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Q9ZLI1

- FTN_HELPJ

UniProt

Q9ZLI1 - FTN_HELPJ

Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Iron-storage protein.By similarity

    Catalytic activityi

    4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
    Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHPYL85963:GJB9-609-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterial non-heme ferritin (EC:1.16.3.2)
    Gene namesi
    Name:ftnA
    Synonyms:pfr
    Ordered Locus Names:jhp_0598
    OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
    Taxonomic identifieri85963 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000804: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Bacterial non-heme ferritinPRO_0000201097Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

    Protein-protein interaction databases

    DIPiDIP-45565N.
    STRINGi85963.jhp0598.

    Structurei

    Secondary structure

    1
    167
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 3229
    Turni33 – 353
    Helixi37 – 6327
    Helixi83 – 11028
    Helixi114 – 1196
    Helixi121 – 14424
    Beta strandi146 – 1494
    Helixi150 – 16516

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BVEX-ray1.80A/B/C/D/E/F1-167[»]
    3BVFX-ray1.50A/B/C/D/E/F1-167[»]
    3BVIX-ray2.00A/B/C/D/E/F1-167[»]
    3BVKX-ray1.50A/B/C/D/E/F1-167[»]
    3BVLX-ray1.80A/B/C/D/E/F1-167[»]
    3EGMX-ray2.10A/B/C/D/E/F1-167[»]
    ProteinModelPortaliQ9ZLI1.
    SMRiQ9ZLI1. Positions 1-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ZLI1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    KOiK02217.
    OMAiCEDKGFE.
    OrthoDBiEOG6G4W12.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ZLI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSKDIIKLL NEQVNKEMNS SNLYMSMSSW CYTHSLDGAG LFLFDHAAEE    50
    YEHAKKLIIF LNENNVPVQL TSISAPEHKF EGLTQIFQKA YEHEQHISES 100
    INNIVDHAIK SKDHATFNFL QWYVAEQHEE EVLFKDILDK IELIGNENHG 150
    LYLADQYVKG IAKSRKS 167
    Length:167
    Mass (Da):19,314
    Last modified:May 1, 1999 - v1
    Checksum:iD18B7F3F2CAD9CFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06160.1.
    PIRiD71914.
    RefSeqiNP_223316.1. NC_000921.1.

    Genome annotation databases

    EnsemblBacteriaiAAD06160; AAD06160; jhp_0598.
    GeneIDi890319.
    KEGGihpj:jhp0598.
    PATRICi20605905. VBIHelPyl98156_0658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001439 Genomic DNA. Translation: AAD06160.1 .
    PIRi D71914.
    RefSeqi NP_223316.1. NC_000921.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BVE X-ray 1.80 A/B/C/D/E/F 1-167 [» ]
    3BVF X-ray 1.50 A/B/C/D/E/F 1-167 [» ]
    3BVI X-ray 2.00 A/B/C/D/E/F 1-167 [» ]
    3BVK X-ray 1.50 A/B/C/D/E/F 1-167 [» ]
    3BVL X-ray 1.80 A/B/C/D/E/F 1-167 [» ]
    3EGM X-ray 2.10 A/B/C/D/E/F 1-167 [» ]
    ProteinModelPortali Q9ZLI1.
    SMRi Q9ZLI1. Positions 1-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-45565N.
    STRINGi 85963.jhp0598.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD06160 ; AAD06160 ; jhp_0598 .
    GeneIDi 890319.
    KEGGi hpj:jhp0598.
    PATRICi 20605905. VBIHelPyl98156_0658.

    Phylogenomic databases

    eggNOGi COG1528.
    KOi K02217.
    OMAi CEDKGFE.
    OrthoDBi EOG6G4W12.

    Enzyme and pathway databases

    BioCyci HPYL85963:GJB9-609-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9ZLI1.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: J99 / ATCC 700824.

    Entry informationi

    Entry nameiFTN_HELPJ
    AccessioniPrimary (citable) accession number: Q9ZLI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3