Reviewed, UniProtKB/Swiss-Prot Q9ZMY2 (MTNN_HELPJ)

Names and origin

Protein names

Recommended name:
    MTA/SAH nucleosidase
    EC=3.2.2.9
Alternative name(s):
    5'-methylthioadenosine nucleosidase
    S-adenosylhomocysteine nucleosidase

Gene names

Name:	mtnN
Synonyms:	mtn
Ordered Locus Names:	jhp_0082

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) By similarity.
Catalytic activity	S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine. S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine. Methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose.
Sequence similarities	Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine salvage Inferred from electronic annotation. Source: InterPro nucleoside catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenosylhomocysteine nucleosidase activity Inferred from electronic annotation. Source: EC methylthioadenosine nucleosidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	MTA/SAH nucleosidase		PRO_0000164444

Sequences

	Sequence		Length	Mass (Da)
	Q9ZMY2-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: F1E128A8160512C9	FASTA	230	25,020
	10 20 30 40 50 60 MQKIGILGAM REEITPILEL FGVDFEEIPL GGNVFHKGVY HNKEIIVAYS KIGKVHSTLT 70 80 90 100 110 120 TTSMILAFGV QKVLFSGVAG SLVKDLKIND LLVATQLVQH DVDLSAFDHP LGFIPESAIF 130 140 150 160 170 180 IETSGSLNAL AKKIANEQHI ALKEGVIASG DQFVHSKERK EFLVSEFKAS AVEMEGASVA 190 200 210 220 230 FVCQKFGVPC CVLRSISDNA DEKAGMSFDE FLEKSAHTSA KFLKSMVDEL

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05666.1.
PIR	E71976.
RefSeq	NP_222804.1.
3D structure databases
HSSP	HSSP built from PDB template 1NC3 based on UniProtKB P24247.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZMY2.
Genome annotation databases
GeneID	889391.
GenomeReviews	Gene locus jhp_0082 in contig AE001439_GR.
KEGG	hpj:jhp0082.
NMPDR	fig|85963.1.peg.82.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZMY2.
OMA	AQVCHQF.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0082-MON.
BRENDA	3.2.2.9. 295085.
Family and domain databases
InterPro	IPR010049. MTA_SAH_Nsdase. IPR000845. Nucleoside_phosphorylase. IPR018017. Nucleoside_phosphorylase_1. [Graphical view]
PANTHER	PTHR21234. PNP_UDP. 1 hit.
Pfam	PF01048. PNP_UDP_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01704. MTA/SAH-Nsdase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTNN_HELPJ

Accession

Primary (citable) accession number: Q9ZMY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)