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Q9ZMS0

- HCPD_HELPJ

UniProt

Q9ZMS0 - HCPD_HELPJ

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Protein
Putative beta-lactamase HcpD
Gene
hcpD, jhp_0148
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. Binds to penicillin By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpD (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein D
Penicillin-binding protein 4
Short name:
PBP 4
Gene namesi
Name:hcpD
Ordered Locus Names:jhp_0148
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 305278Putative beta-lactamase HcpD
PRO_0000013199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 63 Reviewed prediction
Disulfide bondi91 ↔ 99 Reviewed prediction
Disulfide bondi127 ↔ 135 Reviewed prediction
Disulfide bondi163 ↔ 171 Reviewed prediction
Disulfide bondi199 ↔ 207 Reviewed prediction
Disulfide bondi235 ↔ 243 Reviewed prediction
Disulfide bondi271 ↔ 279 Reviewed prediction

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ9ZMS0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6134TPR 1
Add
BLAST
Repeati96 – 13338TPR 2
Add
BLAST
Repeati168 – 20538TPR 3
Add
BLAST
Repeati240 – 27738TPR 4
Add
BLAST

Sequence similaritiesi

Contains 4 TPR repeats.

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiMYEDGDG.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
[Graphical view]
SMARTiSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZMS0-1 [UniParc]FASTAAdd to Basket

« Hide

MIKSWTKKWF LILFLMASCF GHLVATTGEK YFKMANQALK RGDYHRAVAF    50
YKRSCNLRMG VGCTSLGSMY EYGDGVDQNI SKAVFYYRRG CNLRNHLACA 100
SLGSMYEDGD GVQKDFPKAI YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ 150
NYAKALSFSK YACSLNYGIS CNFVGYMYKS AKGVEKDLKK ALANFKRGCH 200
LKDGASCVSL GYLYEAGMDV KQNEEQALNL YKKGCSLKEG SGCHNVAVMY 250
YTGKGAPKDL EKATSYYKKG CALGFSGSCK VLEVIGKESD NLQDDAQNDT 300
QDSVQ 305
Length:305
Mass (Da):33,807
Last modified:May 1, 1999 - v1
Checksum:i1B969C1EDAD5DEB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05729.1.
PIRiF71968.
RefSeqiNP_222869.1. NC_000921.1.
WP_000597796.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05729; AAD05729; jhp_0148.
GeneIDi889026.
KEGGihpj:jhp0148.
PATRICi20604912. VBIHelPyl98156_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05729.1 .
PIRi F71968.
RefSeqi NP_222869.1. NC_000921.1.
WP_000597796.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMS0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05729 ; AAD05729 ; jhp_0148 .
GeneIDi 889026.
KEGGi hpj:jhp0148.
PATRICi 20604912. VBIHelPyl98156_0168.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi MYEDGDG.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-155-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF08238. Sel1. 7 hits.
[Graphical view ]
SMARTi SM00671. SEL1. 7 hits.
[Graphical view ]
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPD_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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