Reviewed, UniProtKB/Swiss-Prot Q9ZLT1 (CAGA_HELPJ)

Names and origin

Protein names

Recommended name:
    Cytotoxicity-associated immunodominant antigen
Alternative name(s):
    120 kDa protein
    CAG pathogenicity island protein 26

Gene names

Name:	cagA
Synonyms:	cag26, cai
Ordered Locus Names:	jhp_0495

Organism

Helicobacter pylori J99 (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	1167 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Function

May be necessary for the transcription, folding, export, or function of the cytotoxin.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	toxin transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1167	1167	Cytotoxicity-associated immunodominant antigen		PRO_0000089278
Regions
	Compositional bias	246 – 249	4	Poly-Thr
	Compositional bias	882 – 889	8	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q9ZLT1-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: FD5E86B81CEBD0F2	FASTA	1,167	129,730
	10 20 30 40 50 60 MTNEAINQQP QTEAAFNPQQ FINNLQVAFI KVDNVVASFD PNQKPIVDKN DRDNRQAFEK 70 80 90 100 110 120 ISQLREEFAN KAIKNPTKKN QYFSSFISKS NDLIDKDNLI DTGSSIKSFQ KFGTQRYQIF 130 140 150 160 170 180 MNWVSHQNDP SKINTQKIRG FMENIIQPPI SDDKEKAEFL RSAKQAFAGI IIGNQIRSDQ 190 200 210 220 230 240 KFMGVFDESL KERQEAEKNG EPNGDPTGGD WLDIFLSFVF NKKQSSDLKE TLNQEPVPHV 250 260 270 280 290 300 QPDVATTTTD IQSLPPEARD LLDERGNFSK FTLGDMNMLD VEGVADIDPN YKFNQLLIHN 310 320 330 340 350 360 NALSSVLMGS HNGIEPEKVS LLYGNNGGPE ARHDWNATVG YKNQRGDNVA TLINVHMKNG 370 380 390 400 410 420 SGLVIAGGEK GINNPSFYLY KEDQLTGSQR ALSQEEIQNK VDFMEFLAQN NAKLDNLSKK 430 440 450 460 470 480 EKEKFQNEIE DFQKDSKAYL DALGNDHIAF VSKKDKKHLA LVAEFGNGEL SYTLKDYGKK 490 500 510 520 530 540 ADKALDREAK TTLQGSLKHD GVMFVDYSNF KYTNASKSPD KGVGATNGVS HLEAGFSKVA 550 560 570 580 590 600 VFNLPNLNNL AITSVVRQDL EDKLIAKGLS PQEANKLVKD FLSSNKELVG KALNFNKAVA 610 620 630 640 650 660 EAKNTGNYDE VKQAQKDLEK SLKKRERLEK DVAKNLESKS GNKNKMEAKS QANSQKDEIF 670 680 690 700 710 720 ALINKEANRD ARAIAYAQNL KGIKRELSDK LENINKDLKD FSKSFDEFKN GKNKDFSKAE 730 740 750 760 770 780 ETLKALKGSV KDLGINPEWI SKVENLNAAL NEFKNGKNKD FSKVTQAKSD LENSIKDVII 790 800 810 820 830 840 NQKITDKVDN LNQAVSVAKA TGDFSGVEQA LADLKNFSKE QLAQQAQKNE DFNTGKNSAL 850 860 870 880 890 900 YQSVKNGVNG TLVGNGLSKA EATTLSKNFS DIKKELNAKL GNFNNNNNNG LENSTEPIYT 910 920 930 940 950 960 QVAKKVKAKI DRLDQIASGL GDVGQAASFL LKRHDKVDDL SKVGLSANHE PIYATIDDLG 970 980 990 1000 1010 1020 GPFPLKRHDK VDDLSKVGLS REQKLTQKID NLNQAVSEAK ASHFDNLDQM IDKLKDSTKK 1030 1040 1050 1060 1070 1080 NVVNLYVESA KKVPTSLSAK LDNYATNSHT RINSNVKNGT INEKATGMLT QKNSEWLKLV 1090 1100 1110 1120 1130 1140 NDKIVAHNVG SAPLSAYDKI GFNQKNMKDY SDSFKFSTRL SNAVKDIKSG FVQFLTNIFS 1150 1160 MGSYSLMKAS VEHGVKNTNT KGGFQKS

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06073.1.
PIR	B71924.
RefSeq	NP_223213.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ZLT1. 1 interaction.
STRING	Q9ZLT1.
Genome annotation databases
GeneID	889201.
GenomeReviews	Gene locus jhp_0495 in contig AE001439_GR.
KEGG	hpj:jhp0495.
NMPDR	fig|85963.1.peg.491.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG501747.
OMA	LKRHDKV.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0495-MONOMER.
Family and domain databases
InterPro	IPR005169. CagA. IPR004355. IVSec_cagA. [Graphical view]
Pfam	PF03507. CagA. 1 hit. [Graphical view]
PRINTS	PR01553. TYPE4SSCAGA.
ProtoNet	Search...

Entry information

Entry name

CAGA_HELPJ

Accession

Primary (citable) accession number: Q9ZLT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)