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Q9ZNR6 (PDX12_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable pyridoxal biosynthesis protein PDX1.2

Short name=AtPDX1.2
Short name=AtPDX1;3
Gene names
Name:PDX12
Synonyms:A37, PDX1L2
Ordered Locus Names:At3g16050
ORF Names:MSL1.3
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the production of pyridoxal (vitamin B6) and indirect resistance to singlet oxygen-generating photosensitizers. Ref.6

Pathway

Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.

Subunit structure

Homodimer or heterodimer with PDX1.1 or PDX1.3. No interaction with PDX2.

Subcellular location

Cytoplasm Ref.6.

Tissue specificity

Expressed in callus tissues, flowers and roots. Weakly expressed in leaves and stems. Ref.1 Ref.7

Miscellaneous

Unlike PDX1.1 or PDX1.3, PDX1.2 is unable to interact with PDX2 and restore prototrophy in yeast snz1 mutants.

In plants, synthesis of vitamin B6 does not involve deoxyxylulose 5-phosphate but utilizes intermediates from the pentose phosphate pathway and from glycolysis.

Vitamin B6 is an essential quencher of singlet oxygen in plants, that can protect cellular membranes from lipid peroxidation.

Sequence similarities

Belongs to the pdxS/SNZ family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PDX13Q8L9405EBI-1545987,EBI-1545956

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Probable pyridoxal biosynthesis protein PDX1.2
PRO_0000109367

Sequences

Sequence LengthMass (Da)Tools
Q9ZNR6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D894BC393CBBBA6A

FASTA31433,836
        10         20         30         40         50         60 
MADQAMTDQD QGAVTLYSGT AITDAKKNHP FSVKVGLAQV LRGGAIVEVS SVNQAKLAES 

        70         80         90        100        110        120 
AGACSVIVSD PVRSRGGVRR MPDPVLIKEV KRAVSVPVMA RARVGHFVEA QILESLAVDY 

       130        140        150        160        170        180 
IDESEIISVA DDDHFINKHN FRSPFICGCR DTGEALRRIR EGAAMIRIQG DLTATGNIAE 

       190        200        210        220        230        240 
TVKNVRSLMG EVRVLNNMDD DEVFTFAKKI SAPYDLVAQT KQMGRVPVVQ FASGGITTPA 

       250        260        270        280        290        300 
DAALMMQLGC DGVFVGSEVF DGPDPFKKLR SIVQAVQHYN DPHVLAEMSS GLENAMESLN 

       310 
VRGDRIQDFG QGSV 

« Hide

References

« Hide 'large scale' references
[1]"T-DNA trapping of a cryptic promoter identifies an ortholog of highly conserved SNZ growth arrest response genes in Arabidopsis."
Oekresz L., Mathe C., Horvath E., Schell J., Koncz C., Szabados L.
Plant Sci. 138:217-228(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: cv. Columbia.
[2]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"Vitamin B6 biosynthesis in higher plants."
Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N., Fitzpatrick T.B.
Proc. Natl. Acad. Sci. U.S.A. 102:13687-13692(2005) [PubMed: 16157873] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis."
Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R., Hellmann H.
Plant Cell 18:1722-1735(2006) [PubMed: 16766694] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH PDX1.1 AND PDX1.3.
Strain: cv. C24.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF029980 mRNA. Translation: AAD01897.1.
AF029981 Genomic DNA. Translation: AAD01898.1.
AB012247 Genomic DNA. Translation: BAB02670.1.
CP002686 Genomic DNA. Translation: AEE75766.1.
BT003136 mRNA. Translation: AAO24568.1.
AK228092 mRNA. Translation: BAF00051.1.
IPIIPI00533004.
RefSeqNP_188226.1. NM_112475.3.
UniGeneAt.66514.
At.7601.

3D structure databases

ProteinModelPortalQ9ZNR6.
SMRQ9ZNR6. Positions 27-293.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9ZNR6. 4 interactions.
STRINGQ9ZNR6.

Proteomic databases

PRIDEQ9ZNR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G16050.1; AT3G16050.1; AT3G16050.
GeneID820850.
GenomeReviewsGene locus AT3G16050 in contig BA000014_GR.
KEGGath:AT3G16050.
NMPDRfig|3702.1.peg.13774.

Organism-specific databases

GeneFarm3240.
TAIRAt3g16050.

Phylogenomic databases

eggNOGKOG1606.
GeneTreeEPGT00050000010473.
HOGENOMHBG292342.
InParanoidQ9ZNR6.
OMARARVGHF.
PhylomeDBQ9ZNR6.
ProtClustDBCLSN2683112.

Gene expression databases

ArrayExpressQ9ZNR6.
GenevestigatorQ9ZNR6.
GermOnlineAT3G16050. Arabidopsis thaliana.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR001852. Snz1p/Sor1.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 2 hits.
KOK06215.
PANTHERPTHR22854:SF9. PTHR22854:SF9. 1 hit.
PfamPF01680. SOR_SNZ. 1 hit.
[Graphical view]
PIRSFPIRSF029271. Pdx1. 1 hit.
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
PROSITEPS01235. PDXS_SNZ_1. 1 hit.
PS51129. PDXS_SNZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDX12_ARATH
AccessionPrimary (citable) accession number: Q9ZNR6
Secondary accession number(s): Q0WS48
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 1, 1999
Last modified: December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families