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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114NADPBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei139SubstrateBy similarity1
Binding sitei162SubstrateBy similarity1
Sitei169Critical for catalysisBy similarity1
Sitei239Critical for catalysisBy similarity1
Metal bindingi316Magnesium or manganeseBy similarity1
Binding sitei361NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei400NADPBy similarity1
Binding sitei404NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi348 – 354NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:jhp_0023
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835531 – 425Isocitrate dehydrogenase [NADP]Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9ZN36.

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0023.

Structurei

3D structure databases

ProteinModelPortaliQ9ZN36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
KOiK00031.
OMAiTERESWI.
OrthoDBiPOG091H01VB.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZN36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNPKILQK PKEGEEITIK DGKLHVPNYP IIPFIEGDGI GSDITPAMIK
60 70 80 90 100
VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE
110 120 130 140 150
AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV
160 170 180 190 200
KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVEKIRFP
210 220 230 240 250
ESSGVGIKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF
260 270 280 290 300
MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL
310 320 330 340 350
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT
360 370 380 390 400
APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY
410 420
DFARLMDGAK EVKCSEFASV MIENM
Length:425
Mass (Da):47,462
Last modified:May 1, 1999 - v1
Checksum:i356FE749774E053A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05607.1.
PIRiE71982.
RefSeqiWP_000323928.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05607; AAD05607; jhp_0023.
KEGGihpj:jhp_0023.
PATRICi20604627. VBIHelPyl98156_0028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05607.1.
PIRiE71982.
RefSeqiWP_000323928.1. NC_000921.1.

3D structure databases

ProteinModelPortaliQ9ZN36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85963.jhp0023.

Proteomic databases

PRIDEiQ9ZN36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD05607; AAD05607; jhp_0023.
KEGGihpj:jhp_0023.
PATRICi20604627. VBIHelPyl98156_0028.

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
KOiK00031.
OMAiTERESWI.
OrthoDBiPOG091H01VB.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 3 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH_HELPJ
AccessioniPrimary (citable) accession number: Q9ZN36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.