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Q9ZMP1

- FRDB_HELPJ

UniProt

Q9ZMP1 - FRDB_HELPJ

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Protein
Fumarate reductase iron-sulfur subunit
Gene
frdB, jhp_0177
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi68 – 681Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi160 – 1601Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi164 – 1641Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi211 – 2111Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi217 – 2171Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi221 – 2211Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-184-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:frdB
Ordered Locus Names:jhp_0177
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Fumarate reductase iron-sulfur subunit
PRO_0000158704Add
BLAST

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.

Protein-protein interaction databases

IntActiQ9ZMP1. 1 interaction.
STRINGi85963.jhp0177.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMP1.
SMRiQ9ZMP1. Positions 6-241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 98822Fe-2S ferredoxin-type
Add
BLAST
Domaini145 – 174304Fe-4S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0479.
KOiK00245.
OMAiFMIDPHD.
OrthoDBiEOG6CS02W.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZMP1-1 [UniParc]FASTAAdd to Basket

« Hide

MSDNERTIVV RVLKFDPQSA VNKPHFKEYQ LKETPSMTLF IALNLIREHQ    50
DPDLSFDFVC RAGICGSCAM MVNGRPRLAC KTLTSSFENG VITLMPMPSF 100
TLIKDLSVNT GDWFSDMTKR VESWAHSKEE VDITKPEKRV EPDEAQEVFE 150
LDRCIECGCC IASCGTKLMR PNFIGAAGMN RAMRFMIDSH DERSDDDFYE 200
LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK VGKSR 245
Length:245
Mass (Da):27,625
Last modified:May 1, 1999 - v1
Checksum:iD400D302E279DB4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05761.1.
PIRiF71963.
RefSeqiNP_222898.1. NC_000921.1.
WP_001282415.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05761; AAD05761; jhp_0177.
GeneIDi889211.
KEGGihpj:jhp0177.
PATRICi20604976. VBIHelPyl98156_0200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05761.1 .
PIRi F71963.
RefSeqi NP_222898.1. NC_000921.1.
WP_001282415.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMP1.
SMRi Q9ZMP1. Positions 6-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ZMP1. 1 interaction.
STRINGi 85963.jhp0177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05761 ; AAD05761 ; jhp_0177 .
GeneIDi 889211.
KEGGi hpj:jhp0177.
PATRICi 20604976. VBIHelPyl98156_0200.

Phylogenomic databases

eggNOGi COG0479.
KOi K00245.
OMAi FMIDPHD.
OrthoDBi EOG6CS02W.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-184-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiFRDB_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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