Reviewed, UniProtKB/Swiss-Prot Q9ZMX5 (THRC_HELPJ)

Names and origin

Protein names

Recommended name:
    Threonine synthase
    EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	jhp_0090

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	Threonine synthase		PRO_0000185634
Amino acid modifications
	Modified residue	109	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZMX5-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3A3C66613ADB4920	FASTA	486	54,654
	10 20 30 40 50 60 MPFVPTRSLK ERKIDFIEAV LNPNAPKGGL YTLEHFETLE WQDCLGMSYS ELVEHVFELL 70 80 90 100 110 120 NLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL YHGPSLAFKD MALQPLASLF 130 140 150 160 170 180 SNLAVGKNEK YLVLVSTSGD TGPATLEGLA GMPNVFVVCL YPKDGTSLVQ KLQMVTQNAS 190 200 210 220 230 240 NLKVFGVSGD FDDAQNALKN LLKDDDFNEA LKARQLKLSV ANSVNFGRIA FQIVYHIWGF 250 260 270 280 290 300 LELYKKGAIN SKEKITLAIP SGNFGNALGA FYAKKMGLNI AKIKVVTNSN DVLREFIETG 310 320 330 340 350 360 RYDLTKRSLK QTFSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF YALKPKELAL 370 380 390 400 410 420 LQEHFSCASC SDEDCLKTIQ EVYAEHQYLI DPHTATALNA SLKTHEKTLV SATASYEKFP 430 440 450 460 470 480 KTTLLALNEQ KKNDDDKAAL ETLKNSYNTP DSQRLDDLFE RGIKHQEVLK LNEIKSSILL WLENTH

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05671.1.
PIR	A71975.
RefSeq	NP_222811.1.
3D structure databases
HSSP	HSSP built from PDB template 1KL7 based on UniProtKB P16120.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZMX5.
Genome annotation databases
GeneID	889337.
GenomeReviews	Gene locus jhp_0090 in contig AE001439_GR.
KEGG	hpj:jhp0090.
NMPDR	fig|85963.1.peg.89.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZMX5.
OMA	YPKDGTS.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0090-MON.
BRENDA	4.2.3.1. 295085.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_HELPJ

Accession

Primary (citable) accession number: Q9ZMX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)