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Q9ZMM1 (HCPA_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase HcpA

EC=3.5.2.6
Alternative name(s):
Cysteine-rich 28 kDa protein
Gene names
Name:hcpA
Ordered Locus Names:jhp_0197
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Slowly hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. May be involved in the synthesis of the cell wall peptidoglycan By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulation

Inhibited by cloxacillin and oxacillin but not by ACA derivatives or metal chelators By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 5 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 250225Beta-lactamase HcpA
PRO_0000013195

Regions

Repeat29 – 6234TPR 1
Repeat67 – 9832TPR 2
Repeat100 – 13334TPR 3
Repeat134 – 16936TPR 4
Repeat170 – 20233TPR 5

Amino acid modifications

Disulfide bond56 ↔ 64 By similarity
Disulfide bond92 ↔ 100 By similarity
Disulfide bond128 ↔ 136 By similarity
Disulfide bond164 ↔ 172 By similarity
Disulfide bond196 ↔ 204 By similarity
Disulfide bond232 ↔ 240 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZMM1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 94EC37877E98C578

FASTA25027,295
        10         20         30         40         50         60 
MLGSVKKTLF GVLCLGALCL RGLMAEPDAK ELVSLGIESV KKQDFAQAKA HFEKACELKE 

        70         80         90        100        110        120 
GFGCVFLGAF YEEGKGVGKD LKKAIQFYTK GCELNDGYGC RLLGNLYYNG QGVSKDAKKA 

       130        140        150        160        170        180 
SQYYSKSCEL NHAEGCTVLG SLHHYGVGTP KDLRKALDLY EKACDLKDSP GCINAGYMYG 

       190        200        210        220        230        240 
VAKNFKEAIV RYSKACELKD GRGCYNLGVM QYNAQGTAKD EKQAVENFKK GCKSSVKEAC 

       250 
DALKELKIEL 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD05781.1.
PIRB71961.
RefSeqNP_222918.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZMM1.
SMRQ9ZMM1. Positions 28-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85963.jhp0197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD05781; AAD05781; jhp_0197.
GeneID889172.
KEGGhpj:jhp0197.
PATRIC20605018. VBIHelPyl98156_0221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAIKCAFTI.
OrthoDBEOG6TJ7WZ.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-204-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 3 hits.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
[Graphical view]
PfamPF08238. Sel1. 5 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00671. SEL1. 6 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCPA_HELPJ
AccessionPrimary (citable) accession number: Q9ZMM1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families