important for catalytic activity

Amino acid modifications

Modified residue2611N6-(pyridoxal phosphate)lysine PDB 1I48 PDB 1QGN PDB 1I43

Sequences

Sequence LengthMass (Da)Tools
Q9ZPL5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D2936EDA41F02D44

FASTA44548,017
        10         20         30         40         50         60 
MAKAVDAAAA AAAAIAPVDT TVVNEDVALV ENETCNDQNV QFDSLPSMKY ASFLNSDGSV 

        70         80         90        100        110        120 
AIHAGERLGR GIVTDAITTP VVNTSAYFFN KTSELIDFKE KRRASFEYGR YGNPTTVVLE 

       130        140        150        160        170        180 
EKISALEGAE STLLMASGMC ASTVMLLALV PAGGHIVTTT DCYRKTRIFI ETILPKMGIT 

       190        200        210        220        230        240 
ATVIDPADVG ALELALNQKK VNLFFTESPT NPFLRCVDIE LVSKLCHEKG ALVCIDGTFA 

       250        260        270        280        290        300 
TPLNQKALAL GADLVLHSAT KFLGGHNDVL AGCISGPLKL VSEIRNLHHI LGGALNPNAA 

       310        320        330        340        350        360 
YLIIRGMKTL HLRVQQQNST ALRMAEILEA HPKVRHVYYP GLQSHPEHHI AKKQMTGFGG 

       370        380        390        400        410        420 
AVSFEVDGDL LTTAKFVDAL KIPYIAPSFG GCESIVDQPA IMSYWDLSQS DRAKYGIMDN 

       430        440 
LVRFSFGVED FDDLKADILQ ALDSI 

« Hide

References

[1]"Cloning, purification and characterization of cystathionine gamma-synthase from Nicotiana tabacum."
Clausen T., Laber B., Streber W.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity."
Steegborn C., Messerschmidt A., Laber B., Streber W., Huber R., Clausen T.
J. Mol. Biol. 290:983-996(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-261.
[3]"Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor."
Steegborn C., Laber B., Messerschmidt A., Huber R., Clausen T.
J. Mol. Biol. 311:789-801(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-261.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF097180 mRNA. Translation: AAD16143.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1I41X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
1I43X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
1I48X-ray3.25A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
1QGNX-ray2.90A/B/C/D/E/F/G/H1-445[»]
ProteinModelPortalQ9ZPL5.
SMRQ9ZPL5. Positions 49-445.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKQ9ZPL5.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11808. PTHR11808. 1 hit.
PfamPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFPIRSF001434. CGS. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9ZPL5.

Entry information

Entry nameQ9ZPL5_TOBAC
AccessionPrimary (citable) accession number: Q9ZPL5
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)