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Protein

Cytotoxicity-associated immunodominant antigen

Gene

cagA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

May be necessary for the transcription, folding, export, or function of the cytotoxin.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytotoxicity-associated immunodominant antigen
Alternative name(s):
120 kDa protein
CAG pathogenicity island protein 26
Gene namesi
Name:cagA
Synonyms:cag26, cai
Ordered Locus Names:jhp_0495
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11671167Cytotoxicity-associated immunodominant antigenPRO_0000089278Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ9ZLT1. 1 interaction.
STRINGi85963.jhp0495.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 2494Poly-Thr
Compositional biasi882 – 8898Poly-Asn

Phylogenomic databases

KOiK15842.
OMAiPNYKFNQ.
OrthoDBiEOG689HMM.

Family and domain databases

InterProiIPR005169. CagA.
IPR004355. IVSec_CagA.
[Graphical view]
PfamiPF03507. CagA. 1 hit.
[Graphical view]
PRINTSiPR01553. TYPE4SSCAGA.

Sequencei

Sequence statusi: Complete.

Q9ZLT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNEAINQQP QTEAAFNPQQ FINNLQVAFI KVDNVVASFD PNQKPIVDKN
60 70 80 90 100
DRDNRQAFEK ISQLREEFAN KAIKNPTKKN QYFSSFISKS NDLIDKDNLI
110 120 130 140 150
DTGSSIKSFQ KFGTQRYQIF MNWVSHQNDP SKINTQKIRG FMENIIQPPI
160 170 180 190 200
SDDKEKAEFL RSAKQAFAGI IIGNQIRSDQ KFMGVFDESL KERQEAEKNG
210 220 230 240 250
EPNGDPTGGD WLDIFLSFVF NKKQSSDLKE TLNQEPVPHV QPDVATTTTD
260 270 280 290 300
IQSLPPEARD LLDERGNFSK FTLGDMNMLD VEGVADIDPN YKFNQLLIHN
310 320 330 340 350
NALSSVLMGS HNGIEPEKVS LLYGNNGGPE ARHDWNATVG YKNQRGDNVA
360 370 380 390 400
TLINVHMKNG SGLVIAGGEK GINNPSFYLY KEDQLTGSQR ALSQEEIQNK
410 420 430 440 450
VDFMEFLAQN NAKLDNLSKK EKEKFQNEIE DFQKDSKAYL DALGNDHIAF
460 470 480 490 500
VSKKDKKHLA LVAEFGNGEL SYTLKDYGKK ADKALDREAK TTLQGSLKHD
510 520 530 540 550
GVMFVDYSNF KYTNASKSPD KGVGATNGVS HLEAGFSKVA VFNLPNLNNL
560 570 580 590 600
AITSVVRQDL EDKLIAKGLS PQEANKLVKD FLSSNKELVG KALNFNKAVA
610 620 630 640 650
EAKNTGNYDE VKQAQKDLEK SLKKRERLEK DVAKNLESKS GNKNKMEAKS
660 670 680 690 700
QANSQKDEIF ALINKEANRD ARAIAYAQNL KGIKRELSDK LENINKDLKD
710 720 730 740 750
FSKSFDEFKN GKNKDFSKAE ETLKALKGSV KDLGINPEWI SKVENLNAAL
760 770 780 790 800
NEFKNGKNKD FSKVTQAKSD LENSIKDVII NQKITDKVDN LNQAVSVAKA
810 820 830 840 850
TGDFSGVEQA LADLKNFSKE QLAQQAQKNE DFNTGKNSAL YQSVKNGVNG
860 870 880 890 900
TLVGNGLSKA EATTLSKNFS DIKKELNAKL GNFNNNNNNG LENSTEPIYT
910 920 930 940 950
QVAKKVKAKI DRLDQIASGL GDVGQAASFL LKRHDKVDDL SKVGLSANHE
960 970 980 990 1000
PIYATIDDLG GPFPLKRHDK VDDLSKVGLS REQKLTQKID NLNQAVSEAK
1010 1020 1030 1040 1050
ASHFDNLDQM IDKLKDSTKK NVVNLYVESA KKVPTSLSAK LDNYATNSHT
1060 1070 1080 1090 1100
RINSNVKNGT INEKATGMLT QKNSEWLKLV NDKIVAHNVG SAPLSAYDKI
1110 1120 1130 1140 1150
GFNQKNMKDY SDSFKFSTRL SNAVKDIKSG FVQFLTNIFS MGSYSLMKAS
1160
VEHGVKNTNT KGGFQKS
Length:1,167
Mass (Da):129,730
Last modified:May 1, 1999 - v1
Checksum:iFD5E86B81CEBD0F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06073.1.
PIRiB71924.
RefSeqiWP_000180410.1. NC_000921.1.

Genome annotation databases

EnsemblBacteriaiAAD06073; AAD06073; jhp_0495.
KEGGihpj:jhp_0495.
PATRICi20605678. VBIHelPyl98156_0545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD06073.1.
PIRiB71924.
RefSeqiWP_000180410.1. NC_000921.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ZLT1. 1 interaction.
STRINGi85963.jhp0495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06073; AAD06073; jhp_0495.
KEGGihpj:jhp_0495.
PATRICi20605678. VBIHelPyl98156_0545.

Phylogenomic databases

KOiK15842.
OMAiPNYKFNQ.
OrthoDBiEOG689HMM.

Enzyme and pathway databases

BioCyciHPYL85963:GJB9-507-MONOMER.

Family and domain databases

InterProiIPR005169. CagA.
IPR004355. IVSec_CagA.
[Graphical view]
PfamiPF03507. CagA. 1 hit.
[Graphical view]
PRINTSiPR01553. TYPE4SSCAGA.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: J99 / ATCC 700824.

Entry informationi

Entry nameiCAGA_HELPJ
AccessioniPrimary (citable) accession number: Q9ZLT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: December 9, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.