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Q9ZMJ9 (HCPE_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative beta-lactamase HcpE

EC=3.5.2.6
Alternative name(s):
Cysteine-rich protein E
Gene names
Name:hcpE
Ordered Locus Names:jhp_0220
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May hydrolyze 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the hcp beta-lactamase family.

Contains 8 TPR repeats.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainRepeat
Signal
TPR repeat
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 355333Putative beta-lactamase HcpE
PRO_0000013201

Regions

Repeat27 – 6034TPR 1
Repeat63 – 9634TPR 2
Repeat98 – 13134TPR 3
Repeat132 – 16635TPR 4
Repeat202 – 24039TPR 5
Repeat245 – 27531TPR 6
Repeat276 – 31136TPR 7
Repeat312 – 34433TPR 8

Amino acid modifications

Disulfide bond54 ↔ 62 Potential
Disulfide bond90 ↔ 98 Potential
Disulfide bond126 ↔ 134 Potential
Disulfide bond160 ↔ 168 Potential
Disulfide bond197 ↔ 205 Potential
Disulfide bond234 ↔ 242 Potential
Disulfide bond270 ↔ 278 Potential
Disulfide bond306 ↔ 314 Potential
Disulfide bond338 ↔ 346 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ZMJ9 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 30F140204B9BCA3A

FASTA35539,320
        10         20         30         40         50         60 
MNIKILKILV GGLFFLSLNA HLWGKQDNSF LGIGERAYKS GNYSKAASYF KKACNDGVSE 

        70         80         90        100        110        120 
GCTQLGIIYE NGQGTRIDYK KALEYYKTAC QADDREGCFG LGGLYDEGLG TAQNYQEAID 

       130        140        150        160        170        180 
AYAKACVLKH PESCYNLGII YDRKIKGNAA QAVTYYQKSC NFDMAKGCYI LGTAYEKGFL 

       190        200        210        220        230        240 
EVKQSNHKAV IYYLKACRLN EGQACRALGS LFENGDAGLD EDFEVAFDYL QKACALNNSG 

       250        260        270        280        290        300 
GCASLGSMYM LGRYVKKDPQ KAFNYFKQAC DMGSAVSCSR MGFMYSQGDT VSKDLRKALD 

       310        320        330        340        350 
NYERGCDMGD EVGCFALAGM YYNMKDKENA IMIYDKGCKL GMKQACENLT KLRGY 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD05807.1.
PIRG71958.
RefSeqNP_222941.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZMJ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85963.jhp0220.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD05807; AAD05807; jhp_0220.
GeneID889420.
KEGGhpj:jhp0220.
PATRIC20605081. VBIHelPyl98156_0251.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0790.
KOK07126.
OMAKENAIMI.
OrthoDBEOG6TJ7WZ.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-228-MONOMER.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR006597. Sel1-like.
IPR011990. TPR-like_helical.
IPR013105. TPR_2.
[Graphical view]
PfamPF08238. Sel1. 7 hits.
PF07719. TPR_2. 1 hit.
[Graphical view]
SMARTSM00671. SEL1. 8 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHCPE_HELPJ
AccessionPrimary (citable) accession number: Q9ZMJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families