Reviewed,
UniProtKB/Swiss-Prot Q9ZP05 (MDHG1_ARATH)
Last modified
June 16, 2009.
Version 78.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Malate dehydrogenase, glyoxysomal EC=1.1.1.37 Alternative name(s): mbNAD-MDH | ||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||
| Taxonomic identifier | 3702 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 354 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Glyoxysome Potential. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 1 family. |
Ontologies
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: Q9ZP05-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 34 | 34 | Glyoxysome Potential | ||||||
| Chain | 35 – 354 | 320 | Malate dehydrogenase, glyoxysomal | PRO_0000018634 | |||||
Regions | |||||||||
| Nucleotide binding | 49 – 55 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 158 – 160 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 218 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 75 | 1 | NAD By similarity | ||||||
| Binding site | 122 | 1 | Substrate By similarity | ||||||
| Binding site | 128 | 1 | Substrate By similarity | ||||||
| Binding site | 135 | 1 | NAD By similarity | ||||||
| Binding site | 160 | 1 | Substrate By similarity | ||||||
| Binding site | 194 | 1 | Substrate By similarity | ||||||
| Binding site | 269 | 1 | NAD By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel, non-redox-regulated NAD-dependent malate dehydrogenase from chloroplasts of Arabidopsis thaliana L." Berkemeyer M., Scheibe R., Ocheretina O. J. Biol. Chem. 273:27927-27933(1998) [PubMed: 9774405] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. |
| [2] | "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones." Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H., Miyajima N., Tabata S. DNA Res. 6:183-195(1999) [PubMed: 10470850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [3] | "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana." Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. Fransz P.F.Nature 408:823-826(2000) [PubMed: 11130714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
Cross-references
Sequence databases | |
|---|---|
| AJ131206 mRNA. Translation: CAA10321.1. AB020752 Genomic DNA. Translation: BAB09521.1. AL353994 Genomic DNA. Translation: CAB89364.1. AF428373 mRNA. Translation: AAL16303.1. AY037252 mRNA. Translation: AAK59853.1. AY077653 mRNA. Translation: AAL76131.1. | |
| IPI | IPI00534849. |
| PIR | T49932. |
| RefSeq | NP_196528.1. |
| UniGene | At.40751 At.47611 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MLD based on UniProtKB P00346. |
| SMR | Q9ZP05. Positions 42-353. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9ZP05. |
| ProMEX | Q9ZP05. |
Genome annotation databases | |
| GeneID | 830825. |
| GenomeReviews | Gene locus AT5G09660 in contig BA000015_GR. |
| NMPDR | fig|3702.1.peg.23087. |
Organism-specific databases | |
| TAIR | At5g09660. |
Phylogenomic databases | |
| OMA | Q9ZP05. ENCRAKG. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.37. 302. |
Gene expression databases | |
| ArrayExpress | Q9ZP05. |
Family and domain databases | |
| InterPro | IPR001557. L-lactate/malate_DH. IPR001236. Lactate/malate_DH. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_NAD-dep_euk_g_bac. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11540:SF1. MDH_euk_g_bac. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| TIGRFAMs | TIGR01772. MDH_euk_gproteo. 1 hit. |
| PROSITE | PS00068. MDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDHG1_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9ZP05 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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