Reviewed,
UniProtKB/Swiss-Prot Q9ZNR6 (PDX12_ARATH)
Last modified
February 9, 2010.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable pyridoxal biosynthesis protein PDX1.2 Short name=AtPDX1.2 Short name=AtPDX1;3 | ||||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 314 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in the production of pyridoxal (vitamin B6) and indirect resistance to singlet oxygen-generating photosensitizers. Ref.5 |
| Pathway | |
| Subunit structure | Homodimer or heterodimer with PDX1.1 or PDX1.3. No interaction with PDX2. |
| Subcellular location | |
| Tissue specificity | Expressed in callus tissues, flowers and roots. Weakly expressed in leaves and stems. Ref.1 Ref.6 |
| Miscellaneous | Unlike PDX1.1 or PDX1.3, PDX1.2 is unable to interact with PDX2 and restore prototrophy in yeast snz1 mutants. In plants, synthesis of vitamin B6 does not involve deoxyxylulose 5-phosphate but utilizes intermediates from the pentose phosphate pathway and from glycolysis. Vitamin B6 is an essential quencher of singlet oxygen in plants, that can protect cellular membranes from lipid peroxidation. |
| Sequence similarities | Belongs to the pdxS/SNZ family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyridoxine biosynthesis |
| Cellular component | Cytoplasm |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Ref.5 Inferred from direct assay. Source: TAIR |
| Molecular function | catalytic activity Inferred from electronic annotation. Source: InterPro identical protein binding Ref.6Inferred from physical interaction. Source: IntAct protein heterodimerization activity Ref.6Inferred from physical interaction. Source: TAIR |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 1 | EBI-1545987,EBI-1545987 | ||
| PDX11 | O80448 | 1 | EBI-1545987,EBI-1545972 | |
| PDX13 | Q8L940 | 1 | EBI-1545987,EBI-1545956 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 314 | 314 | Probable pyridoxal biosynthesis protein PDX1.2 | PRO_0000109367 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "T-DNA trapping of a cryptic promoter identifies an ortholog of highly conserved SNZ growth arrest response genes in Arabidopsis." Oekresz L., Mathe C., Horvath E., Schell J., Koncz C., Szabados L. Plant Sci. 138:217-228(1998) Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: cv. Columbia. |
| [2] | "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [3] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [4] | "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. Shinozaki K.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Vitamin B6 biosynthesis in higher plants." Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N., Fitzpatrick T.B. Proc. Natl. Acad. Sci. U.S.A. 102:13687-13692(2005) [PubMed: 16157873] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
| [6] | "Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis." Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A., Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R., Hellmann H. Plant Cell 18:1722-1735(2006) [PubMed: 16766694] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH PDX1.1 AND PDX1.3. Strain: cv. C24. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF029980 mRNA. Translation: AAD01897.1. AF029981 Genomic DNA. Translation: AAD01898.1. AB012247 Genomic DNA. Translation: BAB02670.1. BT003136 mRNA. Translation: AAO24568.1. AK228092 mRNA. Translation: BAF00051.1. |
| IPI | IPI00533004. |
| RefSeq | NP_188226.1. |
| UniGene | At.66514 At.7601 |
3D structure databases | |
| SMR | Q9ZNR6. Positions 28-296. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9ZNR6. 3 interactions. |
| STRING | Q9ZNR6. |
Proteomic databases | |
| PRIDE | Q9ZNR6. |
Genome annotation databases | |
| GeneID | 820850. |
| GenomeReviews | Gene locus AT3G16050 in contig BA000014_GR. |
| KEGG | ath:AT3G16050. |
| NMPDR | fig|3702.1.peg.13774. |
Organism-specific databases | |
| GeneFarm | 3240. |
| TAIR | At3g16050. |
Phylogenomic databases | |
| eggNOG | KOG1606. |
| HOGENOM | HBG292342. |
| InParanoid | Q9ZNR6. |
| OMA | ARARVGH. |
| PhylomeDB | Q9ZNR6. |
Gene expression databases | |
| ArrayExpress | Q9ZNR6. |
| Genevestigator | Q9ZNR6. |
| GermOnline | AT3G16050. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR011060. RibuloseP-bd_barrel. IPR001852. Snz1p/Sor1. [Graphical view] |
| Pfam | PF01680. SOR_SNZ. 1 hit. [Graphical view] |
| PIRSF | PIRSF029271. Pdx1. 1 hit. |
| PROSITE | PS01235. PDXS_SNZ_1. 1 hit. PS51129. PDXS_SNZ_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PDX12_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9ZNR6 Secondary accession number(s): Q0WS48 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


