Reviewed,
UniProtKB/Swiss-Prot Q9ZMK8 (MSRAB_HELPJ)
Last modified
February 9, 2010.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peptide methionine sulfoxide reductase msrA/msrB Including the following 2 domains: 1- Recommended name: Peptide methionine sulfoxide reductase msrA Short name=Protein-methionine-S-oxide reductase EC=1.8.4.11 Alternative name(s): Peptide-methionine (S)-S-oxide reductase Short name=Peptide Met(O) reductase 2- Recommended name: Peptide methionine sulfoxide reductase msrB EC=1.8.4.12 Alternative name(s): Peptide-methionine (R)-S-oxide reductase | ||||||
| Gene names |
| ||||||
| Organism | Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 85963 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01400 |
| Catalytic activity | Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. |
| Sequence similarities | In the N-terminal section; belongs to the msrA Met sulfoxide reductase family. In the C-terminal section; belongs to the msrB Met sulfoxide reductase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification processInferred from electronic annotation. Source: HAMAP |
| Molecular function | peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | Peptide methionine sulfoxide reductase msrA/msrB HAMAP MF_01400 | PRO_0000138514 | |||||
Regions | |||||||||
| Region | 36 – 189 | 154 | Peptide methionine sulfoxide reductase A HAMAP MF_01400 | ||||||
| Region | 206 – 329 | 124 | Peptide methionine sulfoxide reductase B HAMAP MF_01400 | ||||||
Sites | |||||||||
| Active site | 44 | 1 | By similarity | ||||||
| Active site | 318 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. Trust T.J.Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE001439 Genomic DNA. Translation: AAD05793.1. |
| PIR | E71960. |
| RefSeq | NP_222931.1. |
3D structure databases | |
| SMR | Q9ZMK8. Positions 35-196, 201-338. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9ZMK8. |
Genome annotation databases | |
| GeneID | 889429. |
| GenomeReviews | Gene locus jhp_0210 in contig AE001439_GR. |
| KEGG | hpj:jhp0210. |
| NMPDR | fig|85963.1.peg.209. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0225. |
| HOGENOM | HBG715255. |
| OMA | DERVIYL. |
Enzyme and pathway databases | |
| BioCyc | HPYL85963:JHP0210-MONOMER. |
| BRENDA | 1.8.4.11. 295085. 1.8.4.12. 295085. |
Family and domain databases | |
| HAMAP | MF_01400. MsrB. Fused. [Tree] MF_01401. MsrA. Fused. [Tree] |
| InterPro | IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view] |
| Gene3D | G3DSA:3.30.1060.10. MsrA. 1 hit. G3DSA:2.170.150.20. MsrB. 1 hit. |
| Pfam | PF01625. PMSR. 1 hit. PF01641. SelR. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00401. msrA. 1 hit. TIGR00357. MsrB. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MSRAB_HELPJ | ||||||||
| Accession | Primary (citable) accession number: Q9ZMK8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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