ID   Q9ZN80_STRCH            Unreviewed;       592 AA.
AC   Q9ZN80;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 137.
DE   SubName: Full=PkaG {ECO:0000313|EMBL:BAA36343.1};
GN   Name=pkaG {ECO:0000313|EMBL:BAA36343.1};
OS   Streptomyces coelicolor.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1902 {ECO:0000313|EMBL:BAA36343.1};
RN   [1] {ECO:0000313|EMBL:BAA36343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A3 {ECO:0000313|EMBL:BAA36343.1};
RX   PubMed=10627033;
RA   Ogawara H., Aoyagi N., Watanabe M., Urabe H.;
RT   "Sequence and evolutionary analyses of eukaryotic-type protein kinases from
RT   Streptomyces coelicolor A3(2).";
RL   Microbiology 145:3343-3352(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC       protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR   EMBL; AB021679; BAA36343.1; -; Genomic_DNA.
DR   PIR; T42078; T42078.
DR   RefSeq; NP_628652.1; NC_003888.3.
DR   RefSeq; WP_011029689.1; NZ_VNIH01000013.1.
DR   AlphaFoldDB; Q9ZN80; -.
DR   OMA; SALMACI; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR43671:SF13; LD04361P; 1.
DR   PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00560; LamGL; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          15..268
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   592 AA;  61036 MW;  CEBAFFDDF2BD9504 CRC64;
     MSALEPDDPR SVGEYRLLGR LGAGGMGRVF LGRSPGGRLV AVKVVHAELL RRPEFRDRFR
     REVQAARMVS GAFTAPVVDA DPDAPLPWLV TSYIAGPSLE QAVAERGPFD PQAVLTLAAG
     LAEALVSIHA AHLVHRDLKP SNVLLAEDGP RVIDFGIVRS VDADSLTGSG HMAGSPGFMS
     PEQVNGDEVT WASDVFCLGA VLAFAATGTN PFGAGPTPAL LYRVVHNAPD VAAVADPALR
     SLIADCLAKD PAHRPAPREI LARIGPLGGE SATALPHAQQ WTPAARPTRA DAVPTRIVPP
     VAAPPAHQHT RVDTSPAQVY PPAPAPADVR PTATGDGGRR SRRAFLFSGA GALAALGVGT
     GFWLNRPADP DPAEGSAPAP SPSSAPSPPP GPVGLWPLDE ASGQVARDTA GGHDGTVTGV
     AWQGAGEGAA FDGTGSQIVT AGPVLQTGAG RSFTVAAWVR LSAVPGVFAT AVSQDSADAS
     GFYLQYSSED QGWAFARPGL RAVGRTAPAA HVWTHLTGVC DGPARKLHLY VNGVQEAVVE
     DTGPAPATGA FMIGRASFDG QPRDFFPGAI RDVRAFDRAL GPARVAQLAQ LG
//