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Q9ZMP1

- FRDB_HELPJ

UniProt

Q9ZMP1 - FRDB_HELPJ

Protein

Fumarate reductase iron-sulfur subunit

Gene

frdB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi68 – 681Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi160 – 1601Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi164 – 1641Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi211 – 2111Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi217 – 2171Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi221 – 2211Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-184-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
    Gene namesi
    Name:frdB
    Ordered Locus Names:jhp_0177
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Fumarate reductase iron-sulfur subunitPRO_0000158704Add
    BLAST

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556.By similarity

    Protein-protein interaction databases

    IntActiQ9ZMP1. 1 interaction.
    STRINGi85963.jhp0177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZMP1.
    SMRiQ9ZMP1. Positions 6-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 98822Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini145 – 174304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0479.
    KOiK00245.
    OMAiFMIDPHD.
    OrthoDBiEOG6CS02W.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZMP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDNERTIVV RVLKFDPQSA VNKPHFKEYQ LKETPSMTLF IALNLIREHQ    50
    DPDLSFDFVC RAGICGSCAM MVNGRPRLAC KTLTSSFENG VITLMPMPSF 100
    TLIKDLSVNT GDWFSDMTKR VESWAHSKEE VDITKPEKRV EPDEAQEVFE 150
    LDRCIECGCC IASCGTKLMR PNFIGAAGMN RAMRFMIDSH DERSDDDFYE 200
    LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK VGKSR 245
    Length:245
    Mass (Da):27,625
    Last modified:May 1, 1999 - v1
    Checksum:iD400D302E279DB4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05761.1.
    PIRiF71963.
    RefSeqiNP_222898.1. NC_000921.1.
    WP_001282415.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD05761; AAD05761; jhp_0177.
    GeneIDi889211.
    KEGGihpj:jhp0177.
    PATRICi20604976. VBIHelPyl98156_0200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05761.1 .
    PIRi F71963.
    RefSeqi NP_222898.1. NC_000921.1.
    WP_001282415.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZMP1.
    SMRi Q9ZMP1. Positions 6-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ZMP1. 1 interaction.
    STRINGi 85963.jhp0177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD05761 ; AAD05761 ; jhp_0177 .
    GeneIDi 889211.
    KEGGi hpj:jhp0177.
    PATRICi 20604976. VBIHelPyl98156_0200.

    Phylogenomic databases

    eggNOGi COG0479.
    KOi K00245.
    OMAi FMIDPHD.
    OrthoDBi EOG6CS02W.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-184-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiFRDB_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZMP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3