Reviewed, UniProtKB/Swiss-Prot Q9ZN54 (CYNT_HELPJ)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase
    EC=4.2.1.1
Alternative name(s):
    Carbonate dehydratase

Gene names

Name:	cynT
Ordered Locus Names:	jhp_0004

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbon utilization Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Carbonic anhydrase		PRO_0000077462
Sites
	Metal binding	38	1	Zinc By similarity
	Metal binding	40	1	Zinc By similarity
	Metal binding	99	1	Zinc By similarity
	Metal binding	102	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZN54-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 48ABBA5DD912D1CF	FASTA	221	25,741
	10 20 30 40 50 60 MEAFLGALEF QENEYEEFKE LYESLKTKQK PHTLFISCVD SRVVPNLITG TQPGELYVIR 70 80 90 100 110 120 NMGNVIPPKT SYKESLSTIA SVEYAIAHVG VQNLIICGHS DCGACGSIHL IHDETTKAKT 130 140 150 160 170 180 PYIANWIQFL EPIKEELKNH PQFSNHFAKR SWLTERLNAR LQLNNLLSYD FIQERVINNE 190 200 210 220 LKIFGWHYII ETGRIYNYNF ESHFFEPIEE TIKQRISHEN F

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05588.1.
PIR	F71985.
RefSeq	NP_222726.1.
3D structure databases
HSSP	HSSP built from PDB template 1EKJ based on UniProtKB P17067.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZN54.
Genome annotation databases
GeneID	889283.
GenomeReviews	Gene locus jhp_0004 in contig AE001439_GR.
KEGG	hpj:jhp0004.
NMPDR	fig|85963.1.peg.4.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZN54.
OMA	VANWLRY.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0004-MON.
BRENDA	4.2.1.1. 295085.
Family and domain databases
InterPro	IPR001765. Carbonic_anhydrase. IPR015892. Carbonic_anhydrase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHER	PTHR11002. Carbonic_anhydrase. 1 hit.
Pfam	PF00484. Pro_CA. 1 hit. [Graphical view]
PROSITE	PS00704. PROK_CO2_ANHYDRASE_1. False negative. PS00705. PROK_CO2_ANHYDRASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYNT_HELPJ

Accession

Primary (citable) accession number: Q9ZN54

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)