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Protein

Na(+)/H(+) antiporter subunit A1

Gene

mnhA1

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mnh complex is a Na+Li+/H+ antiporter involved in Na+ and/or Li+ excretion. Na+/H+ antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic. Does not transport K+, Ca2+ or Mg2+.

Enzyme regulationi

Na+ extrusion is completely inhibited by the H+ conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Hydrogen ion transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.63.1.3. the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) antiporter subunit A1
Alternative name(s):
Mnh complex subunit A1
Mrp complex subunit A1
Gene namesi
Name:mnhA1
Synonyms:mrpA1
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 25HelicalSequence analysisAdd BLAST22
Transmembranei30 – 49HelicalSequence analysisAdd BLAST20
Transmembranei79 – 101HelicalSequence analysisAdd BLAST23
Transmembranei108 – 127HelicalSequence analysisAdd BLAST20
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Transmembranei166 – 188HelicalSequence analysisAdd BLAST23
Transmembranei208 – 230HelicalSequence analysisAdd BLAST23
Transmembranei243 – 265HelicalSequence analysisAdd BLAST23
Transmembranei270 – 289HelicalSequence analysisAdd BLAST20
Transmembranei302 – 324HelicalSequence analysisAdd BLAST23
Transmembranei339 – 361HelicalSequence analysisAdd BLAST23
Transmembranei373 – 395HelicalSequence analysisAdd BLAST23
Transmembranei429 – 451HelicalSequence analysisAdd BLAST23
Transmembranei472 – 494HelicalSequence analysisAdd BLAST23
Transmembranei526 – 548HelicalSequence analysisAdd BLAST23
Transmembranei589 – 611HelicalSequence analysisAdd BLAST23
Transmembranei621 – 641HelicalSequence analysisAdd BLAST21
Transmembranei646 – 668HelicalSequence analysisAdd BLAST23
Transmembranei672 – 694HelicalSequence analysisAdd BLAST23
Transmembranei707 – 729HelicalSequence analysisAdd BLAST23
Transmembranei767 – 784HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002170711 – 801Na(+)/H(+) antiporter subunit A1Add BLAST801

Interactioni

Subunit structurei

May form a heterooligomeric complex that consists of seven subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.

Protein-protein interaction databases

STRINGi93062.SACOL0955.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
COG2111. LUCA.

Family and domain databases

InterProiIPR025383. DUF4040.
IPR005663. MrpA/MnhA1/PhaAB.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF13244. DUF4040. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR00940. 2a6301s01. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZNG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLHIAVIL PLIFALIIPI LYRFFKRIHL GWFVLSVPIV IFIYMLTLIK
60 70 80 90 100
TTMSGNTVMK TLNWMPHFGM NFDLYLDGLG LLFSLLISGI GSLVVLYSIG
110 120 130 140 150
YLSKSEQLGN FYCYLLLFMG AMLGVVLSDN VIILYLFWEL TSFSSFLLIS
160 170 180 190 200
FWRERQASIY GAQKSLIITV FGGLSLLGGI ILLAIPTQSF SIQYMIQHAS
210 220 230 240 250
EIQNSPFFIF AMILIMIGAF TKSAQFPFYI WLPDAMEAPT PVSAYLHSAT
260 270 280 290 300
MVKAGLYLIA RMTPIFAASQ GWVWTVTLVG LITLFWASLN ATKQQDLKGI
310 320 330 340 350
LAFSTVSQLG MIMAMLGIGA ISYHYQGDDS KIYAAAFTAA IFHLINHATF
360 370 380 390 400
KGALFMITGA VDHSTGTRDV KKLGGLLTIM PISFTITVIT ALSMAGVPPF
410 420 430 440 450
NGFLSKESFL ETTFTASQAN LFSVDTLGYL FPIIGIVGSV FTFVYSIKFI
460 470 480 490 500
MHIFFGQYKP EQLPKKAHEV SILMLLSPAI LATLVIVFGL FPGILTNSII
510 520 530 540 550
EPATSSINHT VIDDVEFHMF HGLTPAFLST LVIYILGILL IVTFSYWVKL
560 570 580 590 600
LQRQPGKLTF NYWYNRSANV IPNYSEKMTN SYVTDYSRNN LVIIFGALIL
610 620 630 640 650
LTFVTIFSVP FNINFKDVSP IRIFEVCIVI LLLSAAFLIL FAKSRLFSII
660 670 680 690 700
MLSAVGYAVS VLFIFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN
710 720 730 740 750
EKRSFQLTNA LIAGGVGLSV IIIGLIAYGN RHFESISKFY QEHVYDLAHG
760 770 780 790 800
KNMVNVILVD FRGMDTLFES SVLGIAGLAV YTMIKLRKKR QTQGNEVKNH

E
Length:801
Mass (Da):89,386
Last modified:May 1, 1999 - v1
Checksum:i2EEC9AED745917AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015981 Genomic DNA. Translation: BAA35095.1.
DQ659238 Genomic DNA. Translation: ABG67110.1.
RefSeqiWP_042727539.1. NZ_JXOB01000001.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015981 Genomic DNA. Translation: BAA35095.1.
DQ659238 Genomic DNA. Translation: ABG67110.1.
RefSeqiWP_042727539.1. NZ_JXOB01000001.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL0955.

Protein family/group databases

TCDBi2.A.63.1.3. the monovalent cation (k(+) or na(+)):proton antiporter-3 (cpa3) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
COG2111. LUCA.

Family and domain databases

InterProiIPR025383. DUF4040.
IPR005663. MrpA/MnhA1/PhaAB.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF13244. DUF4040. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR00940. 2a6301s01. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMNHA1_STAAU
AccessioniPrimary (citable) accession number: Q9ZNG6
Secondary accession number(s): Q0Q2K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.