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Q9ZNY3

- CALR_EUGGR

UniProt

Q9ZNY3 - CALR_EUGGR

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Protein
Calreticulin
Gene
N/A
Organism
Euglena gracilis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Carbohydrate By similarity
Binding sitei109 – 1091Carbohydrate By similarity
Binding sitei125 – 1251Carbohydrate By similarity
Binding sitei132 – 1321Carbohydrate By similarity
Binding sitei314 – 3141Carbohydrate By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
OrganismiEuglena gracilis
Taxonomic identifieri3039 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaEuglenidaEuglenalesEuglenaceaeEuglena

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 401383Calreticulin
PRO_0000004190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 134 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ9ZNY3.
SMRiQ9ZNY3. Positions 202-275.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati187 – 198121-1
Add
BLAST
Repeati206 – 217121-2
Add
BLAST
Repeati223 – 234121-3
Add
BLAST
Repeati241 – 252121-4
Add
BLAST
Repeati256 – 266112-1
Add
BLAST
Repeati270 – 280112-2
Add
BLAST
Repeati284 – 294112-3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni187 – 252664 X approximate repeats
Add
BLAST
Regioni256 – 294393 X approximate repeats
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi398 – 4014Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi348 – 39750Asp/Glu/Lys-rich
Add
BLAST

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.
The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.
The zinc binding sites are localized to the N-domain By similarity.

Sequence similaritiesi

Belongs to the calreticulin family.

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZNY3-1 [UniParc]FASTAAdd to Basket

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MRKELWLGLL LSSQAVLSTI YYKETFEPDW ETRWTHSTAK SDYGKFKLTS    50
GKFYGDKAKD AGIQTSQDAK FYAISSPIAS SFSNEGKDLV LQFSVKHEQD 100
IDCGGGYLKL LPSVDAAKFT GDTPYHIMFG PDICGATKKI HFILTYKGKN 150
LLWKKEPRCE TDTLSHTYTA VIKADRTYEV LVDQVKKESG TLEEDWEILK 200
PKTIPDPEDK KPADWVDEPD MVDPEDKKPE DWDKEPAQIP DPDATQPDDW 250
DEEEDGKWEA PMISNPKYKG EWKAKKIPNP AYKGVWKPRD IPNPEYEADD 300
KVHIFDEIAA VGFDLWQVKS GTIFDNIIVT DSLAEAKAFY DQTNGATKDA 350
EKKAFDSAEA DKRKKEEDER KKQEEEEKKT AEEDEDDDDE EEEEDDKKDE 400
L 401
Length:401
Mass (Da):45,911
Last modified:May 1, 1999 - v1
Checksum:i056B074C16292674
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09816 mRNA. Translation: CAA70945.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09816 mRNA. Translation: CAA70945.1 .

3D structure databases

ProteinModelPortali Q9ZNY3.
SMRi Q9ZNY3. Positions 202-275.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002356. Calreticulin. 1 hit.
PRINTSi PR00626. CALRETICULIN.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence for conservation of a calcium homeostat component: purification characterization and cloning of calreticulin from Euglena gracilis."
    Navazzio L., Baldan B., Martin W., Mariani P.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCALR_EUGGR
AccessioniPrimary (citable) accession number: Q9ZNY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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