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Q9ZLW5 (GLNA_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:jhp_0461
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subunit structure

Oligomer of 12 subunits arranged in the form of two hexagons By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Glutamine synthetase
PRO_0000153240

Sequences

Sequence LengthMass (Da)Tools
Q9ZLW5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1F7233D870B27299

FASTA48154,566
        10         20         30         40         50         60 
MVVRTQNSES KIKEFFEFCK ENEVEFVDFR FSDIKGTWNH IAYSFGALTH DMFKEGIPFD 

        70         80         90        100        110        120 
ASSFKGWQGI EHSDMILTPD LVRYFIDPFS ADVSAVVFCD VYDVYKNQPY EKCPRSIAKK 

       130        140        150        160        170        180 
ALKHLRDLGL GDVAYFGAEN EFFIFDSIKI KDASNSQYYE VDSEEGEWNR DKSFENGVNF 

       190        200        210        220        230        240 
GHRPGKQGGY MPVPPTDTMM DIRTEIVKVL NQVGLETFVV HHEVAQAQGE VGVKFGDLVE 

       250        260        270        280        290        300 
AADNVQKLKY VVKMVAHLNG KTATFMPKPL YGDNGSGMHT HVSIWKNNEN LFGGETYKGL 

       310        320        330        340        350        360 
SEFALYFLGG VLRHARGLAA FTNASTNSYK RLIPGYEAPS ILTYSASNRS ASVRIPYGIS 

       370        380        390        400        410        420 
KNSARFEFRF PDSSSNPYLA FGAILMAGID GIKNKMDPGE AMDINLFKLT LDEIREKGIK 

       430        440        450        460        470        480 
QMPHTLRRSL EEMLADKQYL KEGQVFSEEF IQAYQSLKFH SEVFPWESKP HPFEFITTYS 


C 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD06042.1.
PIRB71929.
RefSeqNP_223179.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZLW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85963.jhp0461.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD06042; AAD06042; jhp_0461.
GeneID889208.
KEGGhpj:jhp0461.
PATRIC20605602. VBIHelPyl98156_0507.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0174.
KOK01915.
OMARAHHEVG.
OrthoDBEOG6B360N.
ProtClustDBCLSK872373.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-473-MONOMER.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_HELPJ
AccessionPrimary (citable) accession number: Q9ZLW5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families