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Q9ZLI5 (ASPA_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate ammonia-lyase
Short name=Aspartase
EC=4.3.1.1
Gene names
Name:aspA
Ordered Locus Names:jhp_0594
OrganismHelicobacter pylori (strain J99) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate = fumarate + NH3.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

Ontologies

Keywords
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaspartate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular functionaspartate ammonia-lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Aspartate ammonia-lyase
PRO_0000161343

Regions

Region138 – 1403Substrate binding By similarity

Sites

Binding site991Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ZLI5 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B7C6200CBA19442C

FASTA46851,937
        10         20         30         40         50         60 
MRIEHDFIGQ MEISDEVYYG IQTLRASENF FITNDKLCSY PVFIKSFAQV KKAAALANAQ 

        70         80         90        100        110        120 
LGLIDEKLKI AICHACDLLV DGKYHDQFIV DMIQGGAGTS TNMNMNEVIA NLALEYMGHQ 

       130        140        150        160        170        180 
KGEYQFCHPN DHVNRSQSTN DAYPSALKIA IYERLSNLVA PMKALRDAFA QKAKEFAHVI 

       190        200        210        220        230        240 
KMGRTQLQDA VPMTLGQEFE TYALMVDRDI EQVLDARNWV RELNLGGTVI GTGINSHPDY 

       250        260        270        280        290        300 
RSLIEKKIQE VTGRPFVMAN NLIEATQSTG AYVQVSGVLK RIAVKLSKVC NDLRLLSSGP 

       310        320        330        340        350        360 
RAGLNEINLP KMQPGSSIMP GKVNPVIPEV VNQVCFAVIG NDLSVALAAE GGQLQLNVFE 

       370        380        390        400        410        420 
PVIAYKLFHS FVILGRAIET LTTKCVEGIT ANEKICHDYV FNSIGIVTAL NPHIGYEKSA 

       430        440        450        460 
MIAKEALKSD RSIYDIALEK KILTKEQLDD IFKPENMLSP HAFKKHKD

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed: 9923682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001439 Genomic DNA. Translation: AAD06167.1.
PIRH71913.
RefSeqNP_223312.1. NC_000921.1.

3D structure databases

ProteinModelPortalQ9ZLI5.
SMRQ9ZLI5. Positions 1-453.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ZLI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID890323.
GenomeReviewsGene locus jhp_0594 in contig AE001439_GR.
KEGGhpj:jhp0594.
NMPDRfig|85963.1.peg.590.
PATRIC20605897. VBIHelPyl98156_0654.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1027.
HOGENOMHBG284369.
OMAEGITANE.
ProtClustDBPRK12273.

Enzyme and pathway databases

BioCycHPYL85963:JHP0594-MONOMER.

Family and domain databases

InterProIPR004708. ApsA.
IPR003031. D_crystallin.
IPR018951. Fumarase_C_C.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR024083. L-Aspartase-like_N.
IPR022761. Lyase1_N.
[Graphical view]
Gene3DG3DSA:1.10.275.10. G3DSA:1.10.275.10. 1 hit.
KOK01744.
PfamPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00839. AspA. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASPA_HELPJ
AccessionPrimary (citable) accession number: Q9ZLI5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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