Reviewed, UniProtKB/Swiss-Prot Q9ZMY5 (MQO_HELPJ)

Names and origin

Protein names

Recommended name:
    Malate:quinone oxidoreductase
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor]
    MQO

Gene names

Name:	mqo
Ordered Locus Names:	jhp_0079

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes oxidation of malate to oxaloacetate in the citric acid cycle. Donates electrons to quinones of the electron transfer chain By similarity.
Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor.
Cofactor	FAD. The FAD is tightly bound By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subcellular location	Cell membrane; Peripheral membrane proteinBy similarity.
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Cell membrane Membrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Malate:quinone oxidoreductase		PRO_0000128718

Sequences

	Sequence		Length	Mass (Da)
	Q9ZMY5-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 7E42E03268E99E1C	FASTA	450	50,755
	10 20 30 40 50 60 MSMEFDAVII GGGVSGCATF YTLSEYSSLK RVAIVEKCSK LAQISSSAKA NSQTIHDGSI 70 80 90 100 110 120 ETNYTPEKAK KVRLSAYKTR QYALNKGLQN EVIFETQKMA IGVGDEECEF MKKRYESFKE 130 140 150 160 170 180 IFVGLEEFDK QKIKELEPNV ILGANGIDRH ENIIGHGYRK DWSTMNFAKL SENFVEEALK 190 200 210 220 230 240 LKPNNQVFLN FKVKKIEKRN DTYAVISEDA EEVYAKFVLV NAGSYALPLA QSMGYGLDLG 250 260 270 280 290 300 CLPVAGSFYF VPDLLRGKVY TVQNPKLPFA AVHGDPDAVI KGKTRIGPTA LTMPKLERNK 310 320 330 340 350 360 CWLKGISLEL LKMDLNRDVF KIAFDLMSDK EIRNYVFKNM VFELPIIGKR KFLKDAQKII 370 380 390 400 410 420 PTLSLEDLEY AHGFGEVRPQ VLDRTKRKLE LGEKKICTHK GITFNMTPSP GATSCLQNAL 430 440 450 VDSQEIAAYL GESFELERFY KDLSPEELEN

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05663.1.
PIR	B71976.
RefSeq	NP_222801.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	890383.
GenomeReviews	Gene locus jhp_0079 in contig AE001439_GR.
KEGG	hpj:jhp0079.
NMPDR	fig|85963.1.peg.79.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZMY5.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0079-MON.
Family and domain databases
HAMAP	MF_00212. [Tree]
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

MQO_HELPJ

Accession

Primary (citable) accession number: Q9ZMY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 4, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)