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Protein

Exopolyphosphatase

Gene

ppx

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate (By similarity).By similarity

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. exopolyphosphatase activity Source: PseudoCAP
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. bacterial-type flagellum-dependent swarming motility Source: PseudoCAP
  2. bacterial-type flagellum-dependent swimming motility Source: PseudoCAP
  3. cellular response to nitrogen starvation Source: PseudoCAP
  4. cellular response to phosphate starvation Source: PseudoCAP
  5. glycolipid biosynthetic process Source: PseudoCAP
  6. pathogenesis Source: PseudoCAP
  7. polyphosphate catabolic process Source: InterPro
  8. quorum sensing Source: PseudoCAP
  9. single-species biofilm formation Source: PseudoCAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
Name:ppx
Ordered Locus Names:PA5241
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506ExopolyphosphatasePRO_0000194303Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5241.

Structurei

3D structure databases

ProteinModelPortaliQ9ZN70.
SMRiQ9ZN70. Positions 18-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.Curated

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
InParanoidiQ9ZN70.
KOiK01524.
OMAiGCVSFTQ.
OrthoDBiEOG6M6JN6.
PhylomeDBiQ9ZN70.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZN70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLQSMPQKP AEAFPLIAAL DLGSNSFHLC LAKANIHGEV RILERLGEKV
60 70 80 90 100
QLAAGLDEER NLSEEATQRG LDCLRRFAQF ISGMPQGSVR VVATNALREA
110 120 130 140 150
RNRSDFIRRA EEVLGHPVEV ISGREEARLI YLGVANSMPD SGGRRLVSDI
160 170 180 190 200
GGGSTEFIIG QGFESELRES LQMGCVSYTQ RYFRDGKITP ARYAQAYTAA
210 220 230 240 250
RLELMGIENS LRRLGWQQAV GASGTIRAVA LAIKAGGHGN GEISPDGLAW
260 270 280 290 300
LKRKVLKLGD VEKLDLEGIK PDRRTIFPAG LAILEAIFDA LELEQMVHSE
310 320 330 340 350
GALREGVLYD LVGRHQHEDV RERTISSLMQ RYHVDPEQAS RVEAKALKVL
360 370 380 390 400
AEVGDAWELN GELHRDLLSW GARVHEIGLD IAHYHYHKHG AYLIEHSDLA
410 420 430 440 450
GFSRQDQQML SLLVRGHRRN IPADKLAEFA EEGDKLVRLC IVLRFAILFH
460 470 480 490 500
HIRGTQEMPS VRLKAEPKSL SVTFPEGWLE ANPLTQADFA QEAEWLKRVG

YSLNVR
Length:506
Mass (Da):56,419
Last modified:May 1, 1999 - v1
Checksum:i91FDA10CFA04E1D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022715 Genomic DNA. Translation: BAA74460.1.
AE004091 Genomic DNA. Translation: AAG08626.1.
PIRiH82991.
RefSeqiNP_253928.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08626; AAG08626; PA5241.
GeneIDi877947.
KEGGipae:PA5241.
PATRICi19845333. VBIPseAer58763_5493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022715 Genomic DNA. Translation: BAA74460.1.
AE004091 Genomic DNA. Translation: AAG08626.1.
PIRiH82991.
RefSeqiNP_253928.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ9ZN70.
SMRiQ9ZN70. Positions 18-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA5241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08626; AAG08626; PA5241.
GeneIDi877947.
KEGGipae:PA5241.
PATRICi19845333. VBIPseAer58763_5493.

Organism-specific databases

PseudoCAPiPA5241.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
InParanoidiQ9ZN70.
KOiK01524.
OMAiGCVSFTQ.
OrthoDBiEOG6M6JN6.
PhylomeDBiQ9ZN70.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene for an exopolyphosphatase of Pseudomonas aeruginosa."
    Miyake T., Shiba T., Kameda A., Ihara Y., Munekata M., Ishige K., Noguchi T.
    DNA Res. 6:103-108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiPPX_PSEAE
AccessioniPrimary (citable) accession number: Q9ZN70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.