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Q9ZPL5

- Q9ZPL5_TOBAC

UniProt

Q9ZPL5 - Q9ZPL5_TOBAC

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Protein
Submitted name: Cystathionine gamma-synthase
Gene
metB
Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Pyridoxal phosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei163 – 1631Important for catalytic activityImported
Sitei236 – 2361Important for catalytic activityImported
Sitei261 – 2611Important for catalytic activityImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

SABIO-RKQ9ZPL5.

Names & Taxonomyi

Protein namesi
Submitted name:
Cystathionine gamma-synthaseImported
Gene namesi
Name:metBImported
OrganismiNicotiana tabacum (Common tobacco)Imported
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei261 – 2611N6-(pyridoxal phosphate)lysineImported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I41X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
1I43X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
1I48X-ray3.25A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
1QGNX-ray2.90A/B/C/D/E/F/G/H1-445[»]
ProteinModelPortaliQ9ZPL5.
SMRiQ9ZPL5. Positions 49-445.

Miscellaneous databases

EvolutionaryTraceiQ9ZPL5.

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZPL5-1 [UniParc]FASTAAdd to Basket

« Hide

MAKAVDAAAA AAAAIAPVDT TVVNEDVALV ENETCNDQNV QFDSLPSMKY    50
ASFLNSDGSV AIHAGERLGR GIVTDAITTP VVNTSAYFFN KTSELIDFKE 100
KRRASFEYGR YGNPTTVVLE EKISALEGAE STLLMASGMC ASTVMLLALV 150
PAGGHIVTTT DCYRKTRIFI ETILPKMGIT ATVIDPADVG ALELALNQKK 200
VNLFFTESPT NPFLRCVDIE LVSKLCHEKG ALVCIDGTFA TPLNQKALAL 250
GADLVLHSAT KFLGGHNDVL AGCISGPLKL VSEIRNLHHI LGGALNPNAA 300
YLIIRGMKTL HLRVQQQNST ALRMAEILEA HPKVRHVYYP GLQSHPEHHI 350
AKKQMTGFGG AVSFEVDGDL LTTAKFVDAL KIPYIAPSFG GCESIVDQPA 400
IMSYWDLSQS DRAKYGIMDN LVRFSFGVED FDDLKADILQ ALDSI 445
Length:445
Mass (Da):48,017
Last modified:May 1, 1999 - v1
Checksum:iD2936EDA41F02D44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097180 mRNA. Translation: AAD16143.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097180 mRNA. Translation: AAD16143.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I41 X-ray 3.20 A/B/C/D/E/F/G/H/I/J/K/L 1-445 [» ]
1I43 X-ray 3.10 A/B/C/D/E/F/G/H/I/J/K/L 1-445 [» ]
1I48 X-ray 3.25 A/B/C/D/E/F/G/H/I/J/K/L 1-445 [» ]
1QGN X-ray 2.90 A/B/C/D/E/F/G/H 1-445 [» ]
ProteinModelPortali Q9ZPL5.
SMRi Q9ZPL5. Positions 49-445.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK Q9ZPL5.

Miscellaneous databases

EvolutionaryTracei Q9ZPL5.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11808. PTHR11808. 1 hit.
Pfami PF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001434. CGS. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, purification and characterization of cystathionine gamma-synthase from Nicotiana tabacum."
    Clausen T., Laber B., Streber W.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity."
    Steegborn C., Messerschmidt A., Laber B., Streber W., Huber R., Clausen T.
    J. Mol. Biol. 290:983-996(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS), ACTIVE SITE, AND PYRIDOXAL PHOSPHATE AT LYS-261.
  3. "Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor."
    Steegborn C., Laber B., Messerschmidt A., Huber R., Clausen T.
    J. Mol. Biol. 311:789-801(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-261.

Entry informationi

Entry nameiQ9ZPL5_TOBAC
AccessioniPrimary (citable) accession number: Q9ZPL5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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