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Q9ZMM1

- HCPA_HELPJ

UniProt

Q9ZMM1 - HCPA_HELPJ

Protein

Beta-lactamase HcpA

Gene

hcpA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Slowly hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. May be involved in the synthesis of the cell wall peptidoglycan By similarity.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Enzyme regulationi

    Inhibited by cloxacillin and oxacillin but not by ACA derivatives or metal chelators.By similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-204-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase HcpA (EC:3.5.2.6)
    Alternative name(s):
    Cysteine-rich 28 kDa protein
    Gene namesi
    Name:hcpA
    Ordered Locus Names:jhp_0197
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 250225Beta-lactamase HcpAPRO_0000013195Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 64By similarity
    Disulfide bondi92 ↔ 100By similarity
    Disulfide bondi128 ↔ 136By similarity
    Disulfide bondi164 ↔ 172By similarity
    Disulfide bondi196 ↔ 204By similarity
    Disulfide bondi232 ↔ 240By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi85963.jhp0197.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ZMM1.
    SMRiQ9ZMM1. Positions 28-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 6234TPR 1Add
    BLAST
    Repeati67 – 9832TPR 2Add
    BLAST
    Repeati100 – 13334TPR 3Add
    BLAST
    Repeati134 – 16936TPR 4Add
    BLAST
    Repeati170 – 20233TPR 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 5 TPR repeats.Curated

    Keywords - Domaini

    Repeat, Signal, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    KOiK07126.
    OMAiIKCAFTI.
    OrthoDBiEOG6TJ7WZ.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    [Graphical view]
    PfamiPF08238. Sel1. 5 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view]
    SMARTiSM00671. SEL1. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ZMM1-1 [UniParc]FASTAAdd to Basket

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    MLGSVKKTLF GVLCLGALCL RGLMAEPDAK ELVSLGIESV KKQDFAQAKA    50
    HFEKACELKE GFGCVFLGAF YEEGKGVGKD LKKAIQFYTK GCELNDGYGC 100
    RLLGNLYYNG QGVSKDAKKA SQYYSKSCEL NHAEGCTVLG SLHHYGVGTP 150
    KDLRKALDLY EKACDLKDSP GCINAGYMYG VAKNFKEAIV RYSKACELKD 200
    GRGCYNLGVM QYNAQGTAKD EKQAVENFKK GCKSSVKEAC DALKELKIEL 250
    Length:250
    Mass (Da):27,295
    Last modified:May 1, 1999 - v1
    Checksum:i94EC37877E98C578
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05781.1.
    PIRiB71961.
    RefSeqiNP_222918.1. NC_000921.1.
    WP_000901652.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD05781; AAD05781; jhp_0197.
    GeneIDi889172.
    KEGGihpj:jhp0197.
    PATRICi20605018. VBIHelPyl98156_0221.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD05781.1 .
    PIRi B71961.
    RefSeqi NP_222918.1. NC_000921.1.
    WP_000901652.1. NC_000921.1.

    3D structure databases

    ProteinModelPortali Q9ZMM1.
    SMRi Q9ZMM1. Positions 28-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85963.jhp0197.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD05781 ; AAD05781 ; jhp_0197 .
    GeneIDi 889172.
    KEGGi hpj:jhp0197.
    PATRICi 20605018. VBIHelPyl98156_0221.

    Phylogenomic databases

    eggNOGi COG0790.
    KOi K07126.
    OMAi IKCAFTI.
    OrthoDBi EOG6TJ7WZ.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-204-MONOMER.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    IPR013105. TPR_2.
    [Graphical view ]
    Pfami PF08238. Sel1. 5 hits.
    PF07719. TPR_2. 1 hit.
    [Graphical view ]
    SMARTi SM00671. SEL1. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiHCPA_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZMM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3