Reviewed, UniProtKB/Swiss-Prot Q9ZML7 (CDSA_HELPJ)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	jhp_0201

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Phosphatidate cytidylyltransferase		PRO_0000090738
Regions
	Transmembrane	16 – 36	21	Potential
	Transmembrane	52 – 72	21	Potential
	Transmembrane	78 – 98	21	Potential
	Transmembrane	101 – 121	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	164 – 184	21	Potential
	Transmembrane	186 – 206	21	Potential
	Transmembrane	237 – 257	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ZML7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 99C48ED30B45AF45	FASTA	266	28,788
	10 20 30 40 50 60 MKEELFKEKS RYITGVVLIV VAGLILYADN LLLFWAVLGG IYAVGFFEAL RLFQVKASFS 70 80 90 100 110 120 LYLILVLSWV AAYFNGHPVE CALISAMVMA SVIAYQKAHH SEAILPFLYP GVGFFALFGV 130 140 150 160 170 180 YKDFGAVAII WLLVVVVASD VGAFFGGKLL GKTPFTATSP NKTLEGALIG VVLASVLGSF 190 200 210 220 230 240 VGMGKLSGGF LMALLFSFLI ALMAVFGDLY ESYLKRKVGV KDSGKILPGH GGVLDRLDSM 250 260 LFGALSLHVL LYFLEIWKET AVFLGD

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001439 Genomic DNA. Translation: AAD05785.1.
PIR	F71961.
RefSeq	NP_222922.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZML7.
Genome annotation databases
GeneID	889289.
GenomeReviews	Gene locus jhp_0201 in contig AE001439_GR.
KEGG	hpj:jhp0201.
NMPDR	fig|85963.1.peg.200.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9ZML7.
OMA	MAVFGDL.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0201-MON.
BRENDA	2.7.7.41. 295085.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_HELPJ

Accession

Primary (citable) accession number: Q9ZML7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)