Reviewed, UniProtKB/Swiss-Prot Q9ZN70 (PPX_PSEAE)

Names and origin

Protein names

Recommended name:
    Exopolyphosphatase
      Short name=ExopolyPase
    EC=3.6.1.11
Alternative name(s):
    Metaphosphatase

Gene names

Name:	ppx
Ordered Locus Names:	PA5241

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate By similarity.
Catalytic activity	(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the gppA/ppx family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	exopolyphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Exopolyphosphatase		PRO_0000194303

Sequences

	Sequence		Length	Mass (Da)
	Q9ZN70-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 91FDA10CFA04E1D4	FASTA	506	56,419
	10 20 30 40 50 60 MDLQSMPQKP AEAFPLIAAL DLGSNSFHLC LAKANIHGEV RILERLGEKV QLAAGLDEER 70 80 90 100 110 120 NLSEEATQRG LDCLRRFAQF ISGMPQGSVR VVATNALREA RNRSDFIRRA EEVLGHPVEV 130 140 150 160 170 180 ISGREEARLI YLGVANSMPD SGGRRLVSDI GGGSTEFIIG QGFESELRES LQMGCVSYTQ 190 200 210 220 230 240 RYFRDGKITP ARYAQAYTAA RLELMGIENS LRRLGWQQAV GASGTIRAVA LAIKAGGHGN 250 260 270 280 290 300 GEISPDGLAW LKRKVLKLGD VEKLDLEGIK PDRRTIFPAG LAILEAIFDA LELEQMVHSE 310 320 330 340 350 360 GALREGVLYD LVGRHQHEDV RERTISSLMQ RYHVDPEQAS RVEAKALKVL AEVGDAWELN 370 380 390 400 410 420 GELHRDLLSW GARVHEIGLD IAHYHYHKHG AYLIEHSDLA GFSRQDQQML SLLVRGHRRN 430 440 450 460 470 480 IPADKLAEFA EEGDKLVRLC IVLRFAILFH HIRGTQEMPS VRLKAEPKSL SVTFPEGWLE 490 500 ANPLTQADFA QEAEWLKRVG YSLNVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene for an exopolyphosphatase of Pseudomonas aeruginosa." Miyake T., Shiba T., Kameda A., Ihara Y., Munekata M., Ishige K., Noguchi T. DNA Res. 6:103-108(1999) [PubMed: 10382967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB022715 Genomic DNA. Translation: BAA74460.1. AE004091 Genomic DNA. Translation: AAG08626.1.
PIR	H82991.
RefSeq	NP_253928.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	877947.
GenomeReviews	Gene locus PA5241 in contig AE004091_GR.
KEGG	pae:PA5241.
Organism-specific databases
PseudoCAP	PA5241.
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZN70.
OMA	Q9ZN70. VREAPNG.
Enzyme and pathway databases
BioCyc	PAER208964:PA5241-MON.
BRENDA	3.6.1.11. 354.
Family and domain databases
InterPro	IPR003695. Ppx_GppA. [Graphical view]
Pfam	PF02541. Ppx-GppA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPX_PSEAE

Accession

Primary (citable) accession number: Q9ZN70

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)