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Q9ZMX5

- THRC_HELPJ

UniProt

Q9ZMX5 - THRC_HELPJ

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Protein
Threonine synthase
Gene
thrC, jhp_0090
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-97-MONOMER.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:jhp_0090
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Threonine synthase
PRO_0000185634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0090.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMX5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0498.
KOiK01733.
OMAiILLWLES.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZMX5-1 [UniParc]FASTAAdd to Basket

« Hide

MPFVPTRSLK ERKIDFIEAV LNPNAPKGGL YTLEHFETLE WQDCLGMSYS    50
ELVEHVFELL NLEIPKNLLA SALKRYENFD NPKNPAPIFA LNERLFVQEL 100
YHGPSLAFKD MALQPLASLF SNLAVGKNEK YLVLVSTSGD TGPATLEGLA 150
GMPNVFVVCL YPKDGTSLVQ KLQMVTQNAS NLKVFGVSGD FDDAQNALKN 200
LLKDDDFNEA LKARQLKLSV ANSVNFGRIA FQIVYHIWGF LELYKKGAIN 250
SKEKITLAIP SGNFGNALGA FYAKKMGLNI AKIKVVTNSN DVLREFIETG 300
RYDLTKRSLK QTFSPAMDIL KSSNVERALF SLFGFERTLE LMQALEEEKF 350
YALKPKELAL LQEHFSCASC SDEDCLKTIQ EVYAEHQYLI DPHTATALNA 400
SLKTHEKTLV SATASYEKFP KTTLLALNEQ KKNDDDKAAL ETLKNSYNTP 450
DSQRLDDLFE RGIKHQEVLK LNEIKSSILL WLENTH 486
Length:486
Mass (Da):54,654
Last modified:May 1, 1999 - v1
Checksum:i3A3C66613ADB4920
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05671.1.
PIRiA71975.
RefSeqiNP_222811.1. NC_000921.1.
WP_001117379.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05671; AAD05671; jhp_0090.
GeneIDi889337.
KEGGihpj:jhp0090.
PATRICi20604784. VBIHelPyl98156_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05671.1 .
PIRi A71975.
RefSeqi NP_222811.1. NC_000921.1.
WP_001117379.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05671 ; AAD05671 ; jhp_0090 .
GeneIDi 889337.
KEGGi hpj:jhp0090.
PATRICi 20604784. VBIHelPyl98156_0104.

Phylogenomic databases

eggNOGi COG0498.
KOi K01733.
OMAi ILLWLES.
OrthoDBi EOG65BDJX.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .
BioCyci HPYL85963:GJB9-97-MONOMER.

Family and domain databases

Gene3Di 3.90.1380.10. 1 hit.
InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiTHRC_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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