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Q9ZN37 (CISY_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:jhp_0022
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Citrate synthase
PRO_0000169947

Sites

Active site3141 By similarity
Active site3721 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZN37 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 373FEE23B1C6239A

FASTA42648,262
        10         20         30         40         50         60 
MSVTLINNEN NARYEFETIE CTRGPKAVDF SKLFETTGFF SYDPGYSSTA GCQSKISYIN 

        70         80         90        100        110        120 
GKKGELYYRG HRIEDLVAKY KYVDVCRLLL TGELPKNQDE SLEFELELRH RSFVHESLLN 

       130        140        150        160        170        180 
MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ NMHTEEDYQT MARRIVAKIP TLAAICYRNE 

       190        200        210        220        230        240 
VGAPIIYPDI ARSYVENILF MLRGYPYSRL KHTTQGEVGI TPLEVEAFDK ILTLHADHGQ 

       250        260        270        280        290        300 
NASSTTVRNV ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV 

       310        320        330        340        350        360 
KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA KVEEIALKDE 

       370        380        390        400        410        420 
YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG WCAQLLEHVK SPQARITRPR 


QVYVGD 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD05606.1.
PIRD71982.
RefSeqNP_222744.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZN37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9ZN37. 2 interactions.
STRING85963.jhp0022.

Proteomic databases

PRIDEQ9ZN37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD05606; AAD05606; jhp_0022.
GeneID889056.
KEGGhpj:jhp0022.
PATRIC20604625. VBIHelPyl98156_0027.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
KOK01647.
OMANKEDGVR.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-27-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_HELPJ
AccessionPrimary (citable) accession number: Q9ZN37
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 13, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways