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Q9ZLI1 (FTN_HELPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin

EC=1.16.3.1
Gene names
Name:ftnA
Synonyms:pfr
Ordered Locus Names:jhp_0598
OrganismHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) [Complete proteome] [HAMAP]
Taxonomic identifier85963 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Iron-storage protein By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ferritin family. Prokaryotic subfamily.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Ferritin
PRO_0000201097

Regions

Domain1 – 145145Ferritin-like diiron

Sites

Metal binding171Iron 1 By similarity
Metal binding501Iron 1 By similarity
Metal binding501Iron 2 By similarity
Metal binding531Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding1271Iron 2 By similarity

Secondary structure

............... 167
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9ZLI1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D18B7F3F2CAD9CFC

FASTA16719,314
        10         20         30         40         50         60 
MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE YEHAKKLIIF 

        70         80         90        100        110        120 
LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES INNIVDHAIK SKDHATFNFL 

       130        140        150        160 
QWYVAEQHEE EVLFKDILDK IELIGNENHG LYLADQYVKG IAKSRKS 

« Hide

References

[1]"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori."
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D. expand/collapse author list , Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.
Nature 397:176-180(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: J99 / ATCC 700824.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001439 Genomic DNA. Translation: AAD06160.1.
PIRD71914.
RefSeqNP_223316.1. NC_000921.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3BVEX-ray1.80A/B/C/D/E/F1-167[»]
3BVFX-ray1.50A/B/C/D/E/F1-167[»]
3BVIX-ray2.00A/B/C/D/E/F1-167[»]
3BVKX-ray1.50A/B/C/D/E/F1-167[»]
3BVLX-ray1.80A/B/C/D/E/F1-167[»]
3EGMX-ray2.10A/B/C/D/E/F1-167[»]
ProteinModelPortalQ9ZLI1.
SMRQ9ZLI1. Positions 1-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-45565N.
STRING85963.jhp0598.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD06160; AAD06160; jhp_0598.
GeneID890319.
KEGGhpj:jhp0598.
PATRIC20605905. VBIHelPyl98156_0658.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1528.
KOK02217.
OMACEDKGFE.
OrthoDBEOG6G4W12.
ProtClustDBCLSK872406.

Enzyme and pathway databases

BioCycHPYL85963:GJB9-609-MONOMER.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9ZLI1.

Entry information

Entry nameFTN_HELPJ
AccessionPrimary (citable) accession number: Q9ZLI1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 13, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references