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Q9ZPB7

- AL7A1_MALDO

UniProt

Q9ZPB7 - AL7A1_MALDO

Protein

Aldehyde dehydrogenase family 7 member A1

Gene
N/A
Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May play a role in fruit development.1 Publication

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei165 – 1651Transition state stabilizerBy similarity
    Active sitei266 – 2661Proton acceptorPROSITE-ProRule annotation
    Active sitei300 – 3001NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi244 – 2496NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3)
    Alternative name(s):
    Antiquitin-1
    Matured fruit 60 kDa protein
    Short name:
    MF-60
    OrganismiMalus domestica (Apple) (Pyrus malus)Imported
    Taxonomic identifieri3750 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 508507Aldehyde dehydrogenase family 7 member A1PRO_0000056497Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in developing fruit during the enlargement stage.1 Publication

    Inductioni

    By osmotic pressure changes.1 PublicationCurated

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZPB7.
    SMRiQ9ZPB7. Positions 5-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZPB7-1 [UniParc]FASTAAdd to Basket

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    MGFAKKEHEF LSAIGLAPEN PGGFINGKWK ASGPVISTVS PSNNQEIAKV    50
    TEVSMEEYEE GLRSCNDAAK TWKSLPAPKR GEIVRQIGDA LREKLQHLGK 100
    LVSLEMGKIL AEGIGEVQEV IYMCDFAVGL SRQLNGSIIP SERPDHMMFE 150
    VWNPLGIVGV ITAFNFPCAV LGWNACIALV CGNCVVWKGA PTTPLVTIAV 200
    TKLIAEVLEK NNLPAAIFTA FCGGAEIGEA IAKDTRIPLV SFTGSSKVGA 250
    KVQQIVTERF GKCLLELSGN NALIVMDDAD VGLAVRSIFF AAVGTAGQRC 300
    TTCRRLYLHE SIYQNVLDKL VGLYNQVKIG DPLEEGTLVG PVHTKASREN 350
    FEKGISTIKS QGGKILTGGS VIESDGNFVQ PTIVEIASNA SVVKEELFGP 400
    VLYVMKFKTL EEAIALNNSV PQGLSSSIFT SKPNTIFKWI GPHGSDCGIV 450
    NVNIPTNGAE IGGAFGGEKA TGGGREAGSD SWKQYMRRST CTINYGTELP 500
    LAQGINFG 508
    Length:508
    Mass (Da):54,244
    Last modified:January 23, 2007 - v3
    Checksum:iFCE5487F10DEDABA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88434 mRNA. Translation: BAA75633.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88434 mRNA. Translation: BAA75633.1 .

    3D structure databases

    ProteinModelPortali Q9ZPB7.
    SMRi Q9ZPB7. Positions 5-507.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cDNA cloning of a protein abundantly expressed during apple fruit development."
      Yamada K., Mori H., Yamaki S.
      Plant Cell Physiol. 40:198-204(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-31 AND 386-404, INDUCTION.
      Strain: cv. Fuji.
      Tissue: Fruit.

    Entry informationi

    Entry nameiAL7A1_MALDO
    AccessioniPrimary (citable) accession number: Q9ZPB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3