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Q9ZPL5

- Q9ZPL5_TOBAC

UniProt

Q9ZPL5 - Q9ZPL5_TOBAC

Protein
Submitted name:

Cystathionine gamma-synthase

Gene

metB

Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cofactori

    Pyridoxal phosphate.UniRule annotation
    Pyridoxal phosphate By similarity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei163 – 1631Important for catalytic activity
    Sitei236 – 2361Important for catalytic activity
    Binding sitei261 – 2611N6-(pyridoxalphosphate)lysine (covalent)Imported
    Sitei261 – 2611Important for catalytic activity

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    SABIO-RKQ9ZPL5.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cystathionine gamma-synthaseImported
    Gene namesi
    Name:metBImported
    OrganismiNicotiana tabacum (Common tobacco)Imported
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I41X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
    1I43X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
    1I48X-ray3.25A/B/C/D/E/F/G/H/I/J/K/L1-445[»]
    1QGNX-ray2.90A/B/C/D/E/F/G/H1-445[»]
    ProteinModelPortaliQ9ZPL5.
    SMRiQ9ZPL5. Positions 49-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ZPL5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the trans-sulfuration enzymes family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11808. PTHR11808. 1 hit.
    PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001434. CGS. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZPL5-1 [UniParc]FASTAAdd to Basket

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    MAKAVDAAAA AAAAIAPVDT TVVNEDVALV ENETCNDQNV QFDSLPSMKY    50
    ASFLNSDGSV AIHAGERLGR GIVTDAITTP VVNTSAYFFN KTSELIDFKE 100
    KRRASFEYGR YGNPTTVVLE EKISALEGAE STLLMASGMC ASTVMLLALV 150
    PAGGHIVTTT DCYRKTRIFI ETILPKMGIT ATVIDPADVG ALELALNQKK 200
    VNLFFTESPT NPFLRCVDIE LVSKLCHEKG ALVCIDGTFA TPLNQKALAL 250
    GADLVLHSAT KFLGGHNDVL AGCISGPLKL VSEIRNLHHI LGGALNPNAA 300
    YLIIRGMKTL HLRVQQQNST ALRMAEILEA HPKVRHVYYP GLQSHPEHHI 350
    AKKQMTGFGG AVSFEVDGDL LTTAKFVDAL KIPYIAPSFG GCESIVDQPA 400
    IMSYWDLSQS DRAKYGIMDN LVRFSFGVED FDDLKADILQ ALDSI 445
    Length:445
    Mass (Da):48,017
    Last modified:May 1, 1999 - v1
    Checksum:iD2936EDA41F02D44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097180 mRNA. Translation: AAD16143.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097180 mRNA. Translation: AAD16143.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I41 X-ray 3.20 A/B/C/D/E/F/G/H/I/J/K/L 1-445 [» ]
    1I43 X-ray 3.10 A/B/C/D/E/F/G/H/I/J/K/L 1-445 [» ]
    1I48 X-ray 3.25 A/B/C/D/E/F/G/H/I/J/K/L 1-445 [» ]
    1QGN X-ray 2.90 A/B/C/D/E/F/G/H 1-445 [» ]
    ProteinModelPortali Q9ZPL5.
    SMRi Q9ZPL5. Positions 49-445.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK Q9ZPL5.

    Miscellaneous databases

    EvolutionaryTracei Q9ZPL5.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11808. PTHR11808. 1 hit.
    Pfami PF01053. Cys_Met_Meta_PP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001434. CGS. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00868. CYS_MET_METAB_PP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, purification and characterization of cystathionine gamma-synthase from Nicotiana tabacum."
      Clausen T., Laber B., Streber W.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity."
      Steegborn C., Messerschmidt A., Laber B., Streber W., Huber R., Clausen T.
      J. Mol. Biol. 290:983-996(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH N6-(PYRIDOXALPHOSPHATE)LYSINE, ACTIVE SITE.
    3. "Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor."
      Steegborn C., Laber B., Messerschmidt A., Huber R., Clausen T.
      J. Mol. Biol. 311:789-801(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) IN COMPLEX WITH N6-(PYRIDOXALPHOSPHATE)LYSINE.

    Entry informationi

    Entry nameiQ9ZPL5_TOBAC
    AccessioniPrimary (citable) accession number: Q9ZPL5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3