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Q9ZPB7 (AL7A1_MALDO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 7 member A1

EC=1.2.1.3
Alternative name(s):
Antiquitin-1
Matured fruit 60 kDa protein
Short name=MF-60
OrganismMalus domestica (Apple) (Pyrus malus)
Taxonomic identifier3750 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in fruit development. Ref.1

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subunit structure

Homotetramer By similarity. UniProtKB P83402

Developmental stage

Expressed in developing fruit during the enlargement stage. Ref.1

Induction

By osmotic pressure changes Potential. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcellular aldehyde metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 508507Aldehyde dehydrogenase family 7 member A1
PRO_0000056497

Regions

Nucleotide binding244 – 2496NAD By similarity UniProtKB Q56694

Sites

Active site2661Proton acceptor By similarity UniProtKB Q56694
Active site3001Nucleophile By similarity UniProtKB Q56694
Site1651Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZPB7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FCE5487F10DEDABA

FASTA50854,244
        10         20         30         40         50         60 
MGFAKKEHEF LSAIGLAPEN PGGFINGKWK ASGPVISTVS PSNNQEIAKV TEVSMEEYEE 

        70         80         90        100        110        120 
GLRSCNDAAK TWKSLPAPKR GEIVRQIGDA LREKLQHLGK LVSLEMGKIL AEGIGEVQEV 

       130        140        150        160        170        180 
IYMCDFAVGL SRQLNGSIIP SERPDHMMFE VWNPLGIVGV ITAFNFPCAV LGWNACIALV 

       190        200        210        220        230        240 
CGNCVVWKGA PTTPLVTIAV TKLIAEVLEK NNLPAAIFTA FCGGAEIGEA IAKDTRIPLV 

       250        260        270        280        290        300 
SFTGSSKVGA KVQQIVTERF GKCLLELSGN NALIVMDDAD VGLAVRSIFF AAVGTAGQRC 

       310        320        330        340        350        360 
TTCRRLYLHE SIYQNVLDKL VGLYNQVKIG DPLEEGTLVG PVHTKASREN FEKGISTIKS 

       370        380        390        400        410        420 
QGGKILTGGS VIESDGNFVQ PTIVEIASNA SVVKEELFGP VLYVMKFKTL EEAIALNNSV 

       430        440        450        460        470        480 
PQGLSSSIFT SKPNTIFKWI GPHGSDCGIV NVNIPTNGAE IGGAFGGEKA TGGGREAGSD 

       490        500 
SWKQYMRRST CTINYGTELP LAQGINFG 

« Hide

References

[1]"Identification and cDNA cloning of a protein abundantly expressed during apple fruit development."
Yamada K., Mori H., Yamaki S.
Plant Cell Physiol. 40:198-204(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-31 AND 386-404, INDUCTION.
Strain: cv. Fuji.
Tissue: Fruit.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D88434 mRNA. Translation: BAA75633.1.

3D structure databases

ProteinModelPortalQ9ZPB7.
SMRQ9ZPB7. Positions 5-507.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL7A1_MALDO
AccessionPrimary (citable) accession number: Q9ZPB7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families