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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Clostridium histolyticum
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
OrganismiClostridium histolyticum
Taxonomic identifieri1498 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Peptide methionine sulfoxide reductase MsrBPRO_0000140268Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9ZNJ9.
SMRiQ9ZNJ9. Positions 15-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZNJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHKKEKEYK KLDTEKLKEN LTELQYNVTQ RNATEKPFLN KYDKHFEDGI
60 70 80 90 100
YVDIVSGEPL FLSIDKFNSG CGWPAFSKPI SRKYIKERAD FSHGMSRIEV
110 120 130 140 150
RSKNADSHLG HVFNDGPIEN GGMRYCINSA SLKFIAKDKL KEEGYEEFLP

LFEKDKQEL
Length:159
Mass (Da):18,531
Last modified:May 1, 1999 - v1
Checksum:iFF50ACEEA1871231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014075 Genomic DNA. Translation: BAA34541.1.
PIRiT44354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014075 Genomic DNA. Translation: BAA34541.1.
PIRiT44354.

3D structure databases

ProteinModelPortaliQ9ZNJ9.
SMRiQ9ZNJ9. Positions 15-154.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Gene duplication and multiplicity of collagenases in Clostridium histolyticum."
    Matsushita O., Jung C.-M., Katayama S., Minami J., Takahashi Y., Okabe A.
    J. Bacteriol. 181:923-933(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 19401 / DSM 2158 / JCM 1403 / NCIB 503.

Entry informationi

Entry nameiMSRB_CLOHI
AccessioniPrimary (citable) accession number: Q9ZNJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.