Reviewed, UniProtKB/Swiss-Prot Q9ZMP0 (FRDA_HELPJ)

Names and origin

Protein names

Recommended name:
    Fumarate reductase flavoprotein subunit
    EC=1.3.99.1

Gene names

Name:	frdA
Ordered Locus Names:	jhp_0178

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	714 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 FAD covalently per subunit By similarity.
Subunit structure	Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 By similarity.
Sequence similarities	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 714	714	Fumarate reductase flavoprotein subunit		PRO_0000158663
Regions
	Nucleotide binding	9 – 23	15	FAD Potential
Sites
	Active site	257	1	By similarity
	Active site	273	1	By similarity
Amino acid modifications
	Modified residue	43	1	Tele-8alpha-FAD histidine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZMP0-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: CE6F1041EDAEC977	FASTA	714	80,120
	10 20 30 40 50 60 MKITYCDALI IGGGLAGLRA SIACKQKGLN TIVLSLVPVR RSHSAAAQGG MQASLANAKK 70 80 90 100 110 120 SEGDNEDLHF LDTVKGSDWG CDQQVARMFV TTAPKAIREL ASWGVPWTRI KKGDRPAVVN 130 140 150 160 170 180 GEHVIITERD DRHGYILSRD FGGTKKWRTC FTADATGHTM LYAVANEALH HKVDIQDRKD 190 200 210 220 230 240 MLAFIHHDNK CYGAVVRDLI TGEISAYVSK GTLLATGGYG RVYKHTTNAV ICDGAGAASA 250 260 270 280 290 300 LETGVAKLGN MEAVQFHPTA LVPSGILMTE GCRGDGGVLR DKFGRRFMPA YEPEKKELAS 310 320 330 340 350 360 RDVVSRRILE HIQKGYGAKS PYGDHVWLDI AILGRNHVEK NLRDVRDIAM TFAGIDPADS 370 380 390 400 410 420 EEQTKDNMQG APTNEPEYGQ AMAKQKGWIP IKPMQHYSMG GVRTNPKGET HLKGLFCAGE 430 440 450 460 470 480 AACWDLHGFN RLGGNSVSEP VVAGMIIGDY FASHCLEAQI EINTQKVEAF IKESQDYMHF 490 500 510 520 530 540 LLHNEGKEDV YEIRERMKEV MDEKVGVFRE GKKLEEALKE LQELYARSKN ICVKNKVLHN 550 560 570 580 590 600 NPELEDAYRT KKMLKLALCI TQGALLRTES RGAHTRIDYP KRDDEKWLNR TLASWPSAEQ 610 620 630 640 650 660 DMPTIEYEEL DVMKMEISPD FRGYGKKGNF IPHPKKEERD AEILKTILEL EKLGKDRIEV 670 680 690 700 710 QHALMPFELQ EKYKARNMRL EDEEVRARGE HLYSFNVHDL LDQHNANLKG EHHE

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05762.1.
PIR	G71963.
RefSeq	NP_222899.1.
3D structure databases
HSSP	HSSP built from PDB template 1QLA based on UniProtKB P17412.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ZMP0. 1 interaction.
Proteomic databases
PRIDE	Q9ZMP0.
Genome annotation databases
GeneID	889257.
GenomeReviews	Gene locus jhp_0178 in contig AE001439_GR.
KEGG	hpj:jhp0178.
NMPDR	fig|85963.1.peg.177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZMP0.
OMA	Q9ZMP0. DATGHTM.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0178-MON.
BRENDA	1.3.99.1. 295085.
Family and domain databases
InterPro	IPR003953. FAD_bind2_N. IPR003952. FRD_SDH_FAD_BS. IPR004112. Fum_Rdtase/Succ_DH_flav_C. IPR014006. Succ_Dhase_frdA_Gneg. [Graphical view]
Pfam	PF00890. FAD_binding_2. 1 hit. PF02910. Succ_DH_flav_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITE	PS00504. FRD_SDH_FAD_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRDA_HELPJ

Accession

Primary (citable) accession number: Q9ZMP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)