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Q9ZMQ6

- ALF_HELPJ

UniProt

Q9ZMQ6 - ALF_HELPJ

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Protein
Fructose-bisphosphate aldolase
Gene
fba, jhp_0162
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Glyceraldehyde 3-phosphate By similarity
Active sitei82 – 821Proton donor By similarity
Metal bindingi83 – 831Zinc 1; catalytic By similarity
Metal bindingi104 – 1041Zinc 2 By similarity
Metal bindingi134 – 1341Zinc 2 By similarity
Metal bindingi180 – 1801Zinc 1; catalytic By similarity
Binding sitei181 – 1811Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi210 – 2101Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-169-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:jhp_0162
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Fructose-bisphosphate aldolase
PRO_0000178718Add
BLAST

Proteomic databases

PRIDEiQ9ZMQ6.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi85963.jhp0162.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMQ6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni211 – 2133Dihydroxyacetone phosphate binding By similarity
Regioni253 – 2564Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiCTTRYEA.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZMQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MLVKGNEILL KAHKEGYGVG AFNFVNFEML NAIFEAGNEE NSPLFIQASE    50
GAIKYMGIDM AVGMVKIMCE RYPHIPVALH LDHGTTFESC EKAVKAGFTS 100
VMIDASHHAF EENLELTSKV VKMAHNAGVS VEAELGRLMG IEDNISVDEK 150
DAVLVNPKEA ERFVKESQVD YLAPAIGTSH GAFKFKGEPK LDFERLQEVK 200
RLTNIPLVLH GASAIPDDVR KSYLDAGGDL KGSKGVPFEF LQESIKGGIN 250
KVNTDTDLRI AFIAEVRKVA NEDKSQFDLR KFFSPAQLAL KNVVKERMKL 300
LGSANKI 307
Length:307
Mass (Da):33,798
Last modified:May 1, 1999 - v1
Checksum:i183D55744097E248
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05734.1.
PIRiC71967.
RefSeqiNP_222883.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05734; AAD05734; jhp_0162.
GeneIDi889011.
KEGGihpj:jhp0162.
PATRICi20604944. VBIHelPyl98156_0184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05734.1 .
PIRi C71967.
RefSeqi NP_222883.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMQ6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85963.jhp0162.

Proteomic databases

PRIDEi Q9ZMQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05734 ; AAD05734 ; jhp_0162 .
GeneIDi 889011.
KEGGi hpj:jhp0162.
PATRICi 20604944. VBIHelPyl98156_0184.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi CTTRYEA.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci HPYL85963:GJB9-169-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiALF_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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