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Q9ZM69 (COPA_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Copper-transporting ATPase
EC=3.6.3.4
Gene names
Name:copA
Ordered Locus Names:jhp_0353
OrganismHelicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in copper export.

Catalytic activity

ATP + H2O + Cu2+(In) = ADP + phosphate + Cu2+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 1 HMA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 745745Copper-transporting ATPase
PRO_0000046174

Regions

Topological domain1 – 8383Cytoplasmic Potential
Transmembrane84 – 10421Helical; Potential
Topological domain105 – 12420Extracellular Potential
Transmembrane125 – 14420Helical; Potential
Topological domain145 – 1517Cytoplasmic Potential
Transmembrane152 – 17221Helical; Potential
Topological domain173 – 19422Extracellular Potential
Transmembrane195 – 21521Helical; Potential
Topological domain216 – 343128Cytoplasmic Potential
Transmembrane344 – 36623Helical; Potential
Topological domain367 – 37913Extracellular Potential
Transmembrane380 – 39718Helical; Potential
Topological domain398 – 685288Cytoplasmic Potential
Transmembrane686 – 70520Helical; Potential
Topological domain706 – 71611Extracellular Potential
Transmembrane717 – 73519Helical; Potential
Topological domain736 – 74510Cytoplasmic Potential
Domain2 – 6867HMA

Sites

Active site43514-aspartylphosphate intermediate By similarity
Metal binding121Copper Potential
Metal binding151Copper Potential
Metal binding6311Magnesium By similarity
Metal binding6351Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZM69 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 69E5CD155579C59F

FASTA74581,912
        10         20         30         40         50         60 
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFNENET NLDEIFKLIE 

        70         80         90        100        110        120 
KLGYSPKKTL AEEKKEFFSP NVKLALAVIF TLFVVYLSMG AMLSPSLLPE SLLTINHHSN 

       130        140        150        160        170        180 
FLNACLQLIG ALIVMHLGRD FYIQGFKALW HRQPNMSSLI AIGTSAALIS SLWQLYLVYT 

       190        200        210        220        230        240 
NHYTDQWSYG HYYFESVCVI LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMHNNQ 

       250        260        270        280        290        300 
QIEVLVDSIV VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT 

       310        320        330        340        350        360 
LNSNTSFLMK ATQDNKNSTL SQIIEMIHNA QSSKAEISRL ADKVSSVFVP SVIAIAVLAF 

       370        380        390        400        410        420 
VVWLIIAPKP DFWWNFRTAL EVFVSVLVIS CPCALGLATP MSILVANQKA SSLGLFFKDA 

       430        440        450        460        470        480 
KSLEKARLVN TIVFDKTGTL TNGKPVVKSI HSNIELLELL SLASSIEKSS EHVIAKGIVE 

       490        500        510        520        530        540 
YAKERNAPLK DISEVKVKTG FGISAKVDYQ GAKEIIKVGN SEFFNPINTL EIKENGILVF 

       550        560        570        580        590        600 
VGRAINEKED ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VKKCALELGI 

       610        620        630        640        650        660 
DGYISNAKPQ DKLNKIKELK EKGRIVMMVG DGLNDAPSLA MSDVAVVMAK GSDVSVQAAD 

       670        680        690        700        710        720 
IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI PLACGVLYKA NIMLSPAIAG 

       730        740 
LAMSLSSVSV VLNSQRLRNF KIKDH

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001439 Genomic DNA. Translation: AAD05935.1.
PIRA71941.
RefSeqNP_223072.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZM69.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZM69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID889106.
GenomeReviewsGene locus jhp_0353 in contig AE001439_GR.
KEGGhpj:jhp0353.
NMPDRfig|85963.1.peg.350.
PATRIC20605366. VBIHelPyl98156_0391.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2217.
HOGENOMHBG507745.
OMAMHPEVRD.
ProtClustDBCLSK496017.

Enzyme and pathway databases

BioCycHPYL85963:JHP0353-MONOMER.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR006403. ATPase_P-typ_cat/Cu-transptr.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR006416. ATPase_P-typ_heavy-metal.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK01533.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00943. CUATPASE.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
SSF55008. HeavyMe_transpt. 1 hit.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOPA_HELPJ
AccessionPrimary (citable) accession number: Q9ZM69
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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