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Protein

Putative beta-lactamase HcpD

Gene

hcpD

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. Binds to penicillin (By similarity).By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpD (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein D
Penicillin-binding protein 4
Short name:
PBP 4
Gene namesi
Name:hcpD
Ordered Locus Names:jhp_0148
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804 Componenti: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727PROSITE-ProRule annotationAdd
BLAST
Chaini28 – 305278Putative beta-lactamase HcpDPRO_0000013199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 63Sequence Analysis
Disulfide bondi91 ↔ 99Sequence Analysis
Disulfide bondi127 ↔ 135Sequence Analysis
Disulfide bondi163 ↔ 171Sequence Analysis
Disulfide bondi199 ↔ 207Sequence Analysis
Disulfide bondi235 ↔ 243Sequence Analysis
Disulfide bondi271 ↔ 279Sequence Analysis

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ9ZMS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6134TPR 1Add
BLAST
Repeati96 – 13338TPR 2Add
BLAST
Repeati168 – 20538TPR 3Add
BLAST
Repeati240 – 27738TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiQNDTQDS.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZMS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKSWTKKWF LILFLMASCF GHLVATTGEK YFKMANQALK RGDYHRAVAF
60 70 80 90 100
YKRSCNLRMG VGCTSLGSMY EYGDGVDQNI SKAVFYYRRG CNLRNHLACA
110 120 130 140 150
SLGSMYEDGD GVQKDFPKAI YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ
160 170 180 190 200
NYAKALSFSK YACSLNYGIS CNFVGYMYKS AKGVEKDLKK ALANFKRGCH
210 220 230 240 250
LKDGASCVSL GYLYEAGMDV KQNEEQALNL YKKGCSLKEG SGCHNVAVMY
260 270 280 290 300
YTGKGAPKDL EKATSYYKKG CALGFSGSCK VLEVIGKESD NLQDDAQNDT

QDSVQ
Length:305
Mass (Da):33,807
Last modified:April 30, 1999 - v1
Checksum:i1B969C1EDAD5DEB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05729.1.
PIRiF71968.
RefSeqiNP_222869.1. NC_000921.1.
WP_000597796.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05729; AAD05729; jhp_0148.
KEGGihpj:jhp0148.
PATRICi20604912. VBIHelPyl98156_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05729.1.
PIRiF71968.
RefSeqiNP_222869.1. NC_000921.1.
WP_000597796.1. NC_000921.1.

3D structure databases

ProteinModelPortaliQ9ZMS0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD05729; AAD05729; jhp_0148.
KEGGihpj:jhp0148.
PATRICi20604912. VBIHelPyl98156_0168.

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiQNDTQDS.
OrthoDBiEOG6TJ7WZ.

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-155-MONOMER.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPD_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2003
Last sequence update: April 30, 1999
Last modified: March 31, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.