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Protein

Poly [ADP-ribose] polymerase 1

Gene

PARP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 91PARP-type 1PROSITE-ProRule annotationAdd BLAST84
Zinc fingeri114 – 194PARP-type 2PROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • DNA ligation involved in DNA repair Source: GO_Central
  • DNA repair Source: TAIR
  • lagging strand elongation Source: GO_Central
  • protein ADP-ribosylation Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to oxidative stress Source: TAIR

Keywordsi

Molecular functionDNA-binding, Glycosyltransferase, Transferase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-3108214 SUMOylation of DNA damage response and repair proteins
R-ATH-5685939 HDR through MMEJ (alt-NHEJ)
R-ATH-5696394 DNA Damage Recognition in GG-NER
R-ATH-5696395 Formation of Incision Complex in GG-NER
R-ATH-5696400 Dual Incision in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 1 (EC:2.4.2.30)
Short name:
PARP-1
Alternative name(s):
NAD(+) ADP-ribosyltransferase 1
Short name:
ADPRT-1
Poly[ADP-ribose] synthase 1
Gene namesi
Name:PARP1
Ordered Locus Names:At2g31320
ORF Names:F16D14.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G31320
TAIRilocus:2042511 AT2G31320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113311 – 983Poly [ADP-ribose] polymerase 1Add BLAST983

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ9ZP54
PRIDEiQ9ZP54

Expressioni

Inductioni

By ionising radiation (IR)-induced DNA damage.1 Publication

Gene expression databases

ExpressionAtlasiQ9ZP54 baseline and differential
GenevisibleiQ9ZP54 AT

Interactioni

Protein-protein interaction databases

BioGridi3038, 6 interactors
STRINGi3702.AT2G31320.1

Structurei

Secondary structure

1983
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 12Combined sources6
Beta strandi21 – 23Combined sources3
Beta strandi29 – 36Combined sources8
Beta strandi41 – 44Combined sources4
Beta strandi49 – 52Combined sources4
Helixi53 – 57Combined sources5
Beta strandi59 – 61Combined sources3
Helixi66 – 68Combined sources3
Turni71 – 74Combined sources4
Helixi77 – 87Combined sources11
Beta strandi91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V9XNMR-A5-105[»]
ProteinModelPortaliQ9ZP54
SMRiQ9ZP54
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZP54

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 484BRCTPROSITE-ProRule annotationAdd BLAST91
Domaini633 – 751PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST119
Domaini758 – 983PARP catalyticPROSITE-ProRule annotationAdd BLAST226

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 91PARP-type 1PROSITE-ProRule annotationAdd BLAST84
Zinc fingeri114 – 194PARP-type 2PROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
HOGENOMiHOG000030402
InParanoidiQ9ZP54
KOiK10798
OMAiWNHASCI
OrthoDBiEOG093601DX
PhylomeDBiQ9ZP54

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di1.20.142.10, 1 hit
2.20.140.10, 1 hit
2.20.25.630, 1 hit
3.30.1740.10, 2 hits
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR012982 PADR1
IPR038650 PADR1_dom_sf
IPR008288 PARP
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF08063 PADR1, 1 hit
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit
PF00645 zf-PARP, 2 hits
PIRSFiPIRSF000489 NAD_ADPRT, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM01335 PADR1, 1 hit
SM00773 WGR, 1 hit
SM01336 zf-PARP, 2 hits
SUPFAMiSSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit
PS50064 PARP_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9ZP54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPHKPWRA EYAKSSRSSC KTCKSVINKE NFRLGKLVQS THFDGIMPMW
60 70 80 90 100
NHASCILKKT KQIKSVDDVE GIESLRWEDQ QKIRKYVESG AGSNTSTSTG
110 120 130 140 150
TSTSSTANNA KLEYGIEVSQ TSRAGCRKCS EKILKGEVRI FSKPEGPGNK
160 170 180 190 200
GLMWHHAKCF LEMSSSTELE SLSGWRSIPD SDQEALLPLV KKALPAAKTE
210 220 230 240 250
TAEARQTNSR AGTKRKNDSV DNEKSKLAKS SFDMSTSGAL QPCSKEKEME
260 270 280 290 300
AQTKELWDLK DDLKKYVTSA ELREMLEVNE QSTRGSELDL RDKCADGMMF
310 320 330 340 350
GPLALCPMCS GHLSFSGGLY RCHGYISEWS KCSHSTLDPD RIKGKWKIPD
360 370 380 390 400
ETENQFLLKW NKSQKSVKPK RILRPVLSGE TSQGQGSKDA TDSSRSERLA
410 420 430 440 450
DLKVSIAGNT KERQPWKKRI EEAGAEFHAN VKKGTSCLVV CGLTDIRDAE
460 470 480 490 500
MRKARRMKVA IVREDYLVDC FKKQRKLPFD KYKIEDTSES LVTVKVKGRS
510 520 530 540 550
AVHEASGLQE HCHILEDGNS IYNTTLSMSD LSTGINSYYI LQIIQEDKGS
560 570 580 590 600
DCYVFRKWGR VGNEKIGGNK VEEMSKSDAV HEFKRLFLEK TGNTWESWEQ
610 620 630 640 650
KTNFQKQPGK FLPLDIDYGV NKQVAKKEPF QTSSNLAPSL IELMKMLFDV
660 670 680 690 700
ETYRSAMMEF EINMSEMPLG KLSKHNIQKG FEALTEIQRL LTESDPQPTM
710 720 730 740 750
KESLLVDASN RFFTMIPSIH PHIIRDEDDF KSKVKMLEAL QDIEIASRIV
760 770 780 790 800
GFDVDSTESL DDKYKKLHCD ISPLPHDSED YRLIEKYLNT THAPTHTEWS
810 820 830 840 850
LELEEVFALE REGEFDKYAP HREKLGNKML LWHGSRLTNF VGILNQGLRI
860 870 880 890 900
APPEAPATGY MFGKGIYFAD LVSKSAQYCY TCKKNPVGLM LLSEVALGEI
910 920 930 940 950
HELTKAKYMD KPPRGKHSTK GLGKKVPQDS EFAKWRGDVT VPCGKPVSSK
960 970 980
VKASELMYNE YIVYDTAQVK LQFLLKVRFK HKR
Length:983
Mass (Da):111,233
Last modified:December 1, 2001 - v2
Checksum:i468E12A8EF1B6F4F
GO

Sequence cautioni

The sequence AAD20677 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131705 mRNA Translation: CAA10482.1
AC006593 Genomic DNA Translation: AAD20677.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08527.1
AY091061 mRNA Translation: AAM13882.1
AY150460 mRNA Translation: AAN12901.1
PIRiC84719
T51353
RefSeqiNP_850165.1, NM_179834.2
UniGeneiAt.65741

Genome annotation databases

EnsemblPlantsiAT2G31320.1; AT2G31320.1; AT2G31320
GeneIDi817690
GrameneiAT2G31320.1; AT2G31320.1; AT2G31320
KEGGiath:AT2G31320

Similar proteinsi

Entry informationi

Entry nameiPARP1_ARATH
AccessioniPrimary (citable) accession number: Q9ZP54
Secondary accession number(s): Q9SJW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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