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Q9ZN37

- CISY_HELPJ

UniProt

Q9ZN37 - CISY_HELPJ

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Protein

Citrate synthase

Gene

gltA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei314 – 3141PROSITE-ProRule annotation
Active sitei372 – 3721PROSITE-ProRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-27-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:jhp_0022
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Citrate synthasePRO_0000169947Add
BLAST

Proteomic databases

PRIDEiQ9ZN37.

Interactioni

Protein-protein interaction databases

IntActiQ9ZN37. 2 interactions.
STRINGi85963.jhp0022.

Structurei

3D structure databases

ProteinModelPortaliQ9ZN37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
KOiK01647.
OMAiKETCDEV.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZN37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVTLINNEN NARYEFETIE CTRGPKAVDF SKLFETTGFF SYDPGYSSTA
60 70 80 90 100
GCQSKISYIN GKKGELYYRG HRIEDLVAKY KYVDVCRLLL TGELPKNQDE
110 120 130 140 150
SLEFELELRH RSFVHESLLN MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ
160 170 180 190 200
NMHTEEDYQT MARRIVAKIP TLAAICYRNE VGAPIIYPDI ARSYVENILF
210 220 230 240 250
MLRGYPYSRL KHTTQGEVGI TPLEVEAFDK ILTLHADHGQ NASSTTVRNV
260 270 280 290 300
ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV
310 320 330 340 350
KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA
360 370 380 390 400
KVEEIALKDE YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG
410 420
WCAQLLEHVK SPQARITRPR QVYVGD
Length:426
Mass (Da):48,262
Last modified:May 1, 1999 - v1
Checksum:i373FEE23B1C6239A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05606.1.
PIRiD71982.
RefSeqiNP_222744.1. NC_000921.1.
WP_000117349.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05606; AAD05606; jhp_0022.
GeneIDi889056.
KEGGihpj:jhp0022.
PATRICi20604625. VBIHelPyl98156_0027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05606.1 .
PIRi D71982.
RefSeqi NP_222744.1. NC_000921.1.
WP_000117349.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZN37.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ZN37. 2 interactions.
STRINGi 85963.jhp0022.

Proteomic databases

PRIDEi Q9ZN37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05606 ; AAD05606 ; jhp_0022 .
GeneIDi 889056.
KEGGi hpj:jhp0022.
PATRICi 20604625. VBIHelPyl98156_0027.

Phylogenomic databases

eggNOGi COG0372.
KOi K01647.
OMAi KETCDEV.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci HPYL85963:GJB9-27-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiCISY_HELPJ
AccessioniPrimary (citable) accession number: Q9ZN37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3