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Q9ZMP1 (FRDB_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate reductase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:frdB
Ordered Locus Names:jhp_0177
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Subunit structure

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Fumarate reductase iron-sulfur subunit
PRO_0000158704

Regions

Domain17 – 98822Fe-2S ferredoxin-type
Domain145 – 174304Fe-4S ferredoxin-type

Sites

Metal binding601Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding651Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding681Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding801Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1541Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1601Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1641Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2111Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2171Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2211Iron-sulfur 2 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZMP1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D400D302E279DB4B

FASTA24527,625
        10         20         30         40         50         60 
MSDNERTIVV RVLKFDPQSA VNKPHFKEYQ LKETPSMTLF IALNLIREHQ DPDLSFDFVC 

        70         80         90        100        110        120 
RAGICGSCAM MVNGRPRLAC KTLTSSFENG VITLMPMPSF TLIKDLSVNT GDWFSDMTKR 

       130        140        150        160        170        180 
VESWAHSKEE VDITKPEKRV EPDEAQEVFE LDRCIECGCC IASCGTKLMR PNFIGAAGMN 

       190        200        210        220        230        240 
RAMRFMIDSH DERSDDDFYE LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK 


VGKSR 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD05761.1.
PIRF71963.
RefSeqNP_222898.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZMP1.
SMRQ9ZMP1. Positions 6-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9ZMP1. 1 interaction.
STRING85963.jhp0177.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD05761; AAD05761; jhp_0177.
GeneID889211.
KEGGhpj:jhp0177.
PATRIC20604976. VBIHelPyl98156_0200.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0479.
KOK00245.
OMAFMIDPHD.
OrthoDBEOG6CS02W.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-184-MONOMER.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRDB_HELPJ
AccessionPrimary (citable) accession number: Q9ZMP1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families