Q9ZLL8 (KAD_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	jhp_0561

Organism

Helicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]

Taxonomic identifier

85963 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Adenylate kinase HAMAP MF_00235		PRO_0000158779
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity
	Nucleotide binding	35 – 63	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ZLL8 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: E1CB400485FF0AE1	FASTA	191	21,409
	10 20 30 40 50 60 MKQLFLIIGA PGSGKTTDAE LIAKNNSETI AHFSTGDLLR AESAKKTERG LLIEKFTSQG 70 80 90 100 110 120 ELVPLEIVVE TILSAIKSSS KGIILIDGYP RSVEQMQALD KELNAQNEVI LKSVIEVEVS 130 140 150 160 170 180 ENTAKERVLG RSRGADDNER VFHNRMRVFL DPLVEIQNFY KAKHLHKIIN GERSIEEIVN 190 EMQKYILSFA N

References

[1]

"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori." Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Nature 397:176-180(1999) [PubMed: 9923682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J99.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001439 Genomic DNA. Translation: AAD06144.1.
PIR	D71916.
RefSeq	NP_223279.1. NC_000921.1.
3D structure databases
ProteinModelPortal	Q9ZLL8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ZLL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	889263.
GenomeReviews	Gene locus jhp_0561 in contig AE001439_GR.
KEGG	hpj:jhp0561.
NMPDR	fig|85963.1.peg.557.
PATRIC	20605822. VBIHelPyl98156_0617.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0563.
HOGENOM	HBG630208.
OMA	EMQKYIL.
ProtClustDB	PRK00279.
Enzyme and pathway databases
BioCyc	HPYL85963:JHP0561-MONOMER.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR000850. Adenylate_kin. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_HELPJ

Accession

Primary (citable) accession number: Q9ZLL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program