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Q9ZMM1

- HCPA_HELPJ

UniProt

Q9ZMM1 - HCPA_HELPJ

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Protein

Beta-lactamase HcpA

Gene

hcpA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Slowly hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives. May be involved in the synthesis of the cell wall peptidoglycan (By similarity).By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Enzyme regulationi

Inhibited by cloxacillin and oxacillin but not by ACA derivatives or metal chelators.By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase HcpA (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich 28 kDa protein
Gene namesi
Name:hcpA
Ordered Locus Names:jhp_0197
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 250225Beta-lactamase HcpAPRO_0000013195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 64By similarity
Disulfide bondi92 ↔ 100By similarity
Disulfide bondi128 ↔ 136By similarity
Disulfide bondi164 ↔ 172By similarity
Disulfide bondi196 ↔ 204By similarity
Disulfide bondi232 ↔ 240By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0197.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMM1.
SMRiQ9ZMM1. Positions 28-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 6234TPR 1Add
BLAST
Repeati67 – 9832TPR 2Add
BLAST
Repeati100 – 13334TPR 3Add
BLAST
Repeati134 – 16936TPR 4Add
BLAST
Repeati170 – 20233TPR 5Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 5 TPR repeats.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiIKCAFTI.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZMM1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGSVKKTLF GVLCLGALCL RGLMAEPDAK ELVSLGIESV KKQDFAQAKA
60 70 80 90 100
HFEKACELKE GFGCVFLGAF YEEGKGVGKD LKKAIQFYTK GCELNDGYGC
110 120 130 140 150
RLLGNLYYNG QGVSKDAKKA SQYYSKSCEL NHAEGCTVLG SLHHYGVGTP
160 170 180 190 200
KDLRKALDLY EKACDLKDSP GCINAGYMYG VAKNFKEAIV RYSKACELKD
210 220 230 240 250
GRGCYNLGVM QYNAQGTAKD EKQAVENFKK GCKSSVKEAC DALKELKIEL
Length:250
Mass (Da):27,295
Last modified:May 1, 1999 - v1
Checksum:i94EC37877E98C578
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05781.1.
PIRiB71961.
RefSeqiNP_222918.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05781; AAD05781; jhp_0197.
GeneIDi889172.
KEGGihpj:jhp0197.
PATRICi20605018. VBIHelPyl98156_0221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05781.1 .
PIRi B71961.
RefSeqi NP_222918.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMM1.
SMRi Q9ZMM1. Positions 28-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05781 ; AAD05781 ; jhp_0197 .
GeneIDi 889172.
KEGGi hpj:jhp0197.
PATRICi 20605018. VBIHelPyl98156_0221.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi IKCAFTI.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-204-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
[Graphical view ]
Pfami PF08238. Sel1. 5 hits.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SMARTi SM00671. SEL1. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPA_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3