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Q9ZMS0

- HCPD_HELPJ

UniProt

Q9ZMS0 - HCPD_HELPJ

Protein

Putative beta-lactamase HcpD

Gene

hcpD

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. Binds to penicillin By similarity.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-155-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative beta-lactamase HcpD (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich protein D
    Penicillin-binding protein 4
    Short name:
    PBP 4
    Gene namesi
    Name:hcpD
    Ordered Locus Names:jhp_0148
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727PROSITE-ProRule annotationAdd
    BLAST
    Chaini28 – 305278Putative beta-lactamase HcpDPRO_0000013199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 63Sequence Analysis
    Disulfide bondi91 ↔ 99Sequence Analysis
    Disulfide bondi127 ↔ 135Sequence Analysis
    Disulfide bondi163 ↔ 171Sequence Analysis
    Disulfide bondi199 ↔ 207Sequence Analysis
    Disulfide bondi235 ↔ 243Sequence Analysis
    Disulfide bondi271 ↔ 279Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZMS0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 6134TPR 1Add
    BLAST
    Repeati96 – 13338TPR 2Add
    BLAST
    Repeati168 – 20538TPR 3Add
    BLAST
    Repeati240 – 27738TPR 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 4 TPR repeats.Curated

    Keywords - Domaini

    Repeat, Signal, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    KOiK07126.
    OMAiMYEDGDG.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF08238. Sel1. 7 hits.
    [Graphical view]
    SMARTiSM00671. SEL1. 7 hits.
    [Graphical view]
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZMS0-1 [UniParc]FASTAAdd to Basket

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    MIKSWTKKWF LILFLMASCF GHLVATTGEK YFKMANQALK RGDYHRAVAF    50
    YKRSCNLRMG VGCTSLGSMY EYGDGVDQNI SKAVFYYRRG CNLRNHLACA 100
    SLGSMYEDGD GVQKDFPKAI YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ 150
    NYAKALSFSK YACSLNYGIS CNFVGYMYKS AKGVEKDLKK ALANFKRGCH 200
    LKDGASCVSL GYLYEAGMDV KQNEEQALNL YKKGCSLKEG SGCHNVAVMY 250
    YTGKGAPKDL EKATSYYKKG CALGFSGSCK VLEVIGKESD NLQDDAQNDT 300
    QDSVQ 305
    Length:305
    Mass (Da):33,807
    Last modified:May 1, 1999 - v1
    Checksum:i1B969C1EDAD5DEB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05729.1.
    PIRiF71968.
    RefSeqiNP_222869.1. NC_000921.1.
    WP_000597796.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD05729; AAD05729; jhp_0148.
    GeneIDi889026.
    KEGGihpj:jhp0148.
    PATRICi20604912. VBIHelPyl98156_0168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05729.1 .
    PIRi F71968.
    RefSeqi NP_222869.1. NC_000921.1.
    WP_000597796.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZMS0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD05729 ; AAD05729 ; jhp_0148 .
    GeneIDi 889026.
    KEGGi hpj:jhp0148.
    PATRICi 20604912. VBIHelPyl98156_0168.

    Phylogenomic databases

    eggNOGi COG0790.
    KOi K07126.
    OMAi MYEDGDG.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-155-MONOMER.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF08238. Sel1. 7 hits.
    [Graphical view ]
    SMARTi SM00671. SEL1. 7 hits.
    [Graphical view ]
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiHCPD_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZMS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3