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Protein

Cytochrome P450 78A6

Gene

CYP78A6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays role in seed and fruit development. Functions probably in association with CYP78A9 in the regulation of seed growth. Acts maternally to promote seed growth.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi474 – 4741Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • regulation of growth Source: UniProtKB-KW
  • secondary metabolite biosynthetic process Source: GO_Central
  • seed development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G46660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 78A6 (EC:1.14.-.-)
Alternative name(s):
Protein ENHANCER OF DA1-1
Gene namesi
Name:CYP78A6
Synonyms:EOD3
Ordered Locus Names:At2g46660
ORF Names:T3A4.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G46660.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced seed size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cytochrome P450 78A6PRO_0000422988Add
BLAST

Proteomic databases

PaxDbiQ9ZNR0.
PRIDEiQ9ZNR0.

Expressioni

Tissue specificityi

Expressed in leaves, sepals, petals, stamens, carpels and developing ovules.1 Publication

Gene expression databases

GenevisibleiQ9ZNR0. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G46660.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZNR0.
SMRiQ9ZNR0. Positions 72-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000218628.
InParanoidiQ9ZNR0.
OMAiHEFEWGP.
OrthoDBiEOG093606PQ.
PhylomeDBiQ9ZNR0.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZNR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLESSLI FALLSKCSVL SQTNLAFSLL AVTIIWLAIS LFLWTYPGGP
60 70 80 90 100
AWGKYLFGRL ISGSYKTGNV IPGPKGFPLV GSMSLMSSTL AHRRIADAAE
110 120 130 140 150
KFGAKRLMAF SLGETRVIVT CNPDVAKEIL NSPVFADRPV KESAYSLMFN
160 170 180 190 200
RAIGFAPHGV YWRTLRRIAS NHLFSTKQIR RAETQRRVIS SQMVEFLEKQ
210 220 230 240 250
SSNEPCFVRE LLKTASLNNM MCSVFGQEYE LEKNHVELRE MVEEGYDLLG
260 270 280 290 300
TLNWTDHLPW LSEFDPQRLR SRCSTLVPKV NRFVSRIISE HRNQTGDLPR
310 320 330 340 350
DFVDVLLSLH GSDKLSDPDI IAVLWEMIFR GTDTVAVLIE WILARMVLHP
360 370 380 390 400
DMQSTVQNEL DQVVGKSRAL DESDLASLPY LTAVVKEVLR LHPPGPLLSW
410 420 430 440 450
ARLAITDTIV DGRLVPAGTT AMVNMWAVSH DPHVWVDPLE FKPERFVAKE
460 470 480 490 500
GEVEFSVLGS DLRLAPFGSG RRICPGKNLG FTTVMFWTAM MLHEFEWGPS
510 520 530
DGNGVDLSEK LRLSCEMANP LPAKLRRRRS
Length:530
Mass (Da):59,565
Last modified:May 1, 1999 - v1
Checksum:i87CDA9DFC395D62F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005819 Genomic DNA. Translation: AAC69923.1.
AC006418 Genomic DNA. Translation: AAM15240.1.
CP002685 Genomic DNA. Translation: AEC10736.1.
AK226763 mRNA. Translation: BAE98862.1.
PIRiF84905.
RefSeqiNP_182189.1. NM_130231.3.
UniGeneiAt.36480.

Genome annotation databases

EnsemblPlantsiAT2G46660.1; AT2G46660.1; AT2G46660.
GeneIDi819278.
GrameneiAT2G46660.1; AT2G46660.1; AT2G46660.
KEGGiath:AT2G46660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005819 Genomic DNA. Translation: AAC69923.1.
AC006418 Genomic DNA. Translation: AAM15240.1.
CP002685 Genomic DNA. Translation: AEC10736.1.
AK226763 mRNA. Translation: BAE98862.1.
PIRiF84905.
RefSeqiNP_182189.1. NM_130231.3.
UniGeneiAt.36480.

3D structure databases

ProteinModelPortaliQ9ZNR0.
SMRiQ9ZNR0. Positions 72-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G46660.1.

Proteomic databases

PaxDbiQ9ZNR0.
PRIDEiQ9ZNR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G46660.1; AT2G46660.1; AT2G46660.
GeneIDi819278.
GrameneiAT2G46660.1; AT2G46660.1; AT2G46660.
KEGGiath:AT2G46660.

Organism-specific databases

TAIRiAT2G46660.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000218628.
InParanoidiQ9ZNR0.
OMAiHEFEWGP.
OrthoDBiEOG093606PQ.
PhylomeDBiQ9ZNR0.

Enzyme and pathway databases

BioCyciARA:AT2G46660-MONOMER.

Miscellaneous databases

PROiQ9ZNR0.

Gene expression databases

GenevisibleiQ9ZNR0. AT.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC78A6_ARATH
AccessioniPrimary (citable) accession number: Q9ZNR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The gain of function mutants eod3-1D (T-DNA tagging) show increased size of leaves, flowers and seeds, but defects in reproductive development.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.