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Q9ZN37

- CISY_HELPJ

UniProt

Q9ZN37 - CISY_HELPJ

Protein

Citrate synthase

Gene

gltA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei314 – 3141PROSITE-ProRule annotation
    Active sitei372 – 3721PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-27-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:jhp_0022
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Citrate synthasePRO_0000169947Add
    BLAST

    Proteomic databases

    PRIDEiQ9ZN37.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9ZN37. 2 interactions.
    STRINGi85963.jhp0022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZN37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    KOiK01647.
    OMAiKETCDEV.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZN37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVTLINNEN NARYEFETIE CTRGPKAVDF SKLFETTGFF SYDPGYSSTA    50
    GCQSKISYIN GKKGELYYRG HRIEDLVAKY KYVDVCRLLL TGELPKNQDE 100
    SLEFELELRH RSFVHESLLN MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ 150
    NMHTEEDYQT MARRIVAKIP TLAAICYRNE VGAPIIYPDI ARSYVENILF 200
    MLRGYPYSRL KHTTQGEVGI TPLEVEAFDK ILTLHADHGQ NASSTTVRNV 250
    ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV 300
    KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA 350
    KVEEIALKDE YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG 400
    WCAQLLEHVK SPQARITRPR QVYVGD 426
    Length:426
    Mass (Da):48,262
    Last modified:May 1, 1999 - v1
    Checksum:i373FEE23B1C6239A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05606.1.
    PIRiD71982.
    RefSeqiNP_222744.1. NC_000921.1.
    WP_000117349.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD05606; AAD05606; jhp_0022.
    GeneIDi889056.
    KEGGihpj:jhp0022.
    PATRICi20604625. VBIHelPyl98156_0027.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05606.1 .
    PIRi D71982.
    RefSeqi NP_222744.1. NC_000921.1.
    WP_000117349.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZN37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ZN37. 2 interactions.
    STRINGi 85963.jhp0022.

    Proteomic databases

    PRIDEi Q9ZN37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD05606 ; AAD05606 ; jhp_0022 .
    GeneIDi 889056.
    KEGGi hpj:jhp0022.
    PATRICi 20604625. VBIHelPyl98156_0027.

    Phylogenomic databases

    eggNOGi COG0372.
    KOi K01647.
    OMAi KETCDEV.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci HPYL85963:GJB9-27-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiCISY_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZN37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3