Q9ZLS8 (RSMI_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase I
EC=2.1.1.198

Alternative name(s):
16S rRNA 2'-O-ribose C1402 methyltransferase
rRNA (cytidine-2'-O-)-methyltransferase RsmI

Gene names

Name:	rsmI
Ordered Locus Names:	jhp_0499

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA By similarity. HAMAP MF_01877
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytosine(1402) in 16S rRNA. HAMAP MF_01877
Subcellular location	Cytoplasm Potential HAMAP MF_01877.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmI family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Ribosomal RNA small subunit methyltransferase I HAMAP MF_01877		PRO_0000211942

Sequences

	Sequence		Length	Mass (Da)
	Q9ZLS8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: CBF6FFE6694FF8A4	FASTA	289	33,042
	10 20 30 40 50 60 MLYFLPTPIG NLADITLRTL EVLERCEVFL CEDTRVSKRL LHLLAKNPII SHSFPNIAAK 70 80 90 100 110 120 KREFIAFHSH NDQEFLNQIE PSFFDKEIAV MSDAGMPSLS DPGMSLVAYA LKHNLQYDVL 130 140 150 160 170 180 PGANALTTAF CASGFLEGRF FYAGFLPHKS KERRLRIIKI LNALAYLEEK TPVVFYESPH 190 200 210 220 230 240 RLLETLRDLN DLAQGMHLFA AKELTKLHQQ YYLGEISQIM TQLQKSNIQG EWVLVLLNEK 250 260 270 280 KIEPSMGLSA LLELDLPPKI KAKMEAAMTQ KNAKELYFQR LLEEKKQCD

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06077.1.
PIR	F71924.
RefSeq	NP_223217.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZLS8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZLS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	889204.
GenomeReviews	Gene locus jhp_0499 in contig AE001439_GR.
KEGG	hpj:jhp0499.
NMPDR	fig|85963.1.peg.495.
PATRIC	20605688. VBIHelPyl98156_0550.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0313.
HOGENOM	HBG529058.
OMA	TTAFCAS.
PhylomeDB	Q9ZLS8.
ProtClustDB	CLSK872376.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0499-MONOMER.
Family and domain databases
HAMAP	MF_01877. 16SrRNA_methyltr_I. [Tree]
InterPro	IPR000878. 4pyrrol_Mease. IPR014777. 4pyrrole_Mease_sub1. IPR008189. rRNA_ssu_MeTfrase_I. IPR018063. SAM_MeTrfase_RsmI_CS. [Graphical view]
Gene3D	G3DSA:3.40.1010.10. 4pyrrole_Mease_sub1. 1 hit.
KO	K07056.
PANTHER	PTHR21091:SF18. PTHR21091:SF18. 1 hit.
Pfam	PF00590. TP_methylase. 1 hit. [Graphical view]
PIRSF	PIRSF005917. MTase_YraL. 1 hit.
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit.
TIGRFAMs	TIGR00096. TIGR00096. 1 hit.
PROSITE	PS01296. RSMI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMI_HELPJ

Accession

Primary (citable) accession number: Q9ZLS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program