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Q9ZMX5

- THRC_HELPJ

UniProt

Q9ZMX5 - THRC_HELPJ

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Protein

Threonine synthase

Gene

thrC

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-97-MONOMER.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:jhp_0090
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Threonine synthasePRO_0000185634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0090.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
KOiK01733.
OMAiILLWLES.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZMX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPFVPTRSLK ERKIDFIEAV LNPNAPKGGL YTLEHFETLE WQDCLGMSYS
60 70 80 90 100
ELVEHVFELL NLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL
110 120 130 140 150
YHGPSLAFKD MALQPLASLF SNLAVGKNEK YLVLVSTSGD TGPATLEGLA
160 170 180 190 200
GMPNVFVVCL YPKDGTSLVQ KLQMVTQNAS NLKVFGVSGD FDDAQNALKN
210 220 230 240 250
LLKDDDFNEA LKARQLKLSV ANSVNFGRIA FQIVYHIWGF LELYKKGAIN
260 270 280 290 300
SKEKITLAIP SGNFGNALGA FYAKKMGLNI AKIKVVTNSN DVLREFIETG
310 320 330 340 350
RYDLTKRSLK QTFSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF
360 370 380 390 400
YALKPKELAL LQEHFSCASC SDEDCLKTIQ EVYAEHQYLI DPHTATALNA
410 420 430 440 450
SLKTHEKTLV SATASYEKFP KTTLLALNEQ KKNDDDKAAL ETLKNSYNTP
460 470 480
DSQRLDDLFE RGIKHQEVLK LNEIKSSILL WLENTH
Length:486
Mass (Da):54,654
Last modified:May 1, 1999 - v1
Checksum:i3A3C66613ADB4920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05671.1.
PIRiA71975.
RefSeqiNP_222811.1. NC_000921.1.
WP_001117379.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05671; AAD05671; jhp_0090.
GeneIDi889337.
KEGGihpj:jhp0090.
PATRICi20604784. VBIHelPyl98156_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05671.1 .
PIRi A71975.
RefSeqi NP_222811.1. NC_000921.1.
WP_001117379.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05671 ; AAD05671 ; jhp_0090 .
GeneIDi 889337.
KEGGi hpj:jhp0090.
PATRICi 20604784. VBIHelPyl98156_0104.

Phylogenomic databases

eggNOGi COG0498.
KOi K01733.
OMAi ILLWLES.
OrthoDBi EOG65BDJX.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .
BioCyci HPYL85963:GJB9-97-MONOMER.

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiTHRC_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3