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Protein

Fumarate reductase iron-sulfur subunit

Gene

frdB

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi65 – 651Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi68 – 681Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi160 – 1601Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi164 – 1641Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi211 – 2111Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi217 – 2171Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi221 – 2211Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-184-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:frdB
Ordered Locus Names:jhp_0177
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Fumarate reductase iron-sulfur subunitPRO_0000158704Add
BLAST

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556.By similarity

Protein-protein interaction databases

IntActiQ9ZMP1. 1 interaction.
STRINGi85963.jhp0177.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMP1.
SMRiQ9ZMP1. Positions 6-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 98822Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini145 – 174304Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0479.
KOiK00245.
OMAiNTGDWFL.
OrthoDBiEOG6CS02W.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZMP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNERTIVV RVLKFDPQSA VNKPHFKEYQ LKETPSMTLF IALNLIREHQ
60 70 80 90 100
DPDLSFDFVC RAGICGSCAM MVNGRPRLAC KTLTSSFENG VITLMPMPSF
110 120 130 140 150
TLIKDLSVNT GDWFSDMTKR VESWAHSKEE VDITKPEKRV EPDEAQEVFE
160 170 180 190 200
LDRCIECGCC IASCGTKLMR PNFIGAAGMN RAMRFMIDSH DERSDDDFYE
210 220 230 240
LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK VGKSR
Length:245
Mass (Da):27,625
Last modified:April 30, 1999 - v1
Checksum:iD400D302E279DB4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05761.1.
PIRiF71963.
RefSeqiNP_222898.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05761; AAD05761; jhp_0177.
KEGGihpj:jhp0177.
PATRICi20604976. VBIHelPyl98156_0200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05761.1.
PIRiF71963.
RefSeqiNP_222898.1. NC_000921.1.

3D structure databases

ProteinModelPortaliQ9ZMP1.
SMRiQ9ZMP1. Positions 6-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ZMP1. 1 interaction.
STRINGi85963.jhp0177.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD05761; AAD05761; jhp_0177.
KEGGihpj:jhp0177.
PATRICi20604976. VBIHelPyl98156_0200.

Phylogenomic databases

eggNOGiCOG0479.
KOiK00245.
OMAiNTGDWFL.
OrthoDBiEOG6CS02W.

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-184-MONOMER.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiFRDB_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2001
Last sequence update: April 30, 1999
Last modified: March 31, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.