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Protein

Glutamine synthetase

Gene

glnA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:jhp_0461
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000804 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Glutamine synthetasePRO_0000153240Add
BLAST

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.By similarity

Protein-protein interaction databases

STRINGi85963.jhp0461.

Structurei

3D structure databases

ProteinModelPortaliQ9ZLW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.
OMAiKVLNQVG.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ZLW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVRTQNSES KIKEFFEFCK ENEVEFVDFR FSDIKGTWNH IAYSFGALTH
60 70 80 90 100
DMFKEGIPFD ASSFKGWQGI EHSDMILTPD LVRYFIDPFS ADVSAVVFCD
110 120 130 140 150
VYDVYKNQPY EKCPRSIAKK ALKHLRDLGL GDVAYFGAEN EFFIFDSIKI
160 170 180 190 200
KDASNSQYYE VDSEEGEWNR DKSFENGVNF GHRPGKQGGY MPVPPTDTMM
210 220 230 240 250
DIRTEIVKVL NQVGLETFVV HHEVAQAQGE VGVKFGDLVE AADNVQKLKY
260 270 280 290 300
VVKMVAHLNG KTATFMPKPL YGDNGSGMHT HVSIWKNNEN LFGGETYKGL
310 320 330 340 350
SEFALYFLGG VLRHARGLAA FTNASTNSYK RLIPGYEAPS ILTYSASNRS
360 370 380 390 400
ASVRIPYGIS KNSARFEFRF PDSSSNPYLA FGAILMAGID GIKNKMDPGE
410 420 430 440 450
AMDINLFKLT LDEIREKGIK QMPHTLRRSL EEMLADKQYL KEGQVFSEEF
460 470 480
IQAYQSLKFH SEVFPWESKP HPFEFITTYS C
Length:481
Mass (Da):54,566
Last modified:May 1, 1999 - v1
Checksum:i1F7233D870B27299
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06042.1.
PIRiB71929.
RefSeqiNP_223179.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06042; AAD06042; jhp_0461.
KEGGihpj:jhp0461.
PATRICi20605602. VBIHelPyl98156_0507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06042.1.
PIRiB71929.
RefSeqiNP_223179.1. NC_000921.1.

3D structure databases

ProteinModelPortaliQ9ZLW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85963.jhp0461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06042; AAD06042; jhp_0461.
KEGGihpj:jhp0461.
PATRICi20605602. VBIHelPyl98156_0507.

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.
OMAiKVLNQVG.
OrthoDBiEOG6B360N.

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-473-MONOMER.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiGLNA_HELPJ
AccessioniPrimary (citable) accession number: Q9ZLW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.