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Protein

Cytochrome P450 78A6

Gene

CYP78A6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays role in seed and fruit development. Functions probably in association with CYP78A9 in the regulation of seed growth. Acts maternally to promote seed growth.1 Publication

Miscellaneous

The gain of function mutants eod3-1D (T-DNA tagging) show increased size of leaves, flowers and seeds, but defects in reproductive development.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi474Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • regulation of growth Source: UniProtKB-KW
  • secondary metabolite biosynthetic process Source: GO_Central
  • seed development Source: TAIR

Keywordsi

Molecular functionDevelopmental protein, Monooxygenase, Oxidoreductase
Biological processGrowth regulation
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G46660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 78A6 (EC:1.14.-.-)
Alternative name(s):
Protein ENHANCER OF DA1-1
Gene namesi
Name:CYP78A6
Synonyms:EOD3
Ordered Locus Names:At2g46660
ORF Names:T3A4.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G46660.
TAIRilocus:2039954. AT2G46660.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced seed size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004229881 – 530Cytochrome P450 78A6Add BLAST530

Proteomic databases

PaxDbiQ9ZNR0.

Expressioni

Tissue specificityi

Expressed in leaves, sepals, petals, stamens, carpels and developing ovules.1 Publication

Gene expression databases

GenevisibleiQ9ZNR0. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G46660.1.

Structurei

3D structure databases

ProteinModelPortaliQ9ZNR0.
SMRiQ9ZNR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000218628.
InParanoidiQ9ZNR0.
OMAiRSCMGYK.
OrthoDBiEOG093606PQ.
PhylomeDBiQ9ZNR0.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZNR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLESSLI FALLSKCSVL SQTNLAFSLL AVTIIWLAIS LFLWTYPGGP
60 70 80 90 100
AWGKYLFGRL ISGSYKTGNV IPGPKGFPLV GSMSLMSSTL AHRRIADAAE
110 120 130 140 150
KFGAKRLMAF SLGETRVIVT CNPDVAKEIL NSPVFADRPV KESAYSLMFN
160 170 180 190 200
RAIGFAPHGV YWRTLRRIAS NHLFSTKQIR RAETQRRVIS SQMVEFLEKQ
210 220 230 240 250
SSNEPCFVRE LLKTASLNNM MCSVFGQEYE LEKNHVELRE MVEEGYDLLG
260 270 280 290 300
TLNWTDHLPW LSEFDPQRLR SRCSTLVPKV NRFVSRIISE HRNQTGDLPR
310 320 330 340 350
DFVDVLLSLH GSDKLSDPDI IAVLWEMIFR GTDTVAVLIE WILARMVLHP
360 370 380 390 400
DMQSTVQNEL DQVVGKSRAL DESDLASLPY LTAVVKEVLR LHPPGPLLSW
410 420 430 440 450
ARLAITDTIV DGRLVPAGTT AMVNMWAVSH DPHVWVDPLE FKPERFVAKE
460 470 480 490 500
GEVEFSVLGS DLRLAPFGSG RRICPGKNLG FTTVMFWTAM MLHEFEWGPS
510 520 530
DGNGVDLSEK LRLSCEMANP LPAKLRRRRS
Length:530
Mass (Da):59,565
Last modified:May 1, 1999 - v1
Checksum:i87CDA9DFC395D62F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005819 Genomic DNA. Translation: AAC69923.1.
AC006418 Genomic DNA. Translation: AAM15240.1.
CP002685 Genomic DNA. Translation: AEC10736.1.
AK226763 mRNA. Translation: BAE98862.1.
PIRiF84905.
RefSeqiNP_182189.1. NM_130231.4.
UniGeneiAt.36480.

Genome annotation databases

EnsemblPlantsiAT2G46660.1; AT2G46660.1; AT2G46660.
GeneIDi819278.
GrameneiAT2G46660.1; AT2G46660.1; AT2G46660.
KEGGiath:AT2G46660.

Similar proteinsi

Entry informationi

Entry nameiC78A6_ARATH
AccessioniPrimary (citable) accession number: Q9ZNR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families