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Q9ZMR8

- HEM2_HELPJ

UniProt

Q9ZMR8 - HEM2_HELPJ

Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.By similarity

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.

    Cofactori

    Binds 1 zinc ion per monomer.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi118 – 1181Zinc; catalyticBy similarity
    Metal bindingi120 – 1201Zinc; catalyticBy similarity
    Metal bindingi128 – 1281Zinc; catalyticBy similarity
    Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
    Binding sitei203 – 2031Substrate 1By similarity
    Binding sitei215 – 2151Substrate 1By similarity
    Metal bindingi231 – 2311MagnesiumBy similarity
    Active sitei246 – 2461Schiff-base intermediate with substrateBy similarity
    Binding sitei272 – 2721Substrate 2By similarity
    Binding sitei311 – 3111Substrate 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-157-MONOMER.
    UniPathwayiUPA00251; UER00318.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
    Short name:
    ALAD
    Short name:
    ALADH
    Alternative name(s):
    Porphobilinogen synthase
    Gene namesi
    Name:hemB
    Ordered Locus Names:jhp_0150
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Delta-aminolevulinic acid dehydratasePRO_0000140503Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi85963.jhp0150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZMR8.
    SMRiQ9ZMR8. Positions 1-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.Curated

    Phylogenomic databases

    eggNOGiCOG0113.
    KOiK01698.
    OMAiQMNPANR.
    OrthoDBiEOG6VXFCB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZMR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKRLRRLRS SENLRAMVRE TRLNINDFIA PLFVIESDSG IKNEISSMPG    50
    VYQMSIEPLL KECEELVGLG IKAVLLFGIP KHKDATGSHA LNKDHIVAKA 100
    TREIKKRFKD LIVIADLCFC EYTDHGHCGI LENASVSNDK TLKILNLQGL 150
    ILAESGVDIL APSNMMDGNV LSLRKALDKA GYFHTPIMSY STKFASSYYG 200
    PFRDVANSPP SFGDRKSYQM DYANQKEALL ESLEDEKQGA DILMVKPALA 250
    YLDIVKEIRD HTLLPLALYN VSGEYAMLKL AQKHNLINYE SVLLETMTCF 300
    KRAGADMIIS YHAKEVANLL QRN 323
    Length:323
    Mass (Da):36,251
    Last modified:May 1, 1999 - v1
    Checksum:i06938C45FE367F12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05731.1.
    PIRiH71968.
    RefSeqiNP_222871.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD05731; AAD05731; jhp_0150.
    GeneIDi889168.
    KEGGihpj:jhp0150.
    PATRICi20604918. VBIHelPyl98156_0171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05731.1 .
    PIRi H71968.
    RefSeqi NP_222871.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZMR8.
    SMRi Q9ZMR8. Positions 1-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp0150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD05731 ; AAD05731 ; jhp_0150 .
    GeneIDi 889168.
    KEGGi hpj:jhp0150.
    PATRICi 20604918. VBIHelPyl98156_0171.

    Phylogenomic databases

    eggNOGi COG0113.
    KOi K01698.
    OMAi QMNPANR.
    OrthoDBi EOG6VXFCB.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00318 .
    BioCyci HPYL85963:GJB9-157-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiHEM2_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZMR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3