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Q9ZMY5 (MQO_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate:quinone oxidoreductase
EC=1.1.5.4
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene names
Name:mqo
Ordered Locus Names:jhp_0079
OrganismHelicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain By similarity. HAMAP MF_00212

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD. The FAD is tightly bound By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00212.

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCell membrane
Membrane
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Malate:quinone oxidoreductase HAMAP MF_00212
PRO_0000128718

Sequences

Sequence LengthMass (Da)Tools
Q9ZMY5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 7E42E03268E99E1C

FASTA45050,755
        10         20         30         40         50         60 
MSMEFDAVII GGGVSGCATF YTLSEYSSLK RVAIVEKCSK LAQISSSAKA NSQTIHDGSI 

        70         80         90        100        110        120 
ETNYTPEKAK KVRLSAYKTR QYALNKGLQN EVIFETQKMA IGVGDEECEF MKKRYESFKE 

       130        140        150        160        170        180 
IFVGLEEFDK QKIKELEPNV ILGANGIDRH ENIIGHGYRK DWSTMNFAKL SENFVEEALK 

       190        200        210        220        230        240 
LKPNNQVFLN FKVKKIEKRN DTYAVISEDA EEVYAKFVLV NAGSYALPLA QSMGYGLDLG 

       250        260        270        280        290        300 
CLPVAGSFYF VPDLLRGKVY TVQNPKLPFA AVHGDPDAVI KGKTRIGPTA LTMPKLERNK 

       310        320        330        340        350        360 
CWLKGISLEL LKMDLNRDVF KIAFDLMSDK EIRNYVFKNM VFELPIIGKR KFLKDAQKII 

       370        380        390        400        410        420 
PTLSLEDLEY AHGFGEVRPQ VLDRTKRKLE LGEKKICTHK GITFNMTPSP GATSCLQNAL 

       430        440        450 
VDSQEIAAYL GESFELERFY KDLSPEELEN

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001439 Genomic DNA. Translation: AAD05663.1.
PIRB71976.
RefSeqNP_222801.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZMY5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZMY5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID890383.
GenomeReviewsGene locus jhp_0079 in contig AE001439_GR.
KEGGhpj:jhp0079.
NMPDRfig|85963.1.peg.79.
PATRIC20604753. VBIHelPyl98156_0090.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0579.
HOGENOMHBG321270.
OMAFELERFY.
PhylomeDBQ9ZMY5.
ProtClustDBCLSK872267.

Enzyme and pathway databases

BioCycHPYL85963:JHP0079-MONOMER.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMQO_HELPJ
AccessionPrimary (citable) accession number: Q9ZMY5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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