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Q9ZMJ9

- HCPE_HELPJ

UniProt

Q9ZMJ9 - HCPE_HELPJ

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Protein
Putative beta-lactamase HcpE
Gene
hcpE, jhp_0220
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative beta-lactamase HcpE (EC:3.5.2.6)
Alternative name(s):
Cysteine-rich protein E
Gene namesi
Name:hcpE
Ordered Locus Names:jhp_0220
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804: Chromosome

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 355333Putative beta-lactamase HcpE
PRO_0000013201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 62 Reviewed prediction
Disulfide bondi90 ↔ 98 Reviewed prediction
Disulfide bondi126 ↔ 134 Reviewed prediction
Disulfide bondi160 ↔ 168 Reviewed prediction
Disulfide bondi197 ↔ 205 Reviewed prediction
Disulfide bondi234 ↔ 242 Reviewed prediction
Disulfide bondi270 ↔ 278 Reviewed prediction
Disulfide bondi306 ↔ 314 Reviewed prediction
Disulfide bondi338 ↔ 346 Reviewed prediction

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0220.

Structurei

3D structure databases

ProteinModelPortaliQ9ZMJ9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 6034TPR 1
Add
BLAST
Repeati63 – 9634TPR 2
Add
BLAST
Repeati98 – 13134TPR 3
Add
BLAST
Repeati132 – 16635TPR 4
Add
BLAST
Repeati202 – 24039TPR 5
Add
BLAST
Repeati245 – 27531TPR 6
Add
BLAST
Repeati276 – 31136TPR 7
Add
BLAST
Repeati312 – 34433TPR 8
Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.

Keywords - Domaini

Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiCOG0790.
KOiK07126.
OMAiKENAIMI.
OrthoDBiEOG6TJ7WZ.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
[Graphical view]
PfamiPF08238. Sel1. 7 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZMJ9-1 [UniParc]FASTAAdd to Basket

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MNIKILKILV GGLFFLSLNA HLWGKQDNSF LGIGERAYKS GNYSKAASYF    50
KKACNDGVSE GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG 100
LGGLYDEGLG TAQNYQEAID AYAKACVLKH PESCYNLGII YDRKIKGNAA 150
QAVTYYQKSC NFDMAKGCYI LGTAYEKGFL EVKQSNHKAV IYYLKACRLN 200
EGQACRALGS LFENGDAGLD EDFEVAFDYL QKACALNNSG GCASLGSMYM 250
LGRYVKKDPQ KAFNYFKQAC DMGSAVSCSR MGFMYSQGDT VSKDLRKALD 300
NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT 350
KLRGY 355
Length:355
Mass (Da):39,320
Last modified:May 1, 1999 - v1
Checksum:i30F140204B9BCA3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05807.1.
PIRiG71958.
RefSeqiNP_222941.1. NC_000921.1.
WP_001022031.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD05807; AAD05807; jhp_0220.
GeneIDi889420.
KEGGihpj:jhp0220.
PATRICi20605081. VBIHelPyl98156_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001439 Genomic DNA. Translation: AAD05807.1 .
PIRi G71958.
RefSeqi NP_222941.1. NC_000921.1.
WP_001022031.1. NC_000921.1.

3D structure databases

ProteinModelPortali Q9ZMJ9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 85963.jhp0220.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD05807 ; AAD05807 ; jhp_0220 .
GeneIDi 889420.
KEGGi hpj:jhp0220.
PATRICi 20605081. VBIHelPyl98156_0251.

Phylogenomic databases

eggNOGi COG0790.
KOi K07126.
OMAi KENAIMI.
OrthoDBi EOG6TJ7WZ.

Enzyme and pathway databases

BioCyci HPYL85963:GJB9-228-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
[Graphical view ]
Pfami PF08238. Sel1. 7 hits.
PF07719. TPR_2. 1 hit.
[Graphical view ]
SMARTi SM00671. SEL1. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiHCPE_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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