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Protein

Prohibitin-2, mitochondrial

Gene

PHB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2, mitochondrial
Short name:
Atphb2
Gene namesi
Name:PHB2
Ordered Locus Names:At1g03860
ORF Names:F21M11.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G03860
TAIRilocus:2024142 AT1G03860

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13Mitochondrial matrixSequence analysisAdd BLAST13
Transmembranei14 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini33 – 286Mitochondrial intermembraneSequence analysisAdd BLAST254

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004205971 – 286Prohibitin-2, mitochondrialAdd BLAST286

Proteomic databases

PaxDbiQ9ZNT7

Expressioni

Tissue specificityi

Mostly expressed in proliferative tissues, including vasculature, shoot and root apical tissues.1 Publication

Gene expression databases

ExpressionAtlasiQ9ZNT7 baseline and differential
GenevisibleiQ9ZNT7 AT

Interactioni

Subunit structurei

Component of a prohibitin multimeric complex in mitochondrial membranes.3 Publications

Protein-protein interaction databases

BioGridi24464, 3 interactors
IntActiQ9ZNT7, 3 interactors
STRINGi3702.AT1G03860.1

Structurei

3D structure databases

ProteinModelPortaliQ9ZNT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 219Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
HOGENOMiHOG000205692
InParanoidiQ9ZNT7
KOiK17081
OMAiHTISASN
OrthoDBiEOG09360JXQ
PhylomeDBiQ9ZNT7

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ZNT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFNKVPNIP GAPALSALLK VSVIGGLGVY ALTNSLYNVD GGHRAVMFNR
60 70 80 90 100
LTGIKEKVYP EGTHFMVPWF ERPIIYDVRA RPYLVESTTG SHDLQMVKIG
110 120 130 140 150
LRVLTRPMGD RLPQIYRTLG ENYSERVLPS IIHETLKAVV AQYNASQLIT
160 170 180 190 200
QREAVSREIR KILTERASNF DIALDDVSIT TLTFGKEFTA AIEAKQVAAQ
210 220 230 240 250
EAERAKFIVE KAEQDRRSAV IRAQGEAKSA QLIGQAIANN QAFITLRKIE
260 270 280
AAREIAQTIA QSANKVYLSS NDLLLNLQEM NLEPKK
Length:286
Mass (Da):31,811
Last modified:May 1, 1999 - v1
Checksum:i89A48ECBA4F56DB8
GO
Isoform 2 (identifier: Q9ZNT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:221
Mass (Da):24,897
Checksum:iB5C238E9B8E9C162
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445411 – 65Missing in isoform 2. CuratedAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66592 mRNA Translation: AAD00156.1
U89791 mRNA Translation: AAD09244.1
AC003027 Genomic DNA Translation: AAD10682.1
CP002684 Genomic DNA Translation: AEE27624.1
CP002684 Genomic DNA Translation: AEE27625.1
CP002684 Genomic DNA Translation: AEE27626.1
AF370317 mRNA Translation: AAK44132.1
AY063102 mRNA Translation: AAL34276.1
PIRiC86169
RefSeqiNP_171882.1, NM_100266.3 [Q9ZNT7-1]
NP_973755.1, NM_202026.2 [Q9ZNT7-2]
NP_973756.1, NM_202027.2 [Q9ZNT7-1]
UniGeneiAt.24021

Genome annotation databases

EnsemblPlantsiAT1G03860.1; AT1G03860.1; AT1G03860 [Q9ZNT7-1]
AT1G03860.2; AT1G03860.2; AT1G03860 [Q9ZNT7-2]
AT1G03860.3; AT1G03860.3; AT1G03860 [Q9ZNT7-1]
GeneIDi839228
GrameneiAT1G03860.1; AT1G03860.1; AT1G03860 [Q9ZNT7-1]
AT1G03860.2; AT1G03860.2; AT1G03860 [Q9ZNT7-2]
AT1G03860.3; AT1G03860.3; AT1G03860 [Q9ZNT7-1]
KEGGiath:AT1G03860

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPHB2_ARATH
AccessioniPrimary (citable) accession number: Q9ZNT7
Secondary accession number(s): F4I2J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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