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Q9ZN36

- IDH_HELPJ

UniProt

Q9ZN36 - IDH_HELPJ

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, jhp_0023
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NADP By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei125 – 1251Substrate By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei139 – 1391Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Sitei169 – 1691Critical for catalysis By similarity
Sitei239 – 2391Critical for catalysis By similarity
Metal bindingi316 – 3161Magnesium or manganese By similarity
Binding sitei361 – 3611NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei400 – 4001NADP By similarity
Binding sitei404 – 4041NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi348 – 3547NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-28-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:jhp_0023
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Isocitrate dehydrogenase [NADP]
PRO_0000083553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9ZN36.

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0023.

Structurei

3D structure databases

ProteinModelPortaliQ9ZN36.
SMRiQ9ZN36. Positions 11-425.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZN36-1 [UniParc]FASTAAdd to Basket

« Hide

MAYNPKILQK PKEGEEITIK DGKLHVPNYP IIPFIEGDGI GSDITPAMIK    50
VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE 100
AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV 150
KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVEKIRFP 200
ESSGVGIKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF 250
MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL 300
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT 350
APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY 400
DFARLMDGAK EVKCSEFASV MIENM 425
Length:425
Mass (Da):47,462
Last modified:May 1, 1999 - v1
Checksum:i356FE749774E053A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05607.1.
PIRiE71982.
RefSeqiNP_222745.1. NC_000921.1.
WP_000323928.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05607; AAD05607; jhp_0023.
GeneIDi889267.
KEGGihpj:jhp0023.
PATRICi20604627. VBIHelPyl98156_0028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05607.1 .
PIRi E71982.
RefSeqi NP_222745.1. NC_000921.1.
WP_000323928.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZN36.
SMRi Q9ZN36. Positions 11-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0023.

Proteomic databases

PRIDEi Q9ZN36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05607 ; AAD05607 ; jhp_0023 .
GeneIDi 889267.
KEGGi hpj:jhp0023.
PATRICi 20604627. VBIHelPyl98156_0028.

Phylogenomic databases

eggNOGi COG0538.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-28-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiIDH_HELPJ
AccessioniPrimary (citable) accession number: Q9ZN36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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