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Q9ZMR8

- HEM2_HELPJ

UniProt

Q9ZMR8 - HEM2_HELPJ

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Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).By similarity

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Binds 1 zinc ion per monomer.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi118 – 1181Zinc; catalyticBy similarity
Metal bindingi120 – 1201Zinc; catalyticBy similarity
Metal bindingi128 – 1281Zinc; catalyticBy similarity
Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
Binding sitei203 – 2031Substrate 1By similarity
Binding sitei215 – 2151Substrate 1By similarity
Metal bindingi231 – 2311MagnesiumBy similarity
Active sitei246 – 2461Schiff-base intermediate with substrateBy similarity
Binding sitei272 – 2721Substrate 2By similarity
Binding sitei311 – 3111Substrate 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-157-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:jhp_0150
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Delta-aminolevulinic acid dehydratasePRO_0000140503Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi85963.jhp0150.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMR8.
SMRiQ9ZMR8. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.Curated

Phylogenomic databases

eggNOGiCOG0113.
KOiK01698.
OMAiQMNPANR.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZMR8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKRLRRLRS SENLRAMVRE TRLNINDFIA PLFVIESDSG IKNEISSMPG
60 70 80 90 100
VYQMSIEPLL KECEELVGLG IKAVLLFGIP KHKDATGSHA LNKDHIVAKA
110 120 130 140 150
TREIKKRFKD LIVIADLCFC EYTDHGHCGI LENASVSNDK TLKILNLQGL
160 170 180 190 200
ILAESGVDIL APSNMMDGNV LSLRKALDKA GYFHTPIMSY STKFASSYYG
210 220 230 240 250
PFRDVANSPP SFGDRKSYQM DYANQKEALL ESLEDEKQGA DILMVKPALA
260 270 280 290 300
YLDIVKEIRD HTLLPLALYN VSGEYAMLKL AQKHNLINYE SVLLETMTCF
310 320
KRAGADMIIS YHAKEVANLL QRN
Length:323
Mass (Da):36,251
Last modified:May 1, 1999 - v1
Checksum:i06938C45FE367F12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05731.1.
PIRiH71968.
RefSeqiNP_222871.1. NC_000921.1.
WP_000476631.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05731; AAD05731; jhp_0150.
GeneIDi889168.
KEGGihpj:jhp0150.
PATRICi20604918. VBIHelPyl98156_0171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05731.1 .
PIRi H71968.
RefSeqi NP_222871.1. NC_000921.1.
WP_000476631.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMR8.
SMRi Q9ZMR8. Positions 1-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05731 ; AAD05731 ; jhp_0150 .
GeneIDi 889168.
KEGGi hpj:jhp0150.
PATRICi 20604918. VBIHelPyl98156_0171.

Phylogenomic databases

eggNOGi COG0113.
KOi K01698.
OMAi QMNPANR.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci HPYL85963:GJB9-157-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHEM2_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3