Reviewed, UniProtKB/Swiss-Prot Q9ZMU7 (SDHL_HELPJ)

Names and origin

Protein names

Recommended name:
    L-serine dehydratase
      Short name=SDH
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
      Short name=L-SD

Gene names

Name:	sdaA
Ordered Locus Names:	jhp_0120

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster Probable.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	L-serine dehydratase		PRO_0000171908

Sequences

	Sequence		Length	Mass (Da)
	Q9ZMU7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 48248F71BE7C7713	FASTA	455	49,229
	10 20 30 40 50 60 MASFSILSIF KIGVGPSSSH TIGPMEAGAR FCGLLKGILE QVERVQITLH GSLALTGKGH 70 80 90 100 110 120 LSDEAVLIGL HGIYANELDI TTKKALLHEA FENKVLKLAN QHHIPFDYAK DLIFDNKPLA 130 140 150 160 170 180 RHQNALILKA FNAKNEVLKE ETYYSVGGGF VYTEKELDNL SEEGENESVA YDFSSAKELL 190 200 210 220 230 240 ELCQKHQKSI AEIVRLRENA LKNHPDATMT KIYHAMLECY HNGANSKERY LPGSLKVTRL 250 260 270 280 290 300 APSVKTRLEK HPTSGKDPLA LIDYISLYAR SIAEENASGG KVVTAPTNGA CAVVPSVLSY 310 320 330 340 350 360 AKNHLFENLS QKSINDFLLT SAAIGYLYKK NASLSGAEAG CQAEIGVASS MAAGGLAHLC 370 380 390 400 410 420 QATTQQVLIA SEIAMEHHLG LTCDPVGGLV QIPCIERNVL GAIKAISASK LALEDEYKPK 430 440 450 VSLDEVIATM YATGKDMNEK YKETSLGGLA KTLKC

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05697.1.
PIR	B71971.
RefSeq	NP_222841.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZMU7.
Genome annotation databases
GeneID	889452.
GenomeReviews	Gene locus jhp_0120 in contig AE001439_GR.
KEGG	hpj:jhp0120.
NMPDR	fig|85963.1.peg.119.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZMU7.
OMA	DPDIIPA.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0120-MON.
BRENDA	4.3.1.17. 295085.
Family and domain databases
InterPro	IPR004644. Fe-S_L-Ser_mono. IPR005130. Ser_deHydtase_asu. IPR005131. Ser_deHydtase_bsu. [Graphical view]
Pfam	PF03313. SDH_alpha. 1 hit. PF03315. SDH_beta. 1 hit. [Graphical view]
TIGRFAMs	TIGR00720. sda_mono. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHL_HELPJ

Accession

Primary (citable) accession number: Q9ZMU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)