ID   HCPD_HELPJ              Reviewed;         305 AA.
AC   Q9ZMS0;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   RecName: Full=Putative beta-lactamase HcpD;
DE            EC=3.5.2.6;
DE   AltName: Full=Cysteine-rich protein D;
DE   AltName: Full=Penicillin-binding protein 4;
DE            Short=PBP 4;
DE   Flags: Precursor;
GN   Name=hcpD; OrderedLocusNames=jhp_0148;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: May hydrolyze 6-aminopenicillinic acid and 7-
CC       aminocephalosporanic acid (ACA) derivatives. Binds to penicillin (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hcp beta-lactamase family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD05729.1; -; Genomic_DNA.
DR   PIR; F71968; F71968.
DR   RefSeq; WP_000597796.1; NC_000921.1.
DR   AlphaFoldDB; Q9ZMS0; -.
DR   SMR; Q9ZMS0; -.
DR   KEGG; hpj:jhp_0148; -.
DR   eggNOG; COG0790; Bacteria.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR040239; HcpB-like.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13891:SF1; CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7; 1.
DR   PANTHER; PTHR13891; UNCHARACTERIZED; 1.
DR   Pfam; PF08238; Sel1; 7.
DR   SMART; SM00671; SEL1; 7.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Disulfide bond; Hydrolase; Repeat; Secreted; Signal;
KW   TPR repeat.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           28..305
FT                   /note="Putative beta-lactamase HcpD"
FT                   /id="PRO_0000013199"
FT   REPEAT          28..61
FT                   /note="TPR 1"
FT   REPEAT          96..133
FT                   /note="TPR 2"
FT   REPEAT          168..205
FT                   /note="TPR 3"
FT   REPEAT          240..277
FT                   /note="TPR 4"
FT   DISULFID        55..63
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..99
FT                   /evidence="ECO:0000255"
FT   DISULFID        127..135
FT                   /evidence="ECO:0000255"
FT   DISULFID        163..171
FT                   /evidence="ECO:0000255"
FT   DISULFID        199..207
FT                   /evidence="ECO:0000255"
FT   DISULFID        235..243
FT                   /evidence="ECO:0000255"
FT   DISULFID        271..279
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  33807 MW;  1B969C1EDAD5DEB2 CRC64;
     MIKSWTKKWF LILFLMASCF GHLVATTGEK YFKMANQALK RGDYHRAVAF YKRSCNLRMG
     VGCTSLGSMY EYGDGVDQNI SKAVFYYRRG CNLRNHLACA SLGSMYEDGD GVQKDFPKAI
     YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ NYAKALSFSK YACSLNYGIS CNFVGYMYKS
     AKGVEKDLKK ALANFKRGCH LKDGASCVSL GYLYEAGMDV KQNEEQALNL YKKGCSLKEG
     SGCHNVAVMY YTGKGAPKDL EKATSYYKKG CALGFSGSCK VLEVIGKESD NLQDDAQNDT
     QDSVQ
//