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Q9ZMJ9

- HCPE_HELPJ

UniProt

Q9ZMJ9 - HCPE_HELPJ

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Protein

Putative beta-lactamase HcpE

Gene

hcpE

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpE (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein E
Gene namesi
Name:hcpE
Ordered Locus Names:jhp_0220
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 355333Putative beta-lactamase HcpEPRO_0000013201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 62Sequence Analysis
Disulfide bondi90 ↔ 98Sequence Analysis
Disulfide bondi126 ↔ 134Sequence Analysis
Disulfide bondi160 ↔ 168Sequence Analysis
Disulfide bondi197 ↔ 205Sequence Analysis
Disulfide bondi234 ↔ 242Sequence Analysis
Disulfide bondi270 ↔ 278Sequence Analysis
Disulfide bondi306 ↔ 314Sequence Analysis
Disulfide bondi338 ↔ 346Sequence Analysis

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0220.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 6034TPR 1Add
BLAST
Repeati63 – 9634TPR 2Add
BLAST
Repeati98 – 13134TPR 3Add
BLAST
Repeati132 – 16635TPR 4Add
BLAST
Repeati202 – 24039TPR 5Add
BLAST
Repeati245 – 27531TPR 6Add
BLAST
Repeati276 – 31136TPR 7Add
BLAST
Repeati312 – 34433TPR 8Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 8 TPR repeats.Curated

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiKENAIMI.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZMJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIKILKILV GGLFFLSLNA HLWGKQDNSF LGIGERAYKS GNYSKAASYF
60 70 80 90 100
KKACNDGVSE GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG
110 120 130 140 150
LGGLYDEGLG TAQNYQEAID AYAKACVLKH PESCYNLGII YDRKIKGNAA
160 170 180 190 200
QAVTYYQKSC NFDMAKGCYI LGTAYEKGFL EVKQSNHKAV IYYLKACRLN
210 220 230 240 250
EGQACRALGS LFENGDAGLD EDFEVAFDYL QKACALNNSG GCASLGSMYM
260 270 280 290 300
LGRYVKKDPQ KAFNYFKQAC DMGSAVSCSR MGFMYSQGDT VSKDLRKALD
310 320 330 340 350
NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT

KLRGY
Length:355
Mass (Da):39,320
Last modified:May 1, 1999 - v1
Checksum:i30F140204B9BCA3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05807.1.
PIRiG71958.
RefSeqiNP_222941.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05807; AAD05807; jhp_0220.
GeneIDi889420.
KEGGihpj:jhp0220.
PATRICi20605081. VBIHelPyl98156_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05807.1 .
PIRi G71958.
RefSeqi NP_222941.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85963.jhp0220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05807 ; AAD05807 ; jhp_0220 .
GeneIDi 889420.
KEGGi hpj:jhp0220.
PATRICi 20605081. VBIHelPyl98156_0251.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi KENAIMI.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-228-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
[Graphical view ]
Pfami PF08238. Sel1. 7 hits.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SMARTi SM00671. SEL1. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPE_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3