Reviewed, UniProtKB/Swiss-Prot Q9ZMU4 (BCP_HELPJ)

Names and origin

Protein names

Recommended name:
    Putative peroxiredoxin bcp
    EC=1.11.1.15
Alternative name(s):
    Thioredoxin reductase
    Bacterioferritin comigratory protein homolog

Gene names

Name:	bcp
Ordered Locus Names:	jhp_0124

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Sequence similarities	Belongs to the ahpC/TSA family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	Putative peroxiredoxin bcp		PRO_0000135139
Regions
	Domain	4 – 152	149	Thioredoxin
Sites
	Active site	46	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZMU4-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 46DFE89F70D05DA1	FASTA	152	17,146
	10 20 30 40 50 60 MEKLEVGQLA PDFRLKNSDG VEISLKDLLH KKVVLYFYPK DNTPGCTLEA KDFSALFSEF 70 80 90 100 110 120 EKKNAVVVGV SPDNSQSHQK FISQCSLNVI LLCDEDKKVA NLYKAYGKRM LYGKEHLGII 130 140 150 RSTFIINTQG VLEKCFYNVK AKGHAQKVLE SL

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD05701.1.
PIR	F71971.
RefSeq	NP_222845.1.
3D structure databases
SMR	Q9ZMU4. Positions 4-143.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZMU4.
Genome annotation databases
GeneID	889445.
GenomeReviews	Gene locus jhp_0124 in contig AE001439_GR.
KEGG	hpj:jhp0124.
NMPDR	fig|85963.1.peg.123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1225.
HOGENOM	HBG493509.
OMA	TFIINTQ.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0124-MONOMER.
BRENDA	1.11.1.15. 295085.
Family and domain databases
InterPro	IPR000866. Alkyl_hydroperoxide_Rdtase. IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BCP_HELPJ

Accession

Primary (citable) accession number: Q9ZMU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)