Aldehyde dehydrogenase family 7 member A1

Preferred order of sections

Names and origin

Protein names	Recommended name: Aldehyde dehydrogenase family 7 member A1 EC=1.2.1.3 Alternative name(s): Antiquitin-1 Matured fruit 60 kDa protein Short name=MF-60
Organism	Malus domestica (Apple) (Pyrus malus)
Taxonomic identifier	3750 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Amygdaloideae › Maleae › Malus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in fruit development. Ref.1
Catalytic activity	An aldehyde + NAD⁺ + H₂O = a carboxylate + NADH.
Subunit structure	Homotetramer By similarity. UniProtKB P83402
Developmental stage	Expressed in developing fruit during the enlargement stage. Ref.1
Induction	By osmotic pressure changes Potential. Ref.1
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	cellular aldehyde metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed Ref.1

Chain

2 – 508

507

Aldehyde dehydrogenase family 7 member A1

PRO_0000056497

Regions

Nucleotide binding

244 – 249

6

NAD By similarity UniProtKB Q56694

Sites

Active site

266

1

Proton acceptor By similarity UniProtKB Q56694

Active site

300

1

Nucleophile By similarity UniProtKB Q56694

Site

165

1

Transition state stabilizer By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9ZPB7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FCE5487F10DEDABA
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FASTA

508

54,244

        10         20         30         40         50         60 
MGFAKKEHEF LSAIGLAPEN PGGFINGKWK ASGPVISTVS PSNNQEIAKV TEVSMEEYEE 

        70         80         90        100        110        120 
GLRSCNDAAK TWKSLPAPKR GEIVRQIGDA LREKLQHLGK LVSLEMGKIL AEGIGEVQEV 

       130        140        150        160        170        180 
IYMCDFAVGL SRQLNGSIIP SERPDHMMFE VWNPLGIVGV ITAFNFPCAV LGWNACIALV 

       190        200        210        220        230        240 
CGNCVVWKGA PTTPLVTIAV TKLIAEVLEK NNLPAAIFTA FCGGAEIGEA IAKDTRIPLV 

       250        260        270        280        290        300 
SFTGSSKVGA KVQQIVTERF GKCLLELSGN NALIVMDDAD VGLAVRSIFF AAVGTAGQRC 

       310        320        330        340        350        360 
TTCRRLYLHE SIYQNVLDKL VGLYNQVKIG DPLEEGTLVG PVHTKASREN FEKGISTIKS 

       370        380        390        400        410        420 
QGGKILTGGS VIESDGNFVQ PTIVEIASNA SVVKEELFGP VLYVMKFKTL EEAIALNNSV 

       430        440        450        460        470        480 
PQGLSSSIFT SKPNTIFKWI GPHGSDCGIV NVNIPTNGAE IGGAFGGEKA TGGGREAGSD 

       490        500 
SWKQYMRRST CTINYGTELP LAQGINFG

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References

[1]

"Identification and cDNA cloning of a protein abundantly expressed during apple fruit development."
Yamada K., Mori H., Yamaki S.
Plant Cell Physiol. 40:198-204(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-31 AND 386-404, INDUCTION.
Strain: cv. Fuji.
Tissue: Fruit.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88434 mRNA. Translation: BAA75633.1.
3D structure databases
ProteinModelPortal	Q9ZPB7.
SMR	Q9ZPB7. Positions 5-507.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_MALDO

Accession

Primary (citable) accession number: Q9ZPB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families