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Q9ZNY3 (CALR_EUGGR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calreticulin
OrganismEuglena gracilis
Taxonomic identifier3039 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaEuglenidaEuglenalesEuglenaceaeEuglena

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Domain

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.

The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.

The zinc binding sites are localized to the N-domain By similarity.

Sequence similarities

Belongs to the calreticulin family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Lectin
Metal-binding
Zinc
   Molecular functionChaperone
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 401383Calreticulin
PRO_0000004190

Regions

Repeat187 – 198121-1
Repeat206 – 217121-2
Repeat223 – 234121-3
Repeat241 – 252121-4
Repeat256 – 266112-1
Repeat270 – 280112-2
Repeat284 – 294112-3
Region187 – 252664 X approximate repeats
Region256 – 294393 X approximate repeats
Motif398 – 4014Prevents secretion from ER Potential
Compositional bias348 – 39750Asp/Glu/Lys-rich

Sites

Binding site1071Carbohydrate By similarity
Binding site1091Carbohydrate By similarity
Binding site1251Carbohydrate By similarity
Binding site1321Carbohydrate By similarity
Binding site3141Carbohydrate By similarity

Amino acid modifications

Disulfide bond103 ↔ 134 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZNY3 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 056B074C16292674

FASTA40145,911
        10         20         30         40         50         60 
MRKELWLGLL LSSQAVLSTI YYKETFEPDW ETRWTHSTAK SDYGKFKLTS GKFYGDKAKD 

        70         80         90        100        110        120 
AGIQTSQDAK FYAISSPIAS SFSNEGKDLV LQFSVKHEQD IDCGGGYLKL LPSVDAAKFT 

       130        140        150        160        170        180 
GDTPYHIMFG PDICGATKKI HFILTYKGKN LLWKKEPRCE TDTLSHTYTA VIKADRTYEV 

       190        200        210        220        230        240 
LVDQVKKESG TLEEDWEILK PKTIPDPEDK KPADWVDEPD MVDPEDKKPE DWDKEPAQIP 

       250        260        270        280        290        300 
DPDATQPDDW DEEEDGKWEA PMISNPKYKG EWKAKKIPNP AYKGVWKPRD IPNPEYEADD 

       310        320        330        340        350        360 
KVHIFDEIAA VGFDLWQVKS GTIFDNIIVT DSLAEAKAFY DQTNGATKDA EKKAFDSAEA 

       370        380        390        400 
DKRKKEEDER KKQEEEEKKT AEEDEDDDDE EEEEDDKKDE L 

« Hide

References

[1]"Evidence for conservation of a calcium homeostat component: purification characterization and cloning of calreticulin from Euglena gracilis."
Navazzio L., Baldan B., Martin W., Mariani P.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09816 mRNA. Translation: CAA70945.1.

3D structure databases

ProteinModelPortalQ9ZNY3.
SMRQ9ZNY3. Positions 202-275.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERPTHR11073. PTHR11073. 1 hit.
PfamPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFPIRSF002356. Calreticulin. 1 hit.
PRINTSPR00626. CALRETICULIN.
SUPFAMSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCALR_EUGGR
AccessionPrimary (citable) accession number: Q9ZNY3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families