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Q9ZMS0 (HCPD_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-lactamase HcpD

EC=3.5.2.6
Alternative name(s):
Cysteine-rich protein D
Penicillin-binding protein 4
Short name=PBP 4
Gene names
Name:hcpD
Ordered Locus Names:jhp_0148
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. Binds to penicillin By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 4 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 305278Putative beta-lactamase HcpD
PRO_0000013199

Regions

Repeat28 – 6134TPR 1
Repeat96 – 13338TPR 2
Repeat168 – 20538TPR 3
Repeat240 – 27738TPR 4

Amino acid modifications

Disulfide bond55 ↔ 63 Potential
Disulfide bond91 ↔ 99 Potential
Disulfide bond127 ↔ 135 Potential
Disulfide bond163 ↔ 171 Potential
Disulfide bond199 ↔ 207 Potential
Disulfide bond235 ↔ 243 Potential
Disulfide bond271 ↔ 279 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZMS0 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1B969C1EDAD5DEB2

FASTA30533,807
        10         20         30         40         50         60 
MIKSWTKKWF LILFLMASCF GHLVATTGEK YFKMANQALK RGDYHRAVAF YKRSCNLRMG 

        70         80         90        100        110        120 
VGCTSLGSMY EYGDGVDQNI SKAVFYYRRG CNLRNHLACA SLGSMYEDGD GVQKDFPKAI 

       130        140        150        160        170        180 
YYYRRGCHLK GGVSCGSLGF MYFNGTGVKQ NYAKALSFSK YACSLNYGIS CNFVGYMYKS 

       190        200        210        220        230        240 
AKGVEKDLKK ALANFKRGCH LKDGASCVSL GYLYEAGMDV KQNEEQALNL YKKGCSLKEG 

       250        260        270        280        290        300 
SGCHNVAVMY YTGKGAPKDL EKATSYYKKG CALGFSGSCK VLEVIGKESD NLQDDAQNDT 


QDSVQ 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD05729.1.
PIRF71968.
RefSeqNP_222869.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZMS0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD05729; AAD05729; jhp_0148.
GeneID889026.
KEGGhpj:jhp0148.
PATRIC20604912. VBIHelPyl98156_0168.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAANFKRGC.
OrthoDBEOG6TJ7WZ.
ProtClustDBCLSK495893.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-155-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF08238. Sel1. 7 hits.
[Graphical view]
SMARTSM00671. SEL1. 7 hits.
[Graphical view]
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCPD_HELPJ
AccessionPrimary (citable) accession number: Q9ZMS0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families