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Q9ZNT7

- PHB2_ARATH

UniProt

Q9ZNT7 - PHB2_ARATH

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Protein

Prohibitin-2, mitochondrial

Gene

PHB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2, mitochondrial
Short name:
Atphb2
Gene namesi
Name:PHB2
Ordered Locus Names:At1g03860
ORF Names:F21M11.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G03860.

Subcellular locationi

Mitochondrion inner membrane 7 Publications; Single-pass type II membrane protein 7 Publications

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. chloroplast Source: TAIR
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrial respiratory chain complex I Source: TAIR
  5. mitochondrion Source: TAIR
  6. plastid Source: TAIR
  7. vacuolar membrane Source: TAIR
  8. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 286285Prohibitin-2, mitochondrialPRO_0000420597Add
BLAST

Proteomic databases

PaxDbiQ9ZNT7.
PRIDEiQ9ZNT7.

Expressioni

Tissue specificityi

Mostly expressed in proliferative tissues, including vasculature, shoot and root apical tissues.1 Publication

Gene expression databases

GenevestigatoriQ9ZNT7.

Interactioni

Subunit structurei

Component of a prohibitin multimeric complex in mitochondrial membranes.3 Publications

Protein-protein interaction databases

IntActiQ9ZNT7. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9ZNT7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1312Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini33 – 286254Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3219Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili186 – 21934Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0330.
HOGENOMiHOG000205692.
InParanoidiQ9ZNT7.
KOiK17081.
OMAiHRAVMFN.
PhylomeDBiQ9ZNT7.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ZNT7) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFNKVPNIP GAPALSALLK VSVIGGLGVY ALTNSLYNVD GGHRAVMFNR
60 70 80 90 100
LTGIKEKVYP EGTHFMVPWF ERPIIYDVRA RPYLVESTTG SHDLQMVKIG
110 120 130 140 150
LRVLTRPMGD RLPQIYRTLG ENYSERVLPS IIHETLKAVV AQYNASQLIT
160 170 180 190 200
QREAVSREIR KILTERASNF DIALDDVSIT TLTFGKEFTA AIEAKQVAAQ
210 220 230 240 250
EAERAKFIVE KAEQDRRSAV IRAQGEAKSA QLIGQAIANN QAFITLRKIE
260 270 280
AAREIAQTIA QSANKVYLSS NDLLLNLQEM NLEPKK
Length:286
Mass (Da):31,811
Last modified:May 1, 1999 - v1
Checksum:i89A48ECBA4F56DB8
GO
Isoform 2 (identifier: Q9ZNT7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-65: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:222
Mass (Da):25,028
Checksum:iD9F26BEC88A9CCFB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 6564Missing in isoform 2. CuratedVSP_044541Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66592 mRNA. Translation: AAD00156.1.
U89791 mRNA. Translation: AAD09244.1.
AC003027 Genomic DNA. Translation: AAD10682.1.
CP002684 Genomic DNA. Translation: AEE27624.1.
CP002684 Genomic DNA. Translation: AEE27625.1.
CP002684 Genomic DNA. Translation: AEE27626.1.
AF370317 mRNA. Translation: AAK44132.1.
AY063102 mRNA. Translation: AAL34276.1.
PIRiC86169.
RefSeqiNP_171882.1. NM_100266.2. [Q9ZNT7-1]
NP_973755.1. NM_202026.2.
NP_973756.1. NM_202027.1. [Q9ZNT7-1]
UniGeneiAt.24021.

Genome annotation databases

EnsemblPlantsiAT1G03860.1; AT1G03860.1; AT1G03860. [Q9ZNT7-1]
AT1G03860.3; AT1G03860.3; AT1G03860. [Q9ZNT7-1]
GeneIDi839228.
KEGGiath:AT1G03860.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66592 mRNA. Translation: AAD00156.1 .
U89791 mRNA. Translation: AAD09244.1 .
AC003027 Genomic DNA. Translation: AAD10682.1 .
CP002684 Genomic DNA. Translation: AEE27624.1 .
CP002684 Genomic DNA. Translation: AEE27625.1 .
CP002684 Genomic DNA. Translation: AEE27626.1 .
AF370317 mRNA. Translation: AAK44132.1 .
AY063102 mRNA. Translation: AAL34276.1 .
PIRi C86169.
RefSeqi NP_171882.1. NM_100266.2. [Q9ZNT7-1 ]
NP_973755.1. NM_202026.2.
NP_973756.1. NM_202027.1. [Q9ZNT7-1 ]
UniGenei At.24021.

3D structure databases

ProteinModelPortali Q9ZNT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ZNT7. 3 interactions.

Proteomic databases

PaxDbi Q9ZNT7.
PRIDEi Q9ZNT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G03860.1 ; AT1G03860.1 ; AT1G03860 . [Q9ZNT7-1 ]
AT1G03860.3 ; AT1G03860.3 ; AT1G03860 . [Q9ZNT7-1 ]
GeneIDi 839228.
KEGGi ath:AT1G03860.

Organism-specific databases

GeneFarmi 4382. 443.
TAIRi AT1G03860.

Phylogenomic databases

eggNOGi COG0330.
HOGENOMi HOG000205692.
InParanoidi Q9ZNT7.
KOi K17081.
OMAi HRAVMFN.
PhylomeDBi Q9ZNT7.

Gene expression databases

Genevestigatori Q9ZNT7.

Family and domain databases

InterProi IPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view ]
PANTHERi PTHR23222. PTHR23222. 1 hit.
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
PRINTSi PR00679. PROHIBITIN.
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Arabidopsis genes encoding prohibitin: importance for early development."
    Sun L., Goodman H.M.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  2. "Cloning of an Arabidopsis thaliana prohibitin-like cDNA by functional complementation of a sulfate transport yeast mutant."
    Hatzfeld Y., Logan H.M., Cathala N., Davidian J.-C.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  6. "Mitochondrial complex I from Arabidopsis and rice: orthologs of mammalian and fungal components coupled with plant-specific subunits."
    Heazlewood J.L., Howell K.A., Millar A.H.
    Biochim. Biophys. Acta 1604:159-169(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. "Mitochondrial type-I prohibitins of Arabidopsis thaliana are required for supporting proficient meristem development."
    Van Aken O., Pecenkova T., van de Cotte B., De Rycke R., Eeckhout D., Fromm H., De Jaeger G., Witters E., Beemster G.T.S., Inze D., Van Breusegem F.
    Plant J. 52:850-864(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: cv. Columbia.
  11. "Resolving and identifying protein components of plant mitochondrial respiratory complexes using three dimensions of gel electrophoresis."
    Meyer E.H., Taylor N.L., Millar A.H.
    J. Proteome Res. 7:786-794(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, SUBUNIT.
  12. "Defining the protein complex proteome of plant mitochondria."
    Klodmann J., Senkler M., Rode C., Braun H.-P.
    Plant Physiol. 157:587-598(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPHB2_ARATH
AccessioniPrimary (citable) accession number: Q9ZNT7
Secondary accession number(s): F4I2J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3